ABSTRACT
The results of the analysis of the present epidemiological situation in diphtheria in the Maritime Territory are presented. The data on absolute and intensive characteristics, death rate due to this infection, the vaccination status of diphtheria patients, as well as the results of the study of the level and intensity of antidiphtheria immunity in the healthy population of the territory. The study revealed that the defects of collective antidiphtheria immunity correlated with morbidity rate among adults and children. Adults aged 40-50 years and children aged 6-7 years were regarded as risk groups; among them the highest proportion of nonimmune persons and the highest diphtheria morbidity rate were registered. Stabilization achieved by the present moment was the result of the mass immunization of the adult population, ensuring the necessary coverage (92%) of vaccination in 1995.
Subject(s)
Diphtheria/epidemiology , Adolescent , Adult , Age Distribution , Antibodies, Bacterial/blood , Child , Child, Preschool , Corynebacterium diphtheriae/immunology , Diphtheria/immunology , Diphtheria/prevention & control , Diphtheria Toxoid/immunology , Humans , Incidence , Middle Aged , Random Allocation , Seroepidemiologic Studies , Siberia/epidemiologyABSTRACT
Fluorescent angiographic examination of the choroid and retinal circulation in 43 patients with arterial hypertension of different origin without signs of hypertensive retinopathy with low and normal values of the fibrinolytic activity of the lacrimal fluid (FALF) revealed a correlation between disorders of the choroid circulation (ischemic zones, delayed time of contrast staining of the choroid) and reduction of FALF. The results indicate that a reduction of FALF may be regarded as a prerequisite for the development of circulatory disorders in the choroid.
Subject(s)
Choroid/blood supply , Fibrinolysis/physiology , Hypertension/physiopathology , Tears/physiology , Adult , Female , Fluorescein Angiography , Fundus Oculi , Humans , Hypertension/metabolism , Hypertension/pathology , Lacrimal Apparatus/metabolism , Male , Microcirculation/physiopathology , Middle AgedABSTRACT
Initial stages of the rat liver ultrastructural rearrangements after local cooling of the liver tissue down to 93 K and 243 K have been studied by means of light microscopic analysis, transmission electron microscopy and freeze-substitution. The main stages in the development of cell dystrophic changes during cryonecrosis formation in the cooled area have been outlined, the crystallization behaviour und cooling conditions studied has been described.
Subject(s)
Cold Temperature , Liver/ultrastructure , Animals , Liver/cytology , Liver/pathology , Male , Necrosis , Rats , Rats, Inbred StrainsSubject(s)
Glaucoma, Open-Angle/blood , Lipid Peroxides/blood , Aged , Female , Humans , Intraocular Pressure , Lipids/blood , Male , Middle Aged , Oxidation-Reduction , Spectrophotometry, UltravioletABSTRACT
Electron-microscopic and stereometric study of hepatocyte ultrastructure with local liver cooling to -30 degrees C have been performed using the method of vital fixation by rat liver perfusion. Quantitative and qualitative data obtained testify to the presence of destructive changes in hepatocytes immediately after thawing expressed in hyaloplasm lightening, formation of cavities in cytoplasm and injury of mitochondria membrane and endoplasmic reticulum integrity. Changes in nuclear structure of hepatocytes and Kupffer cells (widening of nuclear pores and channels in condensed chromatine, as well as the presence of ribosomal complexes in the nucleus and edge position of the nucleolus) may be connected with the beginning of the reparation process.
