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1.
Gene ; 568(2): 190-5, 2015 Sep 01.
Article in English | MEDLINE | ID: mdl-26024590

ABSTRACT

Animals recognize the availability of nutrients and regulate the intake and storage of these nutrients accordingly. However, the molecular mechanisms underlying nutrient sensing and subsequent changes in behavior and metabolism are not fully understood. Mlx interactor (Mio), the Drosophila homolog of carbohydrate response element binding protein (ChREBP), functions as a transcription factor in the fat body of the fly to control triglyceride storage as well as feeding, suggesting that Mio may act in a nutrient-sensing pathway to coordinate food consumption and metabolism. Here, we show that Mio functions in neurons in Drosophila to regulate feeding and nutrient storage. Pan-neuronal disruption of Mio function leads to increased triglyceride and glycogen storage, and this phenotype is not due to increased food consumption. Interestingly, targeted disruption of Mio specifically in the insulin-producing cells (IPCs) has little effect on nutrient storage, but increases food consumption suggesting that Mio acts in these neurons to control feeding behavior. Since Mio is a transcription factor, one possible way Mio may act in the IPCs to control feeding is through regulating the expression of Drosophila insulin-like peptides (dilps) or drosulfakinin (dsk), neuropeptides produced in the IPCs. Consistent with this hypothesis, IPC-specific knockdown of Mio leads to an increase in dilp3 expression, while not affecting dilp2, 5 or dsk levels. Together, this study indicates a new function for Mio in the Drosophila brain and specifically in the IPCs, controlling neuropeptide gene expression, feeding and metabolism in accordance with nutrient availability.


Subject(s)
Brain/metabolism , Drosophila Proteins/physiology , Drosophila melanogaster/metabolism , Nuclear Proteins/physiology , Animals , Brain/cytology , Cell Cycle Proteins , Energy Metabolism , Fat Body/metabolism , Feeding Behavior , Female , Glycogen/metabolism , Insulin/biosynthesis , Lipid Metabolism , Neurons/physiology
2.
Case Rep Vasc Med ; 2013: 124832, 2013.
Article in English | MEDLINE | ID: mdl-23365781

ABSTRACT

Anastomotic pseudoaneurysms are common entities following vascular bypass procedures and, if left untreated, serious complications such as thromboses, infection, and rupture can frequently occur. Therefore, attempts to employ various methods of repair have been utilized in treating anastomotic pseudoaneurysms to maximize operational success and future risk reduction. Herein, the authors report two cases of anastomotic pseudoaneurysms which were repaired percutaneously utilizing a combination of strategies such as careful preoperational image planning, multiple commercially available devices, and secondary embolization techniques.

3.
Expert Rev Med Devices ; 7(1): 11-9, 2010 Jan.
Article in English | MEDLINE | ID: mdl-20021237

ABSTRACT

Permanent or temporary implantation of inferior vena cava filters for protection against pulmonary embolism is well established. There have been numerous devices developed for this purpose, each of which has proprietary design considerations that affect performance and potentially impose limitations with regard to positioning, efficacy and risk profile. This article describes a recently developed, unique inferior vena cava filter design that employs a separated filtration component and a novel double-ring anchoring system that allows intraprocedural capture and repositioning for optimized placement. In addition, early experience suggests easy removal when desired, a high rate of filtration success and excellent caval patency.


Subject(s)
Pulmonary Embolism/prevention & control , Vena Cava Filters , Animals , Filtration/instrumentation , Humans
4.
Clin Electroencephalogr ; 34(2): 75-83, 2003 Apr.
Article in English | MEDLINE | ID: mdl-12784905

ABSTRACT

In two published pilot studies and a controlled replication using screened normals, chronic marihuana (THC) use was associated with a unique topographic quantitative EEG profile, consisting of significant elevations of Absolute and Relative Power and Coherence of alpha activity over the bilateral frontal cortex as well as a significant decrease in alpha frequency. This report attempts to establish the causal influence of THC in the above findings by the transient production of this exact quantitative EEG profile in subjects who did not display it at the beginning. Using paced smoking of marihuana with high and low dose THC content and placebo marihuana in a counterbalanced design under double blind conditions, all four of the topographic features of chronic THC exposure were produced as transient effects by THC but not by placebo.


Subject(s)
Dronabinol/pharmacology , Electroencephalography/drug effects , Marijuana Smoking , Adult , Brain/drug effects , Dronabinol/administration & dosage , Female , Humans , Male
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