[Synthesis and inhibition on beta-lactamase of 4-(3-amido-4-substituted phenyl-2-oxo-azetidinonyl-1)methyl-cyclohexane carboxylic acids and -benzoic acids].

Eleven title compounds have been synthesized from trans-4-amino-methyl-cyclohexylic acid and 4-aminomethyl-benzoic acid, and were identified via elemental analysis, IR, 1HMNR and MS. Their beta-lactamase inhibition activity was determined and contrasted with penicillanic acid S-dioxide. The results of the preliminary test show that all the products have beta-lactamase inhibition activity to some extent.