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Nanomedicine (Lond) ; 19(8): 689-708, 2024 04.
Article in English | MEDLINE | ID: mdl-38348681

ABSTRACT

Background: The effectiveness of a drug is dependent on its accumulation at the site of therapeutic action, as well as its time in circulation. The aim of the research was the creation of stable albumin/tannin (punicalagin, punicalin) particles, which might serve for the delivery of medicines. Methods: Numerous chromatographic and analytical methods, docking analyses and in vivo testing were applied and used. Results: Stable tannin-albumin/medicine particles with a diameter of ∼100 nm were obtained. The results of in vivo experiments proved that tannin-albumin particles are more stable than albumin particles. Conclusion: Based on the experiments and docking analyses, these stable particles can carry an extended number of medicines, with diverse chemical structures.


Subject(s)
Plant Extracts , Tannins , Plant Extracts/chemistry , Albumins , Phagocytosis , Antioxidants , Drug Carriers
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