ABSTRACT
BACKGROUND/OBJECTIVES: Dietary patterns and biomarkers of inflammation have been scarcely associated. The aim was to assess dietary factors associated with subclinical inflammation among girls. SUBJECTS/METHODS: Fasting blood samples were collected from 12- to 17-year old girls (n=219) to measure adiponectin, leptin, tumor necrosis factor-alpha, plasminogen activator inhibitor 1 (PAI-1), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) levels. Body mass index (BMI) and waist-to-height ratio (WHtR), and food intake were also measured. Western (WDP) and Mediterranean (MDP) dietary patterns were identified. RESULTS: BMI and WHtR were associated with adiponectin, leptin and hs-CRP (the last, only associated with BMI). Intakes of ß-carotene equivalents and vitamin C were associated with adiponectin; saturated fatty acids (SFA), vitamin A, manganese and selenium with leptin; linoleic acid with PAI-1; and oleic acid and vitamin E with IL-6. Selenium was inversely associated with adiponectin, whereas magnesium was positively associated with IL-6. MDP was associated with higher plasma concentrations of adiponectin (ß=0.174, P<0.05); after adjustment for BMI, associations were not significant (ß=0.144, P=0.076). WDP was negatively associated with adiponectin (ß=-0.177, P<0.05) and positively with IL-6 (ß=0.183, P<0.05). CONCLUSIONS: Subclinical inflammation is detectable with increasing BMI and also WHtR. Measures of adiposity (BMI and WHtR) are significant predictors of adiponectin, leptin and hs-CRP. Dietary patterns per se have a small role in affecting inflammatory markers among adolescents.
Subject(s)
Diet , Inflammation/physiopathology , Adiponectin/blood , Adolescent , Ascorbic Acid/administration & dosage , Biomarkers/blood , Body Height , Body Mass Index , C-Reactive Protein/analysis , Child , Fatty Acids/administration & dosage , Female , Humans , Inflammation/blood , Interleukin-6/blood , Leptin/blood , Linoleic Acid/administration & dosage , Manganese/administration & dosage , Oleic Acid/administration & dosage , Plasminogen Activator Inhibitor 1/blood , Selenium/administration & dosage , Tumor Necrosis Factor-alpha/blood , Vitamin A/administration & dosage , Vitamin E/administration & dosage , Waist Circumference , beta Carotene/administration & dosageABSTRACT
BACKGROUND/OBJECTIVES: The alarming increase in obesity worldwide is of concern, owing to the associations of obesity with metabolic syndrome (MetS), which has been associated with a proinflammatory state characterized by elevated plasma concentrations of several markers of inflammation. The aim of this study was to assess levels of inflammatory markers and their association with MetS among adolescents. SUBJECTS/METHODS: A random sample of adolescents (n=362, 143 boys and 219 girls, 12-17 years) was interviewed, anthropometrically measured and provided a fasting blood sample. Circulating levels of adiponectin, leptin, tumour necrosis factor-alpha, plasminogen activator inhibitor 1 (PAI-1), interleukin-6 and high-sensitivity C-reactive protein were measured. The association between inflammatory markers and sex, age, body mass index (BMI) status, MetS, physical activity and blood pressure was also calculated. RESULTS: Adiponectin levels are inversely associated and leptin levels are directly associated with MetS and BMI, but directly with gender (females show higher levels than boys), and PAI-1 levels are directly associated with MetS, among adolescents. CONCLUSIONS: Leptin, adiponectin and PAI-1 may be used as biomarkers to predict MetS among adolescents.
Subject(s)
Adiponectin/blood , Down-Regulation , Leptin/blood , Metabolic Syndrome/blood , Plasminogen Activator Inhibitor 1/blood , Up-Regulation , Adolescent , Biomarkers/blood , Body Mass Index , C-Reactive Protein/analysis , Child , Cross-Sectional Studies , Female , Humans , Hypertension/etiology , Inflammation Mediators/blood , Male , Mediterranean Islands/epidemiology , Metabolic Syndrome/diagnosis , Metabolic Syndrome/epidemiology , Metabolic Syndrome/immunology , Overweight/complications , Overweight/epidemiology , Predictive Value of Tests , Prevalence , Spain/epidemiologyABSTRACT
BACKGROUND AND AIMS: To determine the prevalence of metabolic syndrome (MetS) and its components in adolescents in the Balearic Islands, in the western Mediterranean Sea. METHODS AND RESULTS: A cross-sectional nutritional survey was carried out in the Balearic Islands (2007-2008). A random sample (n=362, 143 boys and 219 girls) of the adolescent population (12-17 years) was interviewed, anthropometrically measured, and provided a fasting blood sample. The MetS prevalence was determined by the ATP III criteria adapted for youths. Adherence to the Mediterranean diet (MD) was defined according to a score constructed considering the consumption of MD components: high monounsaturated fatty acids (MUFA)/saturated fatty acids (SFA) ratio, moderate ethanol consumption, high legume, cereals and roots, fruit, vegetables, and fish consumption, and low meat and milk consumption. The overall MetS prevalence was 5.8% (boys 10.5%, girls 2.7%). MetS criteria were met by 10.0% of overweight, 45.5% of obese and in 1.8% of normal weight adolescents. Half of the adolescents (49.7%) had at least one MetS component. None of the adolescents had all five risk factors. High triglyceride level (90.5%), hypertension (85.7%), low HDL cholesterol level (78.9%) and central obesity (71.4%) were common among adolescents with MetS whereas hyperglycaemia (0.6%) was infrequent. Higher adherence to MD was associated with significantly lower odds ratio of having MetS, but half of the adolescents showed high adherence to MD. CONCLUSION: MetS prevalence was significant among adolescents in the Balearic Islands, especially among obese boys. A high adherence to MD in adolescents was associated with a low prevalence of the MetS criteria.
