ABSTRACT
Electron microscopy of the pineal gland in gamma-irradiated rats treated with epithalon revealed ultrastructural signs attesting to enhancement of its functional activity.
Subject(s)
Oligopeptides/pharmacology , Pineal Gland/drug effects , Pineal Gland/radiation effects , Animals , Antioxidants/pharmacology , Gamma Rays , Male , Pineal Gland/pathology , Pineal Gland/ultrastructure , Rats , Rats, WistarABSTRACT
The paper reviews methods for studying functional morphology of endocrine cells histochemistry and immunohistochemistry, radioautography and methods of ultrastructural verification of secretory granules. Methodological approach is illustrated by the authors' results on the influence of ionizing radiation and tumor growth on the cells of the diffuse endocrine system.
Subject(s)
APUD Cells/ultrastructure , APUD Cells/metabolism , APUD Cells/radiation effects , Animals , Autoradiography , Cytoplasmic Granules/ultrastructure , Histocytochemistry , ImmunohistochemistryABSTRACT
Electron microscopy has revealed endocrine secretory granules in the endothelial cells of the rat liver, spleen and bone marrow capillaries. The granules were responsible for serotonin, melatonin, catecholamines and insulin synthesis. Local mechanisms of hormonal control of hemostasis are discussed.
