BRAIN INTEGRATED ACTIVITY IN MEDICAL STUDENTS UNDER CONDITIONS OF ADAPTATION TO PSYCHOEMOTIONAL STRESS.

According to the results of the study the development of adaptation to psychoemotional stress, which is considered as an emotional stress in medical students during the first three years of study, has a dynamic and multifactorial character. The degree of adaptation processes' manifestation is analyzed and it is shown that it correlates with the intellectual capacity, which is based on the features of the brain integrative activity. During the study, the brain integrative activity was studied according to the information indicators of the higher (memory, internal time tracking) and central (stabilometric reaction, functional asymmetry degree) levels. The objective indicator of the internal time tracking study is an individual minute duration (IMD). Students who have been marked an adequate adaptation to psychoemotional stress in the process of increasing the duration of training at the university, showed an increase in the accuracy of internal time. This was observed in the increase of 70-80% of students with normative values of IMD.

ULTRASTRUCTURAL CHANGES IN THE ORGANS OF THE IMMUNE SYSTEM UNDER THE INFLUENCE OF XENOBIOTICS.

Nowadays scientific achievements in various areas of lives have caused the creation of more and more «foreign body substances¼ known as xenobiotics. As it is widely accepted that human health is a product of both genetics and the environment; and premise that also holds true for the immune system with unclear morphogenetic aspect, so we selected the purpose of our work as detection of ultrastructural changes in the spleen and thymus under the influence of tryglycidyl ether of polyoxypropylenetriol (TEPPT) and propylene glycol (PP). Subacute experiment has been performed on the matured male rat's with administration of 1/10 LD50 and 1/100 LD50 of TEPPT and PP during 7 days, 15 days, 30 days and 45 days. Obtained materials of spleen and thymus have been investigated with ultramicroscopic and histological examination. Detection of cellular density has been performed. On the base of obtained results we can conclude that structure of spleen and thymus is susceptible to influence of TEPPT and PP. Ultrastructural changes in those organs of the immune system are characterized by margination of chromatin in nuclei, appearance of pronounced invaginations of karyolemma till fragmentation of nuclei; condensed, wrinkled cytoplasm, dilatation of mitochondria, vacuolization of cytoplasm. Such changes are manifestation of hydropic dystrophy and apoptosis development with resulting in reducing of cellular density in 45 days more pronounced under TEPPT influence with 1/10 LD50 dose: in mantle zone of spleen follicle from 171.1±4.1to 123.7±10.8 cells/104 µm2, in marginal zone of spleen follicle from 104.6±3.8 to 79.4±9.7, in cortical zone of thymus from 180.1±3.9 to 128.3±9.1, in medullar zone of thymus from 137.4±3.7 to 98.6±8.3.

MICROSCOPIC FEATURES OF THE SPLEEN UNDER THE INFLUENCE OF LAPROXIDES.

Rapid technology growth and its implementation in all spheres of the people's lives dictates the necessity for thorough study of the influence of different chemicals on human's health. This study was undertaken to elucidate the structural changes that occur in the matured rats' spleen experimentally induced by selected xenobiotic, so, purpose of our work was detection of microscopic peculiarities of the spleen under the influence of laproxides. In subacute experiment were uncovered organometric alterations of the matured male rat's spleen after the administration of 1/10 LD50 of polyether-tryglycidyl ether of polyoxypropylene triol (TEPPT). The study was performed on 72 outbreed WAG male matured rats with the weight 200±10g. Histological slides were studied with performing morphometric and statistical methods. We revealed changes of morphologiс data in comparison to control data which shows reactivity of the spleen in response to the induced xenobiotic. The received and analyzed data demonstrate the morphological changes of the spleen, specifically changes of the linear dimensions and weight of the spleen due to the influence of the TEPPT. The spleen is very sensitive to the effects of xenobiotics, in particular, TEPPT that is even reflected in its grossly (weight and linear dimensions) and histological features (reliable changes of the of the white pulp area of the spleen from 17.87±1.04% to 27.37±1.71%, diameter of lymphatic follicles from 426.59±11.18 µm to 382.31±11.73 µm, width of the mantle zone from 45.73±1.08 µm to 37.18±2.29 µm, width of the marginal zone from 81.32±1.79 µm to 74.63±2.08 µm, width of the periarterial zone from 88.73±2.69 µm to 97.24±2.61 µm).

INTERSYSTEM INTEGRATION IN TERMS OF THE EDUCATIONAL PROCESS IN THE INITIAL COURSES OF HIGHER MEDICAL SCHOOL.

The study was conducted as part of research work «Features of integrative and autonomic functions in the process of adaptation to the intellectual, emotional and physical stress" of the Department of Physiology of KhNMU. The aim of this work was to study the intersystem relationships that are the basis for the development of the body's resistance to the effects of stress factors, i.e., the development of adaptation syndrome in medical students. The object of the study were 217 students of 1-3 courses, which were examined in terms of the educational process. The features of intersystem integration the cardiorespiratory system on the basis of conjugation and integration of brain activity indeces based on intellectual efficiency in terms of a correction test. The study of the psychophysiological indicators complex in dynamics (3 years) revealed the formation of chronic emotional stress in medical students, the severity of which depends on the individual psychophysiological status of students. It was set that the formation of the adaptive optimum with psychoemotional stress occurs in only in 40% of students. Most of the students (60 %) indicate or initially insufficient adaptive capabilities, or an excessive rate, which naturally lead to psychological and autonomic disturbances in the organism.