ABSTRACT
O lítio ainda é a primeira escolha no tratamento profilático do transtorno bipolar. Porém, aproximadamente 1/3 dos pacientes com o curso clássico do transtorno bipolar, näo respondem de maneira adequada o lítio. Mesmo após a introduçäo da carbamazepina e do ácido valpróico, 10 a 20 por cento dos pacientes continuam refratários as terapêuticas preconizadas. Através desse artigo os autores discutem novas possibilidades de tratamento para o transtorno bipolar refratário
Subject(s)
Humans , Bipolar Disorder , Carbamazepine , Lithium , Antipsychotic AgentsABSTRACT
Este estudo com a nefazodona, um novo inibidor seletivo de recaptaçäo de serotonina(ISRS), tem o objetivo maior de mostrar o perfil de interaçöes medicamentosas, droga com droga, assim como com o CYP-450, mostrando os principais efeitos colaterais e açöes terapêuticas principais
Subject(s)
Humans , Male , Female , Cytochrome P-450 Enzyme System/drug effects , Cytochrome P-450 Enzyme System/therapeutic use , Depression/diet therapy , Depression/psychology , Depression/therapyABSTRACT
Este artigo tem o escopo de mostrar a moclobemida, um inibidor reversível da MAOA apresenta um baixo perfil de interaçöes medicamentosas, principalmente no que tange à farmacodinâmica ocupando lugar de destaque na prática clínica para o tratamento de depressäo e alguns transtornos ansiosos
Subject(s)
Humans , Animals , Adult , Anxiety Disorders/therapy , Depression/therapy , Monoamine Oxidase Inhibitors/pharmacokinetics , Monoamine Oxidase Inhibitors/pharmacology , Monoamine Oxidase Inhibitors/therapeutic use , Antidepressive Agents/pharmacology , Psychotropic Drugs/metabolismABSTRACT
BACKGROUND: The objective of this study is to measure the association between protein-energy malnutrition (PEM) in children and their mothers' mental health, in a low income area in the city of Embú, São Paulo, Brazil. METHODS: A case-control study was performed. Cases were 60 moderately and severely malnourished children (Gomez criteria) selected from two primary health care units. Controls consisted of 45 eutrophic children attending the same units. The main outcome measure was for the mothers to present a mental health score > 6 according with the 'Adult Psychiatric Morbidity Questionnaire' (QMPA), a psychiatric screening instrument. RESULTS: Of mothers of children with PEM, 63% and 38% of mothers in the control group were QMPA positive: odds ratio (OR) = 2.8 (95% confidence interval [CI]: 1.2-6.9). Of PEM children, 27% had low birthweight (LBW = < 2500 g) and 6% of the control group had LBW. Interactions were found between: mothers' mental health and number of children (with > or = 4 children: OR = 20.0 [95% CI: 2.1-274.2], with < or = 3 children: OR = 1.6 [95% CI: 0.6-4.5), as well as mothers' mental health and maternal age (in women > 30: OR = 12.5 [95% CI: 2.0-93.4], in women < or = 30: OR = 1.5 [95% CI: 0.5-4.4]. CONCLUSIONS: Mothers of children with PEM showed a higher rate of mental disturbances than mothers of eutrophic children. Unlike LBW, maternal age and number of children interact with mothers' mental health, increasing the association. Management of poor mental health may lead to mothers being better caretakers of their children and this may have a positive impact on PEM.
