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Antiseptic myramistin possesses the strong anti-HIV properties.

Kryvorutchenko, Iu L; Kryvosheïn, Iu S; Andronovs'ka, I B; Marennykova, S S; Stepanova, L H; Nosyk, D N; Kalnina, L B; Rud'ko, A P.

Mikrobiol Z ; 58(5): 90-2, 1996.

Article in English | MEDLINE | ID: mdl-8993062

ABSTRACT

The anti-HIV properties of cation detergent myramistin were studied. The dose-dependent slowing down both of the HIV antigens accumulation in supernatants and the virus-dependent cell death was shown at myramistin concentrations 30 micrograms/ml and 50 micrograms/ml in the MT-4 cell line. Simultaneous addition of the trace amount of the detergents and HIV-1 to the cells of Jurkat-tat line did not stimulate the HIV p24 production for 4 days of the experiment.

Subject(s)

Anti-Infective Agents, Local/pharmacology , Antiviral Agents/pharmacology , Benzalkonium Compounds/pharmacology , HIV-1/drug effects , Cyclic N-Oxides/pharmacology , Detergents/pharmacology , Dose-Response Relationship, Drug , HIV Core Protein p24/analysis , HIV Core Protein p24/drug effects , HIV-1/growth & development , HIV-1/immunology , Humans , Jurkat Cells , Leukemia, Lymphoid , Tumor Cells, Cultured , Virus Cultivation

ABSTRACT

Subject(s)

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