Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 11 de 11
Filter
Add more filters










Publication year range
1.
Lupus ; 17(6): 596-604, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18539716

ABSTRACT

To evaluate disease characteristics of childhood onset SLE in Latin America and to compare this information with an adult population in the same cohort of GLADEL. A protocol was designed as a multicenter, multinational, inception cohort of lupus patients to evaluate demographic, clinical, laboratory and serological variables, as well as classification criteria, disease activity, organ damage and mortality. Descriptive statistics, chi square, Fisher's exact test, Student's t test and multiple logistic regression were used to compare childhood and adult onset SLE. 230 patients were <18 years and 884 were adult SLE patients. Malar rash, fever, oral ulcers, thrombocytopenia and hemolytic anemia and some neurologic manifestations were more prevalent in children (p<0.05). On the other hand, myalgias, Sjögren's syndrome and cranial nerve involvement were more frequently seen in adults (p<0.05). Afro-Latin-American children had a higher prevalence of fever, thrombocytopenia and hemolytic anemia. White and mestizo children had a higher prevalence of malar rash. Mestizo children had a higher prevalence of cerebrovascular disease and cranial nerve involvement. Children met SLE ACR criteria earlier with higher mean values than adults (p: 0.001). They also had higher disease activity scores (p: 0.01), whereas adults had greater disease damage (p: 0.02). In Latin America, childhood onset SLE seems to be a more severe disease than adults. Some differences can be detected among ethnic groups.


Subject(s)
Lupus Erythematosus, Systemic , Adolescent , Adult , Age of Onset , Child , Female , Humans , Latin America/epidemiology , Lupus Erythematosus, Systemic/epidemiology , Lupus Erythematosus, Systemic/physiopathology , Male
6.
Medicina (B Aires) ; 63(3): 221-3, 2003.
Article in Spanish | MEDLINE | ID: mdl-12876906

ABSTRACT

A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.


Subject(s)
Brain Neoplasms/pathology , Lupus Erythematosus, Systemic/pathology , Lymphoma, Large B-Cell, Diffuse/pathology , Adult , Fatal Outcome , Female , Humans , Immunosuppressive Agents/therapeutic use , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/drug therapy , Magnetic Resonance Imaging
7.
Medicina (B.Aires) ; 63(3): 221-223, 2003. ilus
Article in Spanish | LILACS | ID: lil-343170

ABSTRACT

Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico.


Subject(s)
Humans , Male , Female , Adult , Brain Neoplasms , Lupus Erythematosus, Systemic , Lymphoma, Large B-Cell, Diffuse , Fatal Outcome , Immunosuppressive Agents , Lupus Erythematosus, Systemic , Magnetic Resonance Imaging
8.
Medicina [B.Aires] ; 63(3): 221-223, 2003. ilus
Article in Spanish | BINACIS | ID: bin-5772

ABSTRACT

Se presenta una paciente de 36 años con diagnóstico de lupus eritematoso sistémico tratada con prednisona y ciclofosfamida que se internó por cefalea, hemiparesia y hemianestesia braquiocrural derecha de dos semanas de evolución. Se realizó una tomografía computada y una resonancia magnética nuclear de cerebro que mostraron una lesión nodular frontal izquierda. Se efectuó una biopsia a cielo abierto de la lesión cerebral cuyo diagnóstico histopatológico fue linfoma B de celulas grandes, difuso. Se inició radioterapia, no completó el tratamiento por complicaciones y falleció. Son muy pocos los casos publicados de linfoma primario del sistema nervioso central asociado a lupus eritematoso sistémico.(AU)


Subject(s)
Humans , Male , Female , Adult , Brain Neoplasms/pathology , Lymphoma, Large B-Cell, Diffuse/pathology , Lupus Erythematosus, Systemic/pathology , Fatal Outcome , Immunosuppressive Agents/therapeutic use , Magnetic Resonance Imaging , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/drug therapy
9.
Medicina [B Aires] ; 63(3): 221-3, 2003.
Article in Spanish | BINACIS | ID: bin-38948

ABSTRACT

A 36 year-old woman with systemic lupus erythematosus was admitted to our hospital with headache, brachiocrural hemiparesis and hemianesthesia. She had been treated with prednisone and cyclophosphamide. CT scan and MRI revealed a 15 mm nodular mass enhanced with gadolinium in left frontal convexity. CNS biopsy was performed and a diffuse large B-cell lymphoma was diagnosed. She was treated with radiation therapy without response and died. There are few reports of erythematosus systemic lupus associated with primary central nervous system lymphoma.

SELECTION OF CITATIONS
SEARCH DETAIL
...