ABSTRACT
Bimolecular layer of phospholipids and cholesterol is the structural base of the vesicular agglomerates of the lithogenic bile, as was shown by the methods of scanning and transmission electron microscopy. There are two morphologic versions of the lipid texture in agglomerates: a/multilayer's vesicles resembles to multilamellar liposomes b/aggregate of the bilayer's lamellae's growing in package. The authors considers that the lamellae's phase together with lipophilic and hydrophilic substances is not only predecessor, but also main structural component of the cholesterol bile stones.
Subject(s)
Bile/cytology , Cholelithiasis/pathology , Cholesterol , Humans , Microscopy, Electron , Microscopy, Electron, ScanningSubject(s)
Duodenal Ulcer/metabolism , Duodenum/metabolism , Intestinal Mucosa/metabolism , Lipid Peroxidation , Vitamin E/metabolism , Adult , Aged , Antioxidants , Humans , Middle AgedABSTRACT
Scanning electron microscopy was employed to study cholelithic microstructure. Irrespective of the chemical composition, the gall-stones demonstrated the presence of a cementing matrix composed of micellar-vesicular particles occurring either in aggregates or regularly spreading along the facets about the surface of crystalloid structures. There appeared to be a close relationship between the latter and the particles which are, viz., vesicles, responsible for the plane and margin epitaxy of the cryslalloid structures. Any cholesterol deposits are lipoprotein-like particles or their derivatives, appearing as micellar-vesicular particles in case of choleliths.