ABSTRACT
OBJECTIVE: In chronic therapies, the less number of adverse effects (AE) to drugs is decisive to improve the rate of performance and reach the protective objective. We can make comparisons in the rate of tolerance of antihypertensive drugs (AD) if we study all of them with the same method in patients with real hypertension. METHODS: Analyzed 922 hospitalized hypertensive patients looking for adverse effects (AE) reported systematically and spontaneously form, the causality must to excel in two algorithms the uncertain grade. RESULTS: 13.47% of antihypertensive drugs presented an AE, beta-blockers presented more AE than diuretics and angiotensin-converting enzyme (ACE) inhibitors. CONCLUSIONS: The AD haven't the same AE neither feature nor frequency. If to dependent on a poor fulfillment, we lose the protective effectiveness, the application independently of the economic cost isn't right.
Subject(s)
Antihypertensive Agents/adverse effects , Aged , Aged, 80 and over , Chi-Square Distribution , Drug Therapy, Combination , Drug Tolerance , Female , Humans , Hypertension/complications , Hypertension/drug therapy , Interviews as Topic/methods , Male , Middle Aged , Risk Factors , Spain , Surveys and QuestionnairesABSTRACT
Objetivo: La menor presencia de reacciones adversas a medicamentos (RAM), en terapias crónicas, se hace decisiva para mejorar el grado de cumplimiento y alcanzar el objetivo protector. Estudiar con el mismo método todos los fármacos antihipertensivos (FA) en hipertensos reales, permite realizar comparaciones en el grado de tolerancia. Métodos: Entrevistamos 922 pacientes hipertensos hospitalizados en búsqueda de RAM relatadas de forma espontanea y sistemática, la causalidad debía superar el grado de dudoso con dos algoritmos. Resultados: El 13,47 porciento de los antihipertensivos presentó una RAM, los bloqueadores beta presentaron más RAM que los diuréticos e inhibidores de la enzima conversiva de la angiotensina. Conclusiones: No todos los FA tienen el mismo perfil ni frecuencia de RAM. Si por condicionar un peor cumplimiento, se pierde la eficiencia protectora, sea cual sea su coste no tiene sentido su uso (AU)
Subject(s)
Aged , Female , Male , Middle Aged , Aged, 80 and over , Humans , Antihypertensive Agents , Chi-Square Distribution , Drug Therapy, Combination , Drug Tolerance , Hypertension/complications , Hypertension/drug therapy , Interviews as Topic/methods , Surveys and Questionnaires , Risk Factors , Spain , Antihypertensive Agents/adverse effectsSubject(s)
Hemangioma/pathology , Spinal Cord Neoplasms/pathology , Adolescent , Humans , Male , NeckABSTRACT
The hydatidosis disease, which is caused by the larva of the granulosus equinococcus, is still a common zoonosis in countries like Spain. The observation of a calcified hydatid cyst of the liver in an asymptomatic patient suggest a very long clinical latency period of the disease. Acute complications have been reported. We present the case of a patient with clinical symptoms of nonresolving pneumonia and an old calcified hydatid cyst of the liver. The first approach to the diagnosis of community-acquired pneumonia was inconclusive. The high clinical suspect of equinococcus infection added to the bronchoscopy findings, computed tomographic (CT) study and serological test, permitted the correct preoperative diagnosis. The surgical removal confirmed the diagnosis of transphrenic migration of a hydatid cyst ruptured to the bronchial tree.
Subject(s)
Calcinosis/complications , Echinococcosis, Hepatic/complications , Echinococcosis, Pulmonary/parasitology , Pneumonia/parasitology , Diaphragm , Female , Humans , Middle AgedABSTRACT
The cranial nerves, due to its location, are not infrequently involved in the nasopharyngeal neoplasm evolutionary course. In this paper we describe two cases in which the neoplastic infiltration in both cavernous sinuses brought the appearance of an acute bilateral ophthalmolegia on. This symptomatology meant, in the first case, the onset of disease. In the second one, it was the reason of consultation. Later we discuss the topographic location of the damages in both cavernous sinuses considering the observed neurological shortcomings. Finally we approach a short revision of the causes of bilateral ophthalmoplegia found in literature, as well as an evaluation of different radiological diagnosis methods for this kind of damages.
Subject(s)
Nasopharyngeal Neoplasms/complications , Ophthalmoplegia/etiology , Acute Disease , Female , Humans , Middle AgedSubject(s)
Drug Therapy , Hospitalization , Aged , Algorithms , Data Interpretation, Statistical , Female , Humans , Male , Middle Aged , SpainABSTRACT
We studied in two groups of epileptic patients the thyroid alterations induced by anticonvulsant therapy (AC). Group I (28 cases): T4t and TSH were measured before and after 3 and 6 months on treatment with AC. Group II (75 cases on treatment): thyroid hormones were measured only once. In cases with low value of T4t or high TSH a TRH test and FT4 determination were performed. In group I two cases with low T4t were found after six months on treatment (7%), one of them with low FT4 and both with normal TSH. In group II we found 6 cases (7.8%) with low T4t and FT4, two of them with high TSH. It was not possible argue against factor and the low incidence reported argue against rutinary screening. Anycase, this screening will never be performed before the lag time observed (6 months).
