ABSTRACT
Objetivo: Analizar la bibliografía actual respecto a losefectos de la hidroterapia sobre el dolor en personas condiagnóstico de osteoartritis o fibromialgia.Metodología: Se realizó la búsqueda de la informaciónpara la revisión bibliográfica utilizando las siguientes basesde datos: PubMed, Science Direct, Scopus, Google Scho-lar, Scielo y Clinicalkey, comprendidos entre el año 2010y 2021, aunque los artículos elegidos van del 2011 enadelante. Teniendo en cuenta los criterios de inclusióny exclusión se escogieron 20 artículos para la revisión,seleccionando 11 para fibromialgia y 9 para osteoartritis.Resultados: La estructura de las intervenciones fue-ron similares con una duración de 45 a 60 minutos. Secomenzaba con movilidad articular o estiramientos, luegofortalecimiento general o ejercicio aeróbico, y se finali-zaba con estiramientos. En los artículos de fibromialgiase encontró una mejora significativa sobre el dolor en el90,9 % de los estudios y en un 88,8 % para los estudiosde osteoartritis.Conclusiones: La hidroterapia tiene beneficios a cortoplazo sobre el dolor en fibromialgia y la osteoartritis.(AU)
Objective: To analyse the current literature on theeffects of hydrotherapy on pain in people diagnosed withosteoarthritis or fibromyalgia.Methodology: The search for information for theliterature review was carried out using the followingdatabases: PubMed, Science Direct, Scopus, GoogleScholar, Scielo and Clinicalkey, comprised between2010 and 2021, although the articles chosen rangefrom 2011 onwards, taking into account the inclusionand exclusion criteria, 20 articles were chosen for thereview, selecting 11 for fibromyalgia and 9 for osteo-arthritis.Results: The structure of the interventions were sim-ilar with a duration of 45 to 60 minutes, starting withjoint mobility or stretching, then general strengtheningor aerobic exercise, and ending with stretching. In thefibromyalgia articles a significant improvement on painwas found in 90.9 % of the studies and 88.8 % for theosteoarthritis studies.Conclusions: Hydrotherapy has short-term benefitson pain in fibromyalgia and osteoarthritis.(AU)
Subject(s)
Humans , Male , Female , Hydrotherapy , Osteoarthritis , Fibromyalgia , Therapeutics , Joint Diseases , Pain , ColombiaABSTRACT
Edwards syndrome or trisomy 18 is a complex entity that involves the musculoskeletal, craniofacial, cardiovascular, and neurological systems. Its genetics are varied, presenting both in a complete and mosaic type. Survival rarely exceeds the first year of life. Its phenotype characterization is not pathognomonic, so karyotype is essential for diagnosis, prenatally by amniocentesis and cordocentesis by FISH technique. We present the case of an eight-year-old girl who has survived with this condition despite presenting tetralogy of Fallot and serious cardiac malformations. Diagnosis began with prenatal screening ultrasound at 16 weeks and detailed ultrasound, with amniocentesis and amniotic fluid karyotype, with a result of 47 XX+18. She has been treated by multiple medical specialties, due to musculoskeletal, joint, neurological, metabolic, and cardiovascular complications that have limited her quality of life. The management of these patients requires a multidisciplinary medical team, and counseling for parents should include aspects related to survival, frequent complications, and risk-benefit to be evaluated before subjecting the minor to complex or corrective surgical interventions.
El síndrome de Edwards o trisomía 18 es una entidad compleja, con afectaciones en los sistemas musculoesquelético, craneofacial, cardiovascular y neurológico. Su genética es variada, presentándose tanto de manera completa como en mosaicismo. Es infrecuente que la supervivencia supere el primer año de vida. Su caracterización fenotípica no es patognomónica, por lo cual el cariotipo es fundamental para el diagnóstico prenatal por medio de amniocentesis y cordocentesis mediante técnica de hibridación fluorescente in situ. Se presenta el caso de una paciente de ocho años que ha sobrevivido con esta condición, a pesar de presentar tetralogía de Fallot acompañada de malformaciones cardíacas graves. El diagnóstico comenzó por ecografía de tamizaje prenatal a las 16 semanas y ecografía de detalle, con amniocentesis y cariotipo de líquido amniótico, con resultado 47 XX+18. Ha sido tratada por múltiples especialidades médicas, debido a complicaciones osteomusculares, articulares, neurológicas, metabólicas y cardiovasculares que han limitado su calidad de vida. El manejo de estos pacientes requiere un equipo médico multidisciplinario. La consejería a los padres debe incluir aspectos relativos a la sobrevida, complicaciones frecuentes y riesgo-beneficio a evaluar antes de someter al menor a intervenciones quirúrgicas complejas o correctivas.
Subject(s)
Heart Defects, Congenital/physiopathology , Quality of Life , Trisomy 18 Syndrome/physiopathology , Amniocentesis , Child , Female , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/therapy , Humans , Prenatal Diagnosis , Trisomy 18 Syndrome/diagnosis , Trisomy 18 Syndrome/therapy , Ultrasonography, PrenatalABSTRACT
El síndrome de Edwards o trisomía 18 es una entidad compleja, con afectaciones en los sistemas musculoesquelético, craneofacial, cardiovascular y neurológico. Su genética es variada, presentándose tanto de manera completa como en mosaicismo. Es infrecuente que la supervivencia supere el primer año de vida. Su caracterización fenotípica no es patognomónica, por lo cual el cariotipo es fundamental para el diagnóstico prenatal por medio de amniocentesis y cordocentesis mediante técnica de hibridación fluorescente in situ. Se presenta el caso de una paciente de ocho años que ha sobrevivido con esta condición, a pesar de presentar tetralogía de Fallot acompañada de malformaciones cardíacas graves. El diagnóstico comenzó por ecografía de tamizaje prenatal a las 16 semanas y ecografía de detalle, con amniocentesis y cariotipo de líquido amniótico, con resultado 47 XX+18. Ha sido tratada por múltiples especialidades médicas, debido a complicaciones osteomusculares, articulares, neurológicas, metabólicas y cardiovasculares que han limitado su calidad de vida. El manejo de estos pacientes requiere un equipo médico multidisciplinario. La consejería a los padres debe incluir aspectos relativos a la sobrevida, complicaciones frecuentes y riesgo-beneficio a evaluar antes de someter al menor a intervenciones quirúrgicas complejas o correctivas.
Edwards syndrome or trisomy 18 is a complex entity that involves the musculoskeletal, craniofacial, cardiovascular, and neurological systems. Its genetics are varied, presenting both in a complete and mosaic type. Survival rarely exceeds the first year of life. Its phenotype characterization is not pathognomonic, so karyotype is essential for diagnosis, prenatally by amniocentesis and cordocentesis by FISH technique. We present the case of an eight-year-old girl who has survived with this condition despite presenting tetralogy of Fallot and serious cardiac malformations. Diagnosis began with prenatal screening ultrasound at 16 weeks and detailed ultrasound, with amniocentesis and amniotic fluid karyotype, with a result of 47 XX+18. She has been treated by multiple medical specialties, due to musculoskeletal, joint, neurological, metabolic, and cardiovascular complications that have limited her quality of life. The management of these patients requires a multidisciplinary medical team, and counseling for parents should include aspects related to survival, frequent complications, and risk-benefit to be evaluated before subjecting the minor to complex or corrective surgical interventions.
Subject(s)
Humans , Female , Child , Quality of Life , Trisomy 18 Syndrome/physiopathology , Heart Defects, Congenital/physiopathology , Prenatal Diagnosis , Ultrasonography, Prenatal , Trisomy 18 Syndrome/diagnosis , Trisomy 18 Syndrome/therapy , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/therapy , AmniocentesisABSTRACT
OBJECTIVE: Glycomacropeptide (GMP) is a bioactive peptide derived from milk that has been reported to exhibit a range of anti-inflammatory and immunomodulatory properties. The aim of this study was to analyze the prophylactic effect of GMP administration on airway inflammation and remodeling in an experimental model of asthmatic rat. METHODS: Animals treated orally with or without GMP (500 mg/kg/day) were ovalbumin-sensitized and -nebulized and several indicators of Th2 response, airway structural changes and inflammatory cells recruitment were evaluated. RESULTS: Treatment with GMP prior and during asthma development resulted in reduction of allergen-specific IgE titers in serum and blood eosinophilia. Also, GMP substantially suppressed the recruitment of inflammatory cells to bronchoalveolar compartment. Histological studies demonstrated that GMP markedly inhibits eosinophils infiltration, goblet cells hyperplasia and collagen deposit in lung tissue. The latter effect was related with an inhibition in transforming growth factor-ß expression. In addition, expression of interleukin-5 and -13 were substantially inhibited in lung while that of interleukin-10 was increased. CONCLUSION: Our results suggest that administration of GMP may prevent the development of an excessive Th2 response in asthma and effectively ameliorates the progression of the disease.
