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OBJECTIVE: To discuss the relationship between body mass index and postural tachycardia syndrome in children and adolescents. METHODS: The clinical data of 127 children and adolescents were retrospectively analyzed,who were diagnosed with postural tachycardia syndrome(POTS)in the Department of Pediatric Cardiovasology,Children's Medical Center,the Second Xiangya Hospital,Central South University,from August 2009 to June 2018,which included63 males and 64 females and their ages were from 4 to 17 years old(mean age 11.31±2.53)(POTS group). A total of 107 healthy children and adolescents including 64 males and 63 females were included as the control group,who had a health examination in the health care clinic in the hospital during the same period(aged 7 to 17,with a mean age of11.60±3.27). Body length and body mass were measured and body mass index(BMI)calculated. Statistical analysis was conducted with SPSS 22.0 software. RESULTS:(1)Duration and frequency of syncope:the duration of syncope was(8.13±13.76)months in POTS group and the frequency of syncope was(1.45±4.43)times.(2)BMI intergroup comparison:comparing POTS group with control group,there was no difference in age,length or body mass(P>0.05),and BMI was significantly lower[(17.32 ± 2.65)kg/m~2 vs.(18.17 ± 2.42)kg/m~2,t=2.655,P<0.01]in POTS group.(3)BMI classification:low body mass was higher in POTS group(69.29%,88/127)than in control group(56.69%,72/127);normal body mass was lower in POTS group(29.13%,37/127)than in control group(41.73%,53/127）,χ~2=4.444,P<0.05. CONCLUSION: BMI of POTS group decreases significantly in children and adolescents,and it is lower in girls than in boys.
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Object To compare images of the vessel wall between symptomatic and asymptomatic atherosclerotic plaques of the middle cerebral artery (MCA) using high resolution magnetic resonance imaging (HR MRI).Methods HR MRI data were acquired in 36 patients with MCA atherosclerotic stenosis (≥50％) confirmed by MRA, CTA, of whom, 25 symptomatic patients and 11 asymptomatic ones were enrolled into a symptomatic group and an asymptomatic group respectively. The wall thickness and cross-sectional area of stenotic segments were measured and compared between the two groups. The data were analyzed by SPSS 17.0 statistical software.Results The cross-sectional area in the symptomatic group was (3.04±1.03)mm2,while the asymptomatic group was (3.28±0.96)mm2, and the difference between the two groups was not statistically significant (P>0.05). The symptomatic group had a larger wall thickness ((2.32±0.61)mm) when compared with the asymptomatic group ((2.10±0.77)mm), and higher prevalence of plaque enhancement after contrast injection (83.3％).Conclusion Different vessel wall properties on HR MRI are observed between symptomatic and asymptomatic MCA stenosis. Symptomatic MCA stenosis has a larger wall thickness and higher prevalence of plaque enhancement after contrast injection when compared with the asymptomatic.
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Professional assessment in Chinese Higher Education has made great progress in three stages: the sporadic practice, trial and promotion. The authors present several comments on the characteristics and the professional assessment standards of clinical pharmacy in China, and focus on the scientific system of professional assessment.
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The etiology of recurrent miscarriage (RM) is extremely heterogeneous, including genetic, immunologic, anatomic, endocrinological, and infectious anomalies. About 50% of RM is unexplained or poorly understood, which is called idiopathic recurrent miscarriage (IRM). The primary aim of this study was to identify the genetic loci that might be susceptible to IRM. Forty-four Han Chinese patients with IRM during the first trimester of their pregnancies and 44 healthy sex- and ethnic-matched controls were enrolled in this study. A case-control and genome-wide study was performed and 430 polymorphic microsatellite markers were analyzed. Three loci, 6q27 (D6S446, P = .028), 9q33.1 (D9S1776, P = .037), and Xp22.11 (DXS1226, P = .008), significantly associated with IRM were found. This work identified 3 genetic regions that might harbor genes predisposed to IRM and provided new insights for future genetic and etiological study of IRM. Further study is required to confirm it.
