ABSTRACT
Background. Nowadays, neoadjuvant chemotherapy (nCT) in breast cancer is more and more standardized, not only in advanced tumours but also in those for which there is an attempt to achieve breast-conserving surgery. In literature, we can find evidences of the relationship between several types of tumours and systemic inflammatory response. Our objective is to analyse the prognostic value of blood parameters (lymphocytes, neutrophils, monocytes, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-monocyte ratio (NMR) and neutrophil-to-lymphocyte ratio (NLR) in breast cancer (BC) patients treated with nCT. Methods. A retrospective cohort of 150 breast cancer patients treated with nCT and subsequently with surgery was analysed. Data about the patients, histology, response to chemotherapy and peripheral blood values of lymphocytes, monocytes and neutrophils was collected, and used to calculate the LMR, NMR and NLR. Univariate and multivariate analyses were performed for the variables to see the relationship of the ratios to disease-free survival (DFS) and overall survival (OS). Results. Patients with high LMR (≥5.46) and low NLR (<3.33) were associated with a lower percentage of relapse (P = 0.048 and P = 0.015, respectively) and, above all, NLR was associated with a better survival (P = 0.024), being those factors that predict a good progress. Conclusion. High LMR and low NLR can be considered as favourable prognostic factors in BC patients treated with nCT (AU)
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Subject(s)
Humans , Female , Breast Neoplasms/pathology , Antineoplastic Agents/pharmacokinetics , Lymphocytes , Monocytes , Neutrophils , Breast Neoplasms/drug therapy , Neoadjuvant Therapy/statistics & numerical data , Retrospective Studies , Biomarkers, Tumor/analysis , PrognosisABSTRACT
BACKGROUND: Nowadays, neoadjuvant chemotherapy (nCT) in breast cancer is more and more standardized, not only in advanced tumours but also in those for which there is an attempt to achieve breast-conserving surgery. In literature, we can find evidences of the relationship between several types of tumours and systemic inflammatory response. Our objective is to analyse the prognostic value of blood parameters (lymphocytes, neutrophils, monocytes, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-monocyte ratio (NMR) and neutrophil-to-lymphocyte ratio (NLR) in breast cancer (BC) patients treated with nCT. METHODS: A retrospective cohort of 150 breast cancer patients treated with nCT and subsequently with surgery was analysed. Data about the patients, histology, response to chemotherapy and peripheral blood values of lymphocytes, monocytes and neutrophils was collected, and used to calculate the LMR, NMR and NLR. Univariate and multivariate analyses were performed for the variables to see the relationship of the ratios to disease-free survival (DFS) and overall survival (OS). RESULTS: Patients with high LMR (≥5.46) and low NLR (<3.33) were associated with a lower percentage of relapse (P = 0.048 and P = 0.015, respectively) and, above all, NLR was associated with a better survival (P = 0.024), being those factors that predict a good progress. CONCLUSION: High LMR and low NLR can be considered as favourable prognostic factors in BC patients treated with nCT.
Subject(s)
Biomarkers, Tumor/blood , Breast Neoplasms/blood , Neoadjuvant Therapy , Adult , Aged , Biomarkers, Tumor/immunology , Breast Neoplasms/drug therapy , Breast Neoplasms/mortality , Chemotherapy, Adjuvant , Disease-Free Survival , Female , Humans , Kaplan-Meier Estimate , Leukocyte Count , Middle Aged , Monocytes , Neutrophils , Prognosis , Proportional Hazards Models , Retrospective StudiesABSTRACT
Introducción. La litiasis intrahepática, muy frecuente en países del sudeste asiático, es rara en países europeos y se asocia a estenosis y dilataciones de los radicales biliares, lo que puede obligar a realizar resecciones hepáticas para su resolución definitiva.Pacientes y método. Presentamos 4 pacientes con litiasis intrahepática que requirieron una hepatectomía para su resolución. En un caso se asoció a enfermedad de Caroli del lóbulo hepático derecho que precisó hepatectomía derecha, y los 3 casos restantes presentaron estenosis de radicales segmentarios del lóbulo hepático derecho y precisaron segmentectomías para su resolución. La litiasis intrahepática se manifestó clínicamente por un cólico hepático en un caso y una colangitis aguda en 3 casos. La exploración preoperatoria e intraoperatoria fundamental para el diagnóstico fue la ecografía. Las exploraciones radiológicas (tomografía computarizada, resonancia magnética y técnicas con contraste, preoperatorias e intraoperatorias) fueron importantes para el diagnóstico definitivo.Resultados. No existió mortalidad intraoperatoria ni postoperatoria. Dos pacientes presentaron un absceso subfrénico resuelto con drenaje radiológico. No ha recurrido la litiasis intrahepática tras un seguimiento medio de 29 meses (rango, 17-38).Conclusiones. La hepatectomía resuelve definitivamente aquellos pacientes con litiasis intrahepática cuando existen estenosis y/o dilataciones lobares o segmentarias. Si preoperatoriamente no se sospecha la litiasis intrahepática, los pacientes pueden requerir varias intervenciones para su resolución definitiva. (AU)
