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5.
Article in Russian | MEDLINE | ID: mdl-1007746

ABSTRACT

A single inculation of ADP-toxoid with diminished antigen content (5 Lf of diphtheria and 5 BU of tetanus components) for diphtheria and tetanus revaccination of children aged from 1 to 11 years with allergic reactivity provided a marked immunological efficacy with an insignificant reactogenicity. The revaccinating effect was also marked in case of a prolonged lapse of time--up to 10 years (observations period) from the last vaccination. Children with allergic reactivity with contraindications to the administration of APDT vaccine and APDT vaccine and ADT-toxoid of conventional composition can be effectively revaccinated with ADT-toxoid with decreased antigen content on condition of careful clinical observation.


Subject(s)
Bacterial Vaccines , Diphtheria Toxoid , Diphtheria/prevention & control , Immunization, Secondary , Tetanus Toxoid , Tetanus/prevention & control , Child , Child, Preschool , Humans , Hypersensitivity/prevention & control , Infant
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