ABSTRACT
The main purpose of the existing experiment was to assess the allelic and genotypic polymorphisms of the Growth hormone (GH) gene and its correlation with growth indices, efficiency of consumed feed, some body indices and carcass traits of the Egyptian Awassi sheep. Forty Egyptian Awassi male lambs were selected for their growing indices (post-weaning daily gain, marketing weight, and weaning weight), feed efficiency (consumed feed and of consumed feed), body conformational indicators (skeletal muscle index, relative body index, body mass index, and body index), and carcass features (dressing %, hot carcass weight, fore-legs %, neck %, loin %, ribs %, abdominal fat %, Tail % and hind-legs %). The polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) tool was applied to detect the genotypic and allelic GH gene polymorphisms properties. The PCR-RFLP analysis identified three main genotypes (AA, AB and BB) and two main alleles (A and B). The GH genotype (AA or AB) exhibited moderate significant influence (P < 0.05) on marketing weight, Loin% and Tail%. Also, genotype (AB or BB) of expressed GH gene significantly (P < 0.01) influence on consumed feed, post-weaning daily gain, neck% and body mass index, whereas, it had no influence on the phenotypic values of the other characteristics investigated. The presence of the A allele in the genotype was markedly associated (P < 0.01) with consumed feed, body mass index and post-weaning daily growth; conversely, the presence of the B allele in the genotype was significantly related (P < 0.05) with marketing weight, loin %, and tail %. While, GH gene expression was revealed to be highly significant (P < 0.01) in relation to post-weaning daily growth, feed intake, and neck %. According to the findings, determining the associations between GH gene variation and growth, efficiency of consumed feed, body measurements, and carcass features of Egyptian Awassi sheep and applying marker assisted selection with the GH gene to improve these traits is warranted and will be of significant economic value to sheep production.
ABSTRACT
A 13-year-old boy with neurofibromatosis type 1 presented to the emergency department twice in a fortnight with moderate intermittent abdominal pain, radiating to the back and associated with nausea and vomiting. He examined as a well child with a soft abdomen and minimal tenderness. A history of constipation was identified but he failed to respond to a trial of laxatives. Subsequent ultrasound abdomen demonstrated a large mass surrounding the porta hepatis. MRI further characterised a focal, non-aggressive lesion extending from his liver, encapsulating his pancreas, portal vessels and laterally displacing his spleen and left kidney. Biopsy performed at a specialist cancer treatment hospital of our reference later confirmed this to be a benign neurofibroma of a size not previously reported in the literature. He will be managed conservatively with surveillance imaging and the potential for chemotherapy should the lesion continue to grow.
Subject(s)
Abdominal Neoplasms/pathology , Abdominal Pain/diagnostic imaging , Incidental Findings , Neurofibroma/pathology , Neurofibromatosis 1/complications , Abdominal Neoplasms/diagnostic imaging , Abdominal Neoplasms/etiology , Abdominal Neoplasms/therapy , Adolescent , Biopsy , Conservative Treatment , Humans , Magnetic Resonance Imaging , Male , Neurofibroma/diagnostic imaging , Neurofibroma/etiology , Neurofibroma/therapy , UltrasonographyABSTRACT
A 17-month-old girl presented with an upper respiratory tract infections, and was found to have a haemoglobin of 3.3 g/dl. Although noticeably pale, she was largely asymptomatic. Her iron deficiency anaemia was found to be the result of poor diet. With oral iron supplements and improved diet, her haemoglobin increased rapidly, and she is now doing very well.
Subject(s)
Anemia, Iron-Deficiency/etiology , Diet/adverse effects , Infant Nutrition Disorders/complications , Anemia, Iron-Deficiency/diet therapy , Anemia, Iron-Deficiency/drug therapy , Dietary Supplements , Female , Hemoglobins/metabolism , Humans , Infant , Infant Nutrition Disorders/diet therapy , Infant Nutrition Disorders/drug therapy , Iron, Dietary/therapeutic useABSTRACT
We report the unusual case of tear production with painless micturition, only once described in the medical literature in 1932. We report on a 3-year-old girl with painless "watering of her eyes every time she passed urine" present since birth and occasionally associated with a vacant look and dropping of her jaw. With only 1 previously described case in the literature but clear evidence from online fora, we describe how this phenomenon may be more common than previously thought.
