ABSTRACT
BACKGROUND: Currently, both the American Thyroid Association and the European Thyroid Association recommend preoperative preparation with Lugol's Solution (LS) for patients undergoing thyroidectomy for Graves' Disease (GD), but their recommendations are based on low-quality evidence. The LIGRADIS trial aims to provide evidence either to support or refute the systematic use of LS in euthyroid patients undergoing thyroidectomy for GD. METHODS: A multicenter randomized controlled trial will be performed. Patients ≥18 years of age, diagnosed with GD, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy will be eligible for inclusion. Exclusion criteria will be prior thyroid or parathyroid surgery, hyperparathyroidism that requires associated parathyroidectomy, thyroid cancer that requires adding a lymph node dissection, iodine allergy, consumption of lithium or amiodarone, medically unfit patients (ASA-IV), breastfeeding women, preoperative vocal cord palsy and planned endoscopic, video-assisted or remote access surgery.Between January 2020 and January 2022, 270 patients will be randomized for either receiving or not preoperative preparation with LS. Researchers will be blinded to treatment assignment. The primary outcome will be the rate of postoperative complications: hypoparathyroidism, recurrent laryngeal nerve injury, hematoma, surgical site infection or death. Secondary outcomes will be intraoperative events (Thyroidectomy Difficulty Scale score, blood loss, recurrent laryngeal nerve neuromonitoring signal loss), operative time, postoperative length of stay, hospital readmissions, permanent complications and adverse events associated to LS. CONCLUSIONS: There is no conclusive evidence supporting the benefits of preoperative treatment with LS in this setting. This trial aims to provide new insights into future Clinical Practice Guidelines recommendations. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03980132.
ABSTRACT
Parathyroid carcinoma usually develops in association with primary hyperparathyroidism. Only 18 cases have been reported in patients with secondary or tertiary renal hyperparathyroidism. We present a case of parathyroid carcinoma arising on transplanted parathyroid tissue after total parathyroidectomy for renal hyperparathyroidism.
Subject(s)
Hyperparathyroidism, Secondary/surgery , Parathyroid Glands/pathology , Parathyroid Neoplasms/pathology , Parathyroidectomy/methods , Postoperative Complications , Humans , Male , Middle Aged , Parathyroid Glands/surgery , Parathyroid Neoplasms/surgeryABSTRACT
El carcinoma de paratiroides se presenta comúnmente en pacientes con hiperparatiroidismo primario. Es muy rara su descripción en pacientes con hiperparatiroidismo secundario o terciario y se ha descrito sólo en 18 casos en la literatura médica. Presentamos un caso de un paciente afectado de carcinoma de paratiroides sobre tejido trasplantado tras una paratiroidectomía total por hiperparatiroidismo nefrogénico (AU)
Parathyroid carcinoma usually develops in association with primary hyperparathyroidism. Only 18 cases have been reported in patients with secondary or tertiary renal hyperparathyroidism. We present a case of parathyroid carcinoma arising on transplanted parathyroid tissue after total parathyroidectomy for renal hyperparathyroidism (AU)
