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1.
Transplant Proc ; 39(3): 759-60, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17445592

ABSTRACT

This study was undertaken with the aim to analyze the clinical relevance of posttransplant anti-HLA and anti-major histocompatibility complex class I related chain A (MICA) antibodies in response to living related donor renal transplantation. A total of 185 consecutive post-renal transplant recipient serum samples were analyzed for the detection of anti-HLA and MICA antibodies using enzyme-linked immunosolvent assay techniques. Patients carrying both anti-HLA as well as anti-MICA antibodies (MICA(+)/HLA(+)) were the worst affected, showing significantly poorer graft survival compared with the MICA-/HLA-negative group (17% vs 89%, chi(2) = 19.63, P = .000). Similarly, patients with only MICA antibodies or those with only HLA antibodies also had significantly lower graft survival (P = .035 and P = .001, respectively) as compared to the nonsensitized group. The study illustrated that posttransplant monitoring antibodies to both MICA as well as HLA could be good predictors of renal allograft failure.


Subject(s)
HLA Antigens/immunology , Histocompatibility Antigens Class I/immunology , Isoantibodies/blood , Kidney Transplantation/immunology , Family , Graft Rejection/epidemiology , Graft Rejection/immunology , Humans , Immunoglobulin G/blood , Living Donors , Monitoring, Immunologic
2.
Clin Transpl ; : 211-7, 2007.
Article in English | MEDLINE | ID: mdl-18637472

ABSTRACT

The objective of this study was to evaluate the donor-specific antibody repertoire against T and B cells and monocytes, as well as the non-donor anti-HLA, and MICA (MHC class I-related chain A) antibodies in recipients of the live related donor renal transplantation. Sera collected before and after transplantation were tested by ELISA for the presence of HLA class I- and class II-specific antibodies and by Luminex MICA single-antigen bead assay for the detection of MICA antibodies. Patients having a combination of both anti-HLA and MICA antibodies had worse graft survival and more rejection episodes as compared to the group without antibodies. Further, presence of IgG antibodies against the donor cells (T, B & monocytes) led to a compromised graft survival along with higher incidence of acute rejection as compared to the negative groups. These results suggest that a comprehensive assessment of anti-donor antibody repertoire and monitoring of anti-HLA, MICA antibodies following transplantation is a useful exercise to detect the sensitization status of the recipient and this can prove to be of immense prognostic value in renal transplantation.


Subject(s)
Graft Rejection/immunology , Graft Survival/immunology , HLA Antigens/immunology , Histocompatibility Antigens Class I/immunology , Kidney Transplantation/immunology , Antibody Specificity , Biomarkers/blood , Histocompatibility Testing , Humans , Immunoglobulin G/blood , Immunoglobulin G/immunology , Isoantibodies/blood , Isoantibodies/immunology , Living Donors , Retrospective Studies , Transplantation, Homologous , Treatment Outcome
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