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Planta Med ; 88(14): 1293-1298, 2022 Nov.
Article in English | MEDLINE | ID: mdl-34963184

ABSTRACT

Two new cytochalasans with a rare 6/6/5/5/7 pentacyclic ring system, named chaetoconvosins C-D (1: -2: ), together with two known congeners (3: -4: ), were isolated from the fermentation of an endophytic fungus, Chaetomium sp. SG-01, harbored in the fibrous roots of Schisandra glaucescens Diels. Their structures including the absolute configuration were elucidated by extensive spectroscopic (HRESIMS, NMR, and ECD) and X-ray crystallographic analyses. The TRAIL-resistance-overcoming activity of 1: -4: in a TRAIL-resistant HT29 colorectal cancer cell line was evaluated, which revealed that co-treatment of 1: -4: at 50 µM with TRAIL (150 ng/mL) reduced the HT29 cell viability by 19.0%, 24.1%, 17.9%, and 15.5%, respectively, compared to treatment with 1: -4: alone.


Subject(s)
Alkaloids , Chaetomium , Chaetomium/chemistry , Chaetomium/metabolism , Crystallography, X-Ray , Magnetic Resonance Spectroscopy , Cytochalasins/pharmacology , Cytochalasins/chemistry , Molecular Structure
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