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1.
Clin Interv Aging ; 10: 1445-9, 2015.
Article in English | MEDLINE | ID: mdl-26379429

ABSTRACT

Cerebrovascular disease is one of the most common causes of cerebrovascular morbidity and mortality in developed countries; up to 40% of acute ischemic strokes in young adults are cryptogenic in nature - that is, no cause is determined. However, in more than half of these patients, patent foramen ovale (PFO) is seen along with an increased incidence of atrial septal aneurysm (ASA). The following is a report of an interesting case: a 68-year-old man with ASA and transient cerebral ischemia. Transesophageal echocardiography (TEE) showed the presence of ASA; a test with microbubbles derived from a mixture of air and saline or colloids pointed out a shunt on the foramen ovale following Valsalva's maneuver. The patient underwent percutaneous transcatheter closure of the interatrial communication by an interventional cardiologist. TEE and transcranial Doppler or TEE with the microbubbles test are the recommended methods for detecting and quantifying intracardiac shunts, both at rest and following Valsalva's maneuver. In patients following the first event of transient ischemic attack, and without clinical and anatomical risk factors (such as the presence of ASA, PFO, and basal shunt), pharmacological treatment with antiplatelets or anticoagulants is closely recommended. On the contrary, in patients following the first event of transient ischemic attack, or a recurrent event during antiplatelet treatment, the percutaneous closure of PFO is recommended.


Subject(s)
Foramen Ovale, Patent/complications , Heart Aneurysm/complications , Heart Septal Defects, Atrial/complications , Ischemic Attack, Transient/etiology , Aged , Echocardiography, Transesophageal , Foramen Ovale, Patent/diagnostic imaging , Heart Aneurysm/diagnostic imaging , Heart Aneurysm/therapy , Heart Septal Defects, Atrial/diagnostic imaging , Heart Septal Defects, Atrial/therapy , Humans , Incidence , Ischemic Attack, Transient/diagnostic imaging , Male , Percutaneous Coronary Intervention , Ultrasonography, Doppler, Transcranial , Valsalva Maneuver
2.
Arch Gerontol Geriatr ; 55(3): 706-8, 2012.
Article in English | MEDLINE | ID: mdl-22115873

ABSTRACT

A 66 year-old man was brought to the emergency room (ER) for syncope and sphincter incontinence; syncope duration was about 15 min. Similar short duration episodes had been referred by his relatives during the last months, following small traumas; no seizures had been registered. Patient told he was affected with BS, having already been diagnosed 5 years before, after performing an electrocardiogram (ECG) highly suggestive for it. He had performed an electrophysiologic study, which had not shown any sustained ventricular arrhythmias after scheduled stimulation. This finding together to the lack of symptoms had suggested a conservative treatment, notwithstanding that familiar history documented his father's sudden death. Patient was also affected with hypertension and gastroesophageal reflux disease. Clinical examination did not suggest any significant findings. Laboratory tests, supra aortic Doppler ultrasound, electroencephalogram (EEG) and brain CT were normal. ECG showed sinus rhythm with a heart frequency of 82 bpm, QRS axis was normal, as well as atrioventricular conduction. ST coved-type elevation with right bundle branch block pattern and repolarization abnormalities were found. Holter ECG and Doppler echocardiography were also performed. The onset of syncope in presence of BS suggested the evaluation of this case report together with electrophysiolgists and neurologists. Therefore, an implantable cardioverter defibrillator (ICD) was implanted through left subclavian vein. He was discharged eight days after hospitalization, diagnosis was "Syncope in patient affected with BS, hypertension". Arrhythmogenic risk stratification is necessary; the indication for implanting this device is obvious in symptomatic patients, whereas it is controversial in patients presenting only ECG patterns of BS. In conclusion, the above mentioned case report rises remarkable diagnostic and therapeutic issues. The finding of BS in a patient with syncope indicates the opportunity of implanting a defibrillator and only clinical experience and common opinions may help doctors in taking the most appropriated, often difficult, decisions.


Subject(s)
Brugada Syndrome/therapy , Syncope/therapy , Aged , Brugada Syndrome/diagnosis , Brugada Syndrome/diagnostic imaging , Brugada Syndrome/physiopathology , Bundle-Branch Block/diagnosis , Bundle-Branch Block/diagnostic imaging , Bundle-Branch Block/physiopathology , Bundle-Branch Block/therapy , Defibrillators, Implantable , Echocardiography, Doppler , Electrocardiography , Gastroesophageal Reflux/diagnosis , Heart Rate , Humans , Hypertension/diagnosis , Hypertension/diagnostic imaging , Hypertension/physiopathology , Hypertension/therapy , Male , Syncope/diagnosis , Syncope/diagnostic imaging , Syncope/physiopathology , Treatment Outcome
3.
Clin Interv Aging ; 5: 71-3, 2010 Apr 07.
Article in English | MEDLINE | ID: mdl-20396636

ABSTRACT

The present study describes a case of laxative-induced rhabdomyolysis in an elderly patient. An 87-year-old woman was hospitalized for the onset of confusion, tremors, an inability to walk, and a fever that she had been experiencing for 36 hours. She often took high dosages of lactulose and sorbitol syrup as a laxative (about 70 g/day). During her physical examination, the patient was confused, drowsy, and she presented hyposthenia in her upper and lower limbs, symmetric and diffuse moderate hyporeflexia, and her temperature was 37.8 degrees C. Laboratory tests revealed severe hyponatremia with hypokalemia, hypocalcemia, hypochloremia, and metabolic alkalosis. Moreover, rhabdomyolysis markers were found. The correction of hydroelectrolytic imbalances with saline, potassium and sodium chlorure, calcium gluconate was the first treatment. During her hospitalization the patient presented acute delirium, treated with haloperidol and prometazine chloridrate intramuscularly. She was discharged 12 days later, after resolution of symptoms, and normalized laboratory tests. Over-the-counter drugs such as laxatives are usually not considered dangerous; on the other hand, they may cause serum electrolytic imbalance and rhabdomyolysis. A careful monitoring of all the drugs taken by the elderly is one of the most important duties of a physician since drug interactions and their secondary effects may be fatal.


Subject(s)
Laxatives/adverse effects , Rhabdomyolysis/chemically induced , Aged, 80 and over , Dose-Response Relationship, Drug , Female , Humans , Laxatives/administration & dosage , Nonprescription Drugs/adverse effects , Rhabdomyolysis/diagnosis , Rhabdomyolysis/physiopathology
4.
Pain Med ; 8(6): 531-4, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17716328

ABSTRACT

INTRODUCTION: Glossodynia is a multifunctional disorder characterized by painful sensations in the mouth and throat and especially on the tongue. It is commonly cured by long-term therapy with systemic regimens of anxiolytics, antidepressants, and anticonvulsants. CASE: We report here the case of a 65-year-old woman with a 4-month history of glossodynia. Clinical and laboratory evaluations performed the diagnosis of idiopathic glossodynia, and several treatments with carbamazepine and then with gabapentin induced the development of serious adverse reaction. Only treatment with topiramate has been able to induce a complete improvement of symptoms. DISCUSSION: The pathogenesis of idiopathic glossodynia remains unclear, since it recently has been suggested as a possible neuropathic basis of burning mouth syndrome, demonstrating an altered excitability in the trigeminal nociceptive pathway at peripheral and/or central nervous system level. The various mechanisms of topiramate, which act at different neural transmission levels, blocking sodium and calcium channels, enhancing GABA concentration, and decreasing glutamate function at postsynaptic site, may explain the effects of topiramate in our patient. CONCLUSION: Therefore, we suggest that topiramate could represent a useful therapeutic option in the treatment of glossodynia.


Subject(s)
Anticonvulsants/therapeutic use , Fructose/analogs & derivatives , Glossalgia/drug therapy , Aged , Female , Fructose/therapeutic use , Humans , Pain Measurement , Topiramate
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