ABSTRACT
Background: Gastroparesis is a serious condition that can be caused by diabetes, surgery or infection, or can be idiopathic. When there is no mechanical obstruction, gastroparesis is characterized by delayed stomach emptying. Itopride, a prokinetic drug, inhibits acetylcholinesterase activity in addition to antagonizing dopamine D2 receptors. Methods: This prospective, multicentre study is based on real-world data from 988 patients with a diagnosis of diabetic gastroparesis for index (PAGI-SYM2) evaluation at baseline and week 4 of treatment for upper gastrointestinal disorder symptoms. Results: Upper gastrointestinal symptom severity scores improved significantly after 4 weeks of treatment (p<0.001), with significant improvement across all categories of gastroparesis (very mild (37-58.6%), mild degree (24.6-31.6%), moderate (29.3-7.3%) and severe (8.8-2.6%). Conclusion: Itopride SR (Nogerd SR) in a 150 mg once-daily dose showed promising results in reducing the severity of upper gastrointestinal disorder symptoms associated with diabetic gastroparesis. Both statistical and clinical effectiveness were observed. Moreover, the treatment demonstrated a favourable tolerability profile, with a low incidence of adverse effects.
ABSTRACT
Digital technologies (DTs) are proven helpful in the Architecture, Engineering and Construction (AEC) industry due to their varied benefits to project stakeholders, such as enhanced visualization, better data sharing, reduction in building waste, increased productivity, sustainable performance and safety improvement. Therefore, researchers have conducted various studies on DTs in the AEC industry over the year; however, this study explores the state-of-the-art research on DTs in the AEC industry by means of a bibliometric-qualitative review method. This research would uncover new knowledge gaps and practical needs in the domain of DTs in the AEC industry. In addition, bibliometric analysis was carried out by utilizing academic publications from Scopus (i.e., 11,047 publications for the AEC industry, 1956 for DTs and 1778 for DTs in the AEC industry). Furthermore, a qualitative review was further conducted on 200 screened selected research publications in the domain of DTs. This study brings attention to the body of knowledge by envisioning trends and patterns by defining key research interests, journals, countries, new advancements, challenges, negative attitudes and future directions towards DTs in the AEC industry. However, this study is the first in its vital importance and uniqueness by providing a broad updated review of DTs in the AEC literature. Furthermore, this research laid a foundation for future researchers, policy makers and practitioners to explore the limitations in future research.
