ABSTRACT
The Growth Factors (GFs) include a group peptidic molecules, with important trophic, mitotic and cellular differentiation effects in most human tissues. This review encompasses the different types of GFs and their biologic effects on tissues involved in the human reproductive process. The importance of the GF in the embryonic development and the implantation process is also commented. Finally, we assess the participation of the GFs in the pathophysiology of the Polycystic Ovary Syndrome and Endometriosis based on recent investigations. The review permit us appreciate the importance of the GFs as mediators of different hormones (in their secretion and biological effects) and in the regulation of some cellular events. The real value of these GFs in the daily clinical practice is as yet to be established, due to the technical laboratory limitations with respect to their identification and quantification, as well as the lack of more clinical research in humans. The GFs are promising molecules for the treatment of infertiles couples and for the application of the technics of assisted reproduction, in vivo and in vitro.
Subject(s)
Growth Substances/physiology , Reproduction/physiology , Endometrium/embryology , Female , Genitalia, Male/embryology , Humans , Hypothalamo-Hypophyseal System/embryology , Male , Organ Specificity/physiology , Ovary/embryologyABSTRACT
The ectopic pregnancy constitutes a disease that require the most diagnostic accuracy, not only for the biologic importance of its clinical manifestations, but for the sequelae of its treatment too, in relation with the fertility of a patient frequently affected with infertility so far. The increase in its frequency, by multiple factors, including treatment of infertility itself and Assisted Reproduction techniques, make the clinician must be alert and have availability of all diagnostic tools for the establishment of an oportune and conservative treatment, directed to prevent an acute alteration of the hemostasis and a shadowy reproductive future. The present review of the literature about the conservative management of the ectopic pregnancy let us have to know the criteria neccessary for giving the optimum treatment to our patients and offering them a better reproductive future.