ABSTRACT
The effect of some chemotherapeutics, on the course of acute toxoplasmosis in experimentally infected mice was studied. Obtained results showed that, praziquantel, levamisole had no effect on acute toxoplasmosis, while trimethoprim-sulphamethoxazole and clindamycin showed some prophylactic effect on acute toxoplasmosis in mice.
Subject(s)
Toxoplasmosis, Animal/drug therapy , Animals , Chloroquine/therapeutic use , Clindamycin/therapeutic use , Drug Combinations/therapeutic use , Levamisole/therapeutic use , Mice , Praziquantel/therapeutic use , Sulfamethoxazole/therapeutic use , Trimethoprim/therapeutic use , Trimethoprim, Sulfamethoxazole Drug CombinationABSTRACT
The effect of excess heat and cold on chronic toxoplasmosis was studied on rats. That was evident from the average increase in body weight, the effect on blood picture, deleterious effect of the pathology recorded in various organs, increased Toxoplasma brain cyst count, long persistence of parasites in the viscera, high antibody titre by I.H.A.T. in infected animals exposed to excess heat and its decrease in animals exposed to excess cold.
