ABSTRACT
The study was carried out to evaluate erythrocyte sedimentation rate, glucose level, rheumatoid factor and C-reactive protein in blood of patients with periodic peritonitis at the stage of remission. Also, effect of colchicine on activity of lactase was analyzed. It is demonstrated that frequency of increase of levels of erythrocyte sedimentation rate and C-reactive protein during period of remission differed depending on gender while at the same time indicators of rheumatoid factor were within limits of normality in all patients. Despite research literature data establishing effect of colchicine on lactose assimilability, no significant inhibition of lactose activity was established in examined volunteers.
Subject(s)
C-Reactive Protein/metabolism , Colchicine/therapeutic use , Familial Mediterranean Fever/blood , Familial Mediterranean Fever/drug therapy , Gout Suppressants/therapeutic use , Rheumatoid Factor/blood , Adolescent , Adult , Blood Glucose/metabolism , Blood Sedimentation/drug effects , Familial Mediterranean Fever/physiopathology , Female , Humans , Intestinal Absorption/drug effects , Lactase/metabolism , Lactose/metabolism , Male , Middle Aged , Remission InductionABSTRACT
Verhulst's logistic differential equation, popular in mathematical ecology, is used in modeling of population growth, neural networks, statistics, reaction models, Fermi distribution, modeling of tumor growth, etc. We used this function to characterize growth of commensal Escherichia coli isolates from gut microflora in Crohn's disease patients. The results of our investigations show differences in growth parameters of commensal E. coli, isolated from the gut microflora in Crohn's disease patients and healthy volunteers; it is most likely explained by the influence of chronic inflammatory processes on growth and reproduction of these bacteria. It has been established that the used mathematical model well characterizes growth of patients' gut E. coli isolates, and it can be important for the expedient probiotics' application during the disease.
