ABSTRACT
Authors evaluated the activity of c-AMP in the CSF as the biochemical marker for evaluation of epileptic seizure activity in patients with epilepsy. The impact of monitored phenytoin treatment on c-AMP activity in CSF was investigated. It was shown that the general tonic-clonic seizures cause a significant concentration increase of c-AMP in CSF. Monitored phenytoin treatment had a stabilizing effect on c-AMP activity in CSF.
Subject(s)
Cyclic AMP/cerebrospinal fluid , Epilepsy, Tonic-Clonic/cerebrospinal fluid , Phenytoin/administration & dosage , Adolescent , Adult , Cyclic AMP/antagonists & inhibitors , Depression, Chemical , Drug Monitoring , Epilepsy, Tonic-Clonic/drug therapy , Humans , Middle Aged , Time FactorsABSTRACT
Modern views on the role of c-AMP and c-CMP in the regulation of metabolism and function of the neuron and synaptic transmission are presented. A hypothesis is put forward of the participation of these cyclic nucleotides in the control of epileptogenic focus through modulation of the resting potential of the neuron.
Subject(s)
Anticonvulsants/therapeutic use , Brain/metabolism , Cyclic AMP/metabolism , Epilepsy/etiology , Receptors, Cyclic AMP/metabolism , Brain/drug effects , Cyclic AMP/antagonists & inhibitors , Depression, Chemical , Epilepsy/drug therapy , Humans , Receptors, Cyclic AMP/drug effectsABSTRACT
The authors report a case of coexistence of Eales disease and multiple sclerosis in which signs of perivenous retinitis preceded by 25 years the appearance of neurological changes. Considering the similarity in the course of both disease and the histological character of perivascular changes the authors suggest presence of a common causative factor and pathological mechanism of the development of clinical changes.
Subject(s)
Multiple Sclerosis/complications , Phlebitis/etiology , Retinal Hemorrhage/etiology , Retinal Vein , Humans , Male , Middle Aged , Multiple Sclerosis/classificationABSTRACT
The aim of the reported study was an assessment of the effectiveness of high doses of methylprednisolone in the treatment of active exacerbation and its effect on the natural course of multiple sclerosis. The study was carried out on 24 patients with clinically certain disease, who were divided, according to the treatment given to them, into two subgroups: treated with methylprednisolone and treated with prednisone. The treatment was conducted by the double blind method. The statistical analysis of the results obtained in this material showed that in patients with acute and severe exacerbation of the disease methylprednisolone administration in high doses caused a rapid regression of paralysis and paresis and improved motor efficiency. However, an evaluation of the results after a year from treatment termination showed in both subgroups a progression of clinical changes and increased motor deficiency. This suggests that treatment with corticosteroids has no significant effect on the course of multiple sclerosis.
Subject(s)
Methylprednisolone/administration & dosage , Multiple Sclerosis/drug therapy , Adult , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Male , Middle Aged , Multiple Sclerosis/rehabilitation , Prednisone/administration & dosage , Prospective Studies , Time Factors , Work Capacity EvaluationABSTRACT
A case acute intermittent porphyria is described in which the inappropriate antidiuretic hormone secretion syndrome developed masked by rapidly increasing sensorimotor polyneuropathy.
Subject(s)
Inappropriate ADH Syndrome/etiology , Liver Diseases/complications , Porphyrias/complications , Acute Disease , Adult , Female , HumansABSTRACT
The authors carried out experiments with application of transmission and scanning electron microscopy in the examinations of the cell sediment of the cerebrospinal fluid obtained by membrane filtration. The method made possible ultrastructural examination of fluids with low cell count. The observed cells had natural shapes and well preserved morphological details.
