Heterogeneity of non-cystic-fibrosis bronchiectasis in multiethnic Singapore: A prospective cohort study at a tertiary pulmonology centre

INTRODUCTION@#Non-cystic fibrosis bronchiectasis (NCFB) is a highly heterogenous disease. We describe the clinical characteristics of NCFB patients and evaluate the performance of Bronchiectasis Severity Index (BSI) in predicting mortality.@*METHODS@#Patients attending the bronchiectasis clinic between August 2015 and April 2020 with radiologically proven bronchiectasis on computed tomography were recruited. Clinical characteristics, spirometry, radiology, microbiology and clinical course over a median period of 2.4 years is presented.@*RESULTS@#A total of 168 patients were enrolled in this prospective cohort study. They were predominantly women (67.8%), Chinese (87.5%) and never-smokers (76.9%). Median age of diagnosis was 64 years (interquartile range 56-71) and the most common aetiology was "idiopathic" bronchiectasis (44.6%). Thirty-nine percent had normal spirometries. Compared to female patients, there were more smokers among the male patients (53.8% versus 8.5%, @*CONCLUSION@#The NCFB cohort in Singapore has unique characteristics with sex differences. Over half the patients had a history of haemoptysis. The BSI score is a useful predictor of mortality in our population.

The AsthmaID Tool in Singapore: Four Simple Questions to Detect Patients in need of an Asthma Review by a Specialist

@#A rising prevalence of asthma in Singapore translates to a more considerable patient care burden for general practitioners. Along with diagnosing and managing the treatment of asthma, general practitioners must recognise when referral to a respiratory specialist is necessary. Although mild to moderate asthma is generally manageable in the primary care setting, patients with poorly controlled, difficult-to-treat, or severe asthma may benefit from referral to a specialist. Currently, many of these patients are not receiving optimal care, which places them at risk of asthma exacerbations and unnecessary systemic corticosteroid use. AsthmaID was developed as a tool for general practitioners to identify patients with asthma for whom a specialist evaluation could help improve asthma symptom control and optimise treatment strategies. Using four questions developed by asthma experts and rooted in the Global Initiative for Asthma report, AsthmaID quickly identifies patients who may benefit from a specialist referral without requiring additional patient assessments or testing modalities. Implementation of AsthmaID in clinical practice has the potential to transform the patient care pathway, thereby improving the quality of care for patients with asthma.

Coronavirus Disease 2019 (COVID-19): An Evidence Map of Medical Literature

Since the beginning of the COVID-19 outbreak in December 2019, a substantial body of COVID-19 medical literature has been generated. As of May 2020, gaps in the existing literature remain unidentified and, hence, unaddressed. In this paper, we summarise the medical literature on COVID-19 between 1 January and 24 March 2020 using evidence maps and bibliometric analysis in order to systematically identify gaps and propose areas for valuable future research. The examined COVID-19 medical literature originated primarily from Asia and focussed mainly on clinical features and diagnosis of the disease. Many areas of potential research remain underexplored, such as mental health research, the use of novel technologies and artificial intelligence, research on the pathophysiology of COVID-19 within different body systems, and research on indirect effects of COVID-19 on the care of non-COVID-19 patients. Research collaboration at the international level was limited although improvements may aid global containment efforts.

Asthma Management in the time of COVID-19

@#Asthma is a chronic inflammatory airway disease which results in variable expiratory airflow limitation. While there is currently no evidence that asthma increases the risk of COVID-19 or its severity of illness, new data emerges daily. This article outlines the recommendations by Global Initiative for Asthma (GINA), British Thoracic Society (BTS) and National Asthma Council Australia (NACA) which are relevant to primary care management of asthma in light of the COVID-19 pandemic.

Zero Tolerance Towards Asthma Deaths in Singapore: Role of the Family Doctor

@#Asthma is a common chronic respiratory disease in Singapore and it is the primary cause of chronic respiratory disease burden in childhood and early adulthood. Despite having one of the best healthcare systems in the world, our asthma mortality rates are several folds higher than other first world countries. Most asthma deaths are preventable. We illustrate a case of fatal asthma and highlight some learning points from this case.