ABSTRACT
Objective To observe the effect of Shenqi Fuzheng injection combined with chemotherapy on reducing the side effects of malignant tumor chemotherapy. Methods Eighty cancer patients in Traditional Chinese Medicine Hospital of PLA General Hospital from January 2015 to March 2017 were randomly divided into treatment group and control group by using random number table method, each group contained 40 cases. The patients in the treatment group were given Shenqi Fuzheng injection combined with chemotherapy, while the control group used chemotherapy only. Results The incidence of WBC and Plt reduction in the treatment group [35.0 % (14/40), 32.5 % (13/40)] was lower than those in the control group [70.0 % (28/40), 57.5 % (23/40)], and the differences were statistically significant (χ 2= 9.825, P = 0.002;χ2=5.051, P=0.025). The incidence rates of digestive tract reaction and oral ulcers[52.5 %(21/40), 32.5 % (13/40)]were lower than those in the control group[75.0 %(30/40), 60.0 %(24/40)], and the differences were statistically significant (χ2= 4.381, P = 0.036; χ2= 6.084, P = 0.014). The quality of life in the treatment group was significantly improved compared with the control group [(51.4 ±5.1) points vs. (48.3±5.5) points], and the difference was statistically significant(t =2.595,P =0.011). Conclusions Shenqi Fuzheng injection combined with chemotherapy can reduce chemotherapy-induced side effects and improve the life quality of the patients.The injection can be used as the adjuvant therapy for chemotherapy in clinic application.
ABSTRACT
Objective:To evaluate the nutritional status before and after chemotherapy in patients with colon cancer by measuring energy metabolism and body composition.Methods:Fifty-one patients with colon cancer were included and were investigated using self-control method (before and after chemotherapy).Resting energy expenditure (REE) was determined by bed metabolic instrument,and body composition was measured by body composition analyzer.Results:For all patients,the REE on the 2nd day after chemotherapy was decreased significantly compared with that before chemotherapy (P ＜ 0.05).After chemotherapy,body fat percentage and body moisture percentage were increased significantly (P ＜ 0.05),and lean body mass percentage was decreased significantly (P ＜ 0.05).Conclusion:After chemotherapy,the REE and lean body mass percentage of the patients with colon cancer were decreased,and body fat percentage and body moisture percentage were increased.
ABSTRACT
Objective To study the relationships among health-related quality of life(HRQL), social support, excessive daytime sleepiness (EDS) and PSG parameters in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods Eighty-five patients were recruited who were diagnosed as OSAHS by overnight po]ysomnography from August 2007 through November 2007 in West China Hospital.The Calgary sleep apnea quality of life index (SAQLI) was used for HRQL, social support rating scale (SSRS) was used for social support,and Epworth sleepiness scale(ESS) was used for EDS.The Pearson linear correlation and stepwise multiple regression analysis were used to analyze the correlation among SAQLI, SSRS, ESS, and PSG.Results The SAQLI was correlated with SSRS score (r = 0.402, P < 0.01) ; ESS score (r =-0.505 ,P <0.01) ; apnea-hypopnea index (AHI) (r =-0.269,P <0.05) and lowest artery oxygen saturation (ISaO2) (r = 0.226, P < 0.05).Stepwise muhiple regression analysis determined two variables,the SSRS and ESS score,as independent factors for predicting the total score of SAQLI which accounted for 37.3% of the total variance in the total score on SAQLI (R2 = 0.373, P < 0.001).Conclusions The HRQL of patients with OSAHS was correlated with the SSRS score, ESS score and PSG parameters.The former two were the more important factors to affect the HRQL of patients with OSAHS.
