1.
Neurology
; 63(11): 2146-8, 2004 Dec 14.
Article
in English
| MEDLINE
| ID: mdl-15596766
ABSTRACT
Five hundred seventy-six patients with suspected stiff-person syndrome (SPS) underwent immunocytochemistry (ICC). Of these, 286 underwent radioimmunoassay (RIA) for glutamic acid decarboxylase (GAD) antibodies; 116 were GAD antibody positive by one or both tests. Ninety-six percent of those positive by ICC had RIA values several standard deviations above normal. RIA did not correlate with age or illness duration. Marked elevations of RIA for GAD antibodies were characteristic of ICC-confirmed SPS, and modest elevations were not.
Subject(s)
Autoantibodies/blood , Autoantigens/immunology , Autoimmune Diseases/immunology , Glutamate Decarboxylase/immunology , Radioimmunoassay , Stiff-Person Syndrome/immunology , Age Factors , Antibody Specificity , Autoantibodies/immunology , Autoimmune Diseases/blood , Blotting, Western , Cohort Studies , Humans , Immunohistochemistry , Predictive Value of Tests , ROC Curve , Sensitivity and Specificity , Stiff-Person Syndrome/blood , Time Factors , gamma-Aminobutyric Acid/biosynthesis , gamma-Aminobutyric Acid/physiology
2.
Haematologica
; 66(4): 461-88, 1981 Aug.
Article
in English
| MEDLINE
| ID: mdl-6797881
