ABSTRACT
Atopic dermatitis (AD) is the most common chronic dermatitis in children. The influence of AD on quality of life of parents of children with AD was studied using the Family Dermatology Life Quality Index (FDLQI). Fifty children with AD were included in the study (age range 2-24 months) together with their parents. Children's AD was found to influence the quality of life of both parents; however, it had a more significant influence on quality of life of mothers than that of fathers (mean FDLQI: 17.1 ± 5.3 vs. 14.7 ± 5.8 points; p < 0.001). Due to the children's AD, mothers spent more time caring for them and carried out more household duties. Childhood AD had a greater impact on quality of life of fathers through influence on their work or education. The influence of AD on the quality of life of family members is significant, and this should be taken into account in the therapeutic process.
Subject(s)
Cost of Illness , Dermatitis, Atopic/psychology , Fathers/psychology , Mothers/psychology , Quality of Life , Age of Onset , Child, Preschool , Dermatitis, Atopic/diagnosis , Female , Humans , Infant , Male , Surveys and QuestionnairesABSTRACT
BACKGROUND: Mycoplasma pneumoniae is an important cause of upper and lower respiratory tract infections. Cough and tracheobronchitis are the commonest features of M. pneumoniae infection but diagnosis based on clinical symptoms that may be due to other respiratory pathogens is impossible. Thus laboratory testing for M. pneumoniae is particularly important. Correct and rapid diagnosis of M. pneumoniae infections is of prime importance to introduce appropriate antibiotic treatment. OBJECTIVES: Evaluation of the incidence of IgM and IgG antibodies specific to M. pneumoniae among children with pneumonia and/or chronic cough. MATERIAL AND METHODS: Serum samples from 148 children with a history of chronic cough (lasting at least one month), recurrent respiratory tract infections, allergic rhinitis, and/or inflammatory changes on X-chest ray. First, all sera were screened for specific anti-M. pneumoniae antibodies using agglutination test following the detection of specific IgM and IgG anti-M. pneumoniae antibodies using immunoenzymatic assays. RESULTS: Out of the 148 serum samples, 57 (38.5%) gave positive screening results. However, the presence of M. pneumoniae-specific IgM and/or IgG antibodies was confirmed by immunoenzymatic assays in only 30 (52.6%) of these 57 positive samples. These results indicated that in as many as 27 (47.4%) out of the 57 serum samples screened, false-positive results occurred. CONCLUSIONS: Evaluation of acute- and convalescent-phase sera is necessary to make possible accurate interpretation of the serological testing results.
Subject(s)
Antibodies, Bacterial/blood , Cough/microbiology , Pneumonia, Mycoplasma/microbiology , Adolescent , Child , Child, Preschool , Chronic Disease , Humans , Immunoenzyme Techniques , Immunoglobulin G/blood , Immunoglobulin M/blood , InfantABSTRACT
The new derivative of well-known triterpene, oleanolic acid: methyl 3-octanoyloxyiminoolean-12-en-28-oate 5, was synthesized by the action of caprylic acid on methyl oleanolate 3-oxime in the presence of dicyclohexylcarbodiimide in dioxane. The molecular structure of the obtained product 5 was confirmed by spectral methods. The acute toxicity, locomotor activity, and the dose-dependent analgesic activity were studied. In addition, the effect of compound 5 on morphine-induced analgesic activity, the dose-dependent anti-inflammatory activity and the effect of the compound on diclofenac anti-inflammatory activity study were performed. The results proved a low toxicity (LD50 > 2 g/kg) of the tested product 5, which affected neither vertical nor horizontal locomotor activity in the given range of doses. The triterpene 5 also produced centrally mediated (morphine-like) analgesic action; however, only in the highest dose. The synergistic analgesic activity of 5 and morphine in the doses of 30.0 and 300.0mg/kg was found. Compound 5 expressed the anti-inflammatory action which did not affect the anti-inflammatory activity of diclofenac after their combined administration.
Subject(s)
Analgesics/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Drug Eruptions/drug therapy , Oleanolic Acid/analogs & derivatives , Pain/drug therapy , Analgesics/chemical synthesis , Analgesics/pharmacology , Animals , Anti-Inflammatory Agents/chemical synthesis , Anti-Inflammatory Agents/pharmacology , Carrageenan , Drug Synergism , Edema/chemically induced , Edema/drug therapy , Male , Mice , Morphine/pharmacology , Motor Activity/drug effects , Oleanolic Acid/chemical synthesis , Oleanolic Acid/pharmacology , Oleanolic Acid/therapeutic use , Rats , Rats, Wistar , Toxicity Tests, AcuteABSTRACT
A series of novel compounds were synthesized in reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H(1) NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti-inflammatory activities were experimentally verified.
