ABSTRACT
Various stages of hypokinesia are marked by specific changes in the level and activity of endogenous metalloproteins with anti- (MAA) and prooxidant action (MPA). In particular, the level of MPA [cytochromes b5 and b558 (III + IV) and suprol] decreases in all stages (except for the level of cytochrome b5 exceeding that in the free control on the 15th and 30th day of hypokinesia). The superoxide production activity of suprol always exceeds that in the control, while the activity of cytochrome b558 (III) exceeds that in the control only on the 30th day of experiment. The level and activity of MAA [ceruloplasmin, transferrin (TF), superoxide dismutase (SOD), and catalase] decrease with the duration of hypokinesia (except for 15th day, when the level of TF and the activity of SOD exceed the values in the free control group). The administration of GABA and pyrrolidone decreases the extent of oxidative stress, which is manifested by leveling of the MAA and MPA content and activity.
Subject(s)
Antioxidants/metabolism , Hypokinesia/metabolism , Metalloproteins/metabolism , Pyrrolidinones/pharmacology , Reactive Oxygen Species/metabolism , gamma-Aminobutyric Acid/pharmacology , Animals , Male , Oxidative Stress , RatsABSTRACT
GABA and its cyclic derivatives, gamma-butyrolactone and pyrrolidone-2, have been ascertained to abolish and prevent the cerebral vasoconstrictor effects of malonic dialdehyde. In this respect, gamma-butyrolactone excels pyrrolidone-2 and GABA, the effects of GABA being most slight. It may be suggested that the neuroactive amino acids exhibit antioxidative effects.
Subject(s)
4-Butyrolactone/pharmacology , Cerebrovascular Circulation/drug effects , Malondialdehyde/antagonists & inhibitors , Pyrrolidinones/pharmacology , Vasoconstriction/drug effects , gamma-Aminobutyric Acid/pharmacology , Animals , Antioxidants/pharmacology , Cats , Drug Interactions , Malondialdehyde/pharmacologyABSTRACT
Malonic dialdehyde has a pronounced central vasoconstrictor effect, though when given in large doses, it causes a profound decrease in systemic blood pressure, however its vasoconstrictor effects are not directly related to fluctuations in systemic blood pressure. The universal antioxidant alpha-tocopherol acetate abolishes and prevents the central vasoconstrictor effects of malonic dialdehyde.
