Subject(s)
Dermatitis, Exfoliative/congenital , Dermatitis, Exfoliative/pathology , Nevus, Sebaceous of Jadassohn/diagnosis , Psoriasis/diagnosis , Adult , Dermatitis, Exfoliative/genetics , Diagnosis, Differential , Female , Histocompatibility Antigens Class I/genetics , Histocompatibility Antigens Class II/genetics , Humans , Nevus, Sebaceous of Jadassohn/congenital , Psoriasis/congenitalSubject(s)
Histocompatibility Antigens Class II/genetics , Pemphigus/genetics , Brazil/ethnology , Cross-Sectional Studies , Gene Frequency/genetics , Genetic Predisposition to Disease/ethnology , Genetic Predisposition to Disease/genetics , Heterozygote , Homozygote , Humans , Netherlands/ethnology , Pemphigus/ethnologyABSTRACT
BACKGROUND: Fissured tongue (FT) is a clinical condition manifested by numerous little furrows on the tongue's surface. Previously, the authors observed an association with HLA-C×06 in psoriasis (PS) and benign migratory glossitis (BMG); however, HLA-C was not surveyed in FT. OBJECTIVE: This study investigated the association between HLA alleles and FT. METHODS: Thirty-three FT bearers were studied, after evaluation of criteria for inclusion. These patients did not present PS, BMG or any other conditions associated with FT. The control group (CG) was composed of 561 individuals with HLA-A, 560 individuals with HLA-B, 168 individuals with HLA-C, 564 individuals with HLA-DRB1 and 390 individuals with HLA-DQB1. Samples from these individuals were processed to extract DNA. The HLA classes I and II were determined using the reverse line blot technique. The frequencies of HLA antigens found in patients were compared with the CG using Fisher's exact test. RESULTS: The comparison of the frequencies of HLA antigens found in the patient groups and in CG revealed no association with any of the alleles studied, except for HLA-A*01, which exhibited a decreased frequency in patient groups. HLA-C*06 was detected in 7.57% of FT patients and 10.42% of the CG (not significant). CONCLUSION: The lack of association of FT with HLA-C*06 reinforces the proposal that this disease does not have a common genetic factor in the triad of BMG, FT and PS.
Subject(s)
Alleles , HLA Antigens/genetics , Tongue, Fissured/genetics , Brazil , Case-Control Studies , Humans , Tongue, Fissured/immunologyABSTRACT
The authors investigated the relationship between dermatophytosis and ABO blood groups through blood typing, identification of isolated dermatophytes and specific cellular immune response of 40 individuals carriers of this mycosis. They verified that the fungus Trichophyton rubrum, isolated from 54.5% of the patients, was more frequent in individuals belonging to blood group A. The cellular immune response, evaluated through the trichophytin antigen, was positive in 25% of the studied patients; the presence of immediate reactions (30 minutes) was verified in 35%. The blood group distribution among patients with dermatophytosis and control groups was, respectively: 47.5% X 36% in group A, 40% X 50% in group O, 12. 5% X 11% in group B. Even though the authors have found a higher number of patients belonging to blood group A infected by T. rubrum, these results suggest that there is no statistical evidence that these individuals are more susceptible to dermatophytosis.
