Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Eksp Klin Farmakol ; 56(2): 16-8, 1993.
Article in Russian | MEDLINE | ID: mdl-8348027

ABSTRACT

The effect of the calcium channel blockers cinnarizine (20 mg/kg) and flunarizine (10 mg/kg) on hexobarbital sleeping time in rats has been studied. We have found that cinnarizine when applied intraperitoneally once 1 h or 4 h before hexobarbital and repeatedly for 5 days once daily prolongs sleeping time significantly. When cinnarizine has been introduced simultaneously with phenobarbital (60 mg/kg) for 5 days once daily the sleeping time that was expected to be shortened by phenobarbital only has been obtained to return to control values. Flunarizine has not been found to affect sleeping time significantly either alone or in the presence of phenobarbital. Latencies have not been altered by any of both agents.


Subject(s)
Cinnarizine/pharmacology , Flunarizine/pharmacology , Hexobarbital/pharmacology , Sleep/drug effects , Animals , Drug Interactions , Male , Rats , Rats, Wistar , Reaction Time/drug effects , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...