ABSTRACT
56 patients at the age of 18-60 years with severe trauma were examined. Influence of the polyelectrolytic (Reamberin)solution on an acid-base state, osmolarity and electrolytic composition of plasma in the acute posttraumatic period was evaluated. It was found that patients, who was treated by isotonic sodium chloride solution and Ringer's solution, had metabolic acidosis and hyperchloremia. In contrast, in the reamberin group 82% of patients had lower concentrations of chloride and had nothing acid-base disturbances on the second day after trauma. Reamberin didn't influence on plasma osmolarity and the rate of metabolic alkalosis during the acute period of a trauma.
Subject(s)
Acidosis/drug therapy , Fluid Therapy/methods , Meglumine/analogs & derivatives , Multiple Trauma/drug therapy , Succinates/therapeutic use , Acid-Base Equilibrium/drug effects , Acidosis/etiology , Adolescent , Adult , Chlorine/blood , Erythrocyte Transfusion , Female , Humans , Isotonic Solutions , Male , Meglumine/administration & dosage , Meglumine/therapeutic use , Middle Aged , Multiple Trauma/blood , Multiple Trauma/complications , Multiple Trauma/metabolism , Ringer's Solution , Succinates/administration & dosage , Trauma Severity Indices , Treatment Outcome , Young AdultABSTRACT
The review presents contemporary look at the problem of the cascade of pathophysiological reactions in patients with severe mechanical trauma. In the article described in detail changes hormonal and metabolic parameters in this category patients. In severe cases this leads to the development the syndrome of hypermetabolism-hypercatabolizm. Patients with this syndrome have a resistance to the introduction of exogenous nutrients. Syndrome of hypermetabolism-hypercatabolizm play a leading role in the pathogenesis of critical condition, it determines the outcome of the disease in general. The article studied in detail the pathogenesis of the processes occurring in critically ill patients, taking into account the pathogenetic mechanism of development are possible solutions to this complex issue.
