1.
Org Lett
; 24(33): 6230-6235, 2022 08 26.
Article
in English
| MEDLINE
| ID: mdl-35950978
ABSTRACT
A practically useful protocol for the asymmetric synthesis of artificial ß-aryl-substituted cysteine derivatives was developed through sequential Pd(II)-catalyzed Heck cross-coupling with aryl iodides and hydrothiolation reaction with various alkyl thiols in the presence of triethylamine taking place in the ligand sphere of a robust and bench-stable chiral dehydroalanine Ni(II) complex. The subsequent acidic decomposition of the single diastereomeric Ni(II) complexes led to the target enantiopure cysteine derivatives.