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1.
Curr Health Sci J ; 45(2): 156-166, 2019.
Article in English | MEDLINE | ID: mdl-31624642

ABSTRACT

INTRODUCTION: Root resorption is a pathological process characterized by loss of dental root substance, caused by bacterial infections, traumatic injuries or chemical irritation. Root resorption might be accidentally observed on digital panoramic radiography. OBJECTIVE: The objective of the study was to identify characteristic radiological aspects for the different types of root resorption that could be observed on digital panoramic radiography, to make an easier diagnostic of root resorption. MATERIAL AND METHOD: The retrospective study used the X-ray base from the Oral Rehabilitation and Dental Prosthetics Clinic of UMF Craiova to identify the most representative images for different types of root resorption. Digital panoramic radiographies were analysed by two investigators, of which the most suggestive images were selected and described. RESULTS: Digital panoramic radiographies and dental charts of 240 patients were analyzed. 113 cases of root resorption were identified. External inflammatory root resorption (EIRR) was present in 27.07% of studied cases, external cervical root resorption (ECRR) was identified in 10.83% of all studied cases, external replacement root resorption (ERRR) was diagnosed in 7.08% of studied cases and internal root resorption (IRR) was the most rare type of root resorption, with only 2.08% from all studied cases. 16 cases were selected to describe the radiologic features of different types of root resorption, featuring the most interesting images of root resorption evident on digital panoramic radiographies. DISCUSSION: Comparative analyses have been made between our results and the results of other specific studies, with both similar and different values. The radiological features which lead to the diagnostic of each type of RR were highlighted, assessing the causes that caused the lesions, as well as the treatment recommendations. CONCLUSIONS: Digital panoramic radiography is a useful tool to identify root resorption, since it has become the most common radiological investigation for diagnostic in dentistry. Description of radiological aspects of different types of root resorption on panoramic digital radiography allows faster diagnosis. Still, the CBCT may be recommended in some cases to confirm the diagnosis.

2.
Curr Health Sci J ; 45(2): 210-217, 2019.
Article in English | MEDLINE | ID: mdl-31624650

ABSTRACT

We performed a retrospective study on 30 subjects having subclinical depression in the past, involved in a psychotherapeutically process in the last 5 years, which gradually returned with a post-partum depressive episode. The subjects were between 20 and 38 years of age, without psychotic disorders, selected by psychological criteria. Our results showed that for patients' psychopathological profile we found depression, anxiety, affective instability of polymorph aspect, interpretative tendencies. These manifestations correlated significantly with profiles obtained from the Beck and Hamilton scales, often dominated by existential impasse with depressive and anxious tendencies. This study found many risk factors associated with suicidal behavior in patients with post-partum depressive disorder: age under 35, socio-familial and precarious economic status, childhood abuse, disharmonic family relationships, psychotrauma (abuse), emotional instability, accentuated personality, subclinical psychiatric suffering, a heredo-collateral history of mental illness, past history of suicide attempts, low cholesterol levels.

3.
Curr Health Sci J ; 45(1): 96-103, 2019.
Article in English | MEDLINE | ID: mdl-31297269

ABSTRACT

The purpose of the study was to analyze the prevalence of different forms of partial edentulism and the description of the various parameters associated with this disease. Materials and Methods. The study was conducted on a total of 204 subjects who presented themselves at the Clinic of Dental Prosthetics and Oral Rehabilitation Clinic of the Faculty of Dentistry Craiova between October 2015 and June 2016. Results. Of the 204 subjects diagnosed with partial edentulism, 51.47% belonged to the age group of 20-29 years, 52.46% were female and 82.84% came from the urban environment. The most frequent cause of the edentulism was dental caries and their complications. The present study has shown that the partial edentulism forms encountered, especially those of the Kennedy III class, had an increased frequency among the young population, especially in the maxillary arch.

4.
Curr Health Sci J ; 43(1): 54-61, 2017.
Article in English | MEDLINE | ID: mdl-30595855

ABSTRACT

PURPOSE: The aim of the present study was to correlate etiological factors with noncarious cervical lesions in a group of patients from Craiova. MATERIAL AND METHODS: The study was conducted between November 2015 and May 2016 on 50 patients, aged 18-56 years, who addressed to the Oral Rehabilitation Clinic, from the University of Medicine and Pharmacy of Craiova. Patients were divided into two groups: the study group consists of patients who had noncarious cervical dental lesions (NCCLs) and the control group with patients who did not have noncarious cervical lesions. Each patient underwent a clinical examination and completed a questionnaire, referring to eating habits, oral hygiene, vicious habits and personal impressions about the appearance and functionality of his teeth, highlighting the factors involved in the noncarious dental lesions etiology. RESULTS: The study group consisted of 64% women and 36% men. Noncarious cervical lesions were higher in men (72.22%) compared to women (56.25%). Regarding on the tooth brushing method, it has been noted that 34% of patients used a vertical tooth brushing method, 52% were using a circular brushing method, while 14% were practicing a horizontal tooth brushing method. Cervical sensitivity has been detected in 48% of the patients, against 52% who showed no sensitivity. 62% of the participants did not have bruxism, while nighttime/daytime bruxism was found in 38% of the patients. CONCLUSIONS: There are several etiological factors correlated with noncarious cervical lesions, among which are: tooth brushing method, bruxism, eating behaviors.

5.
Rom J Intern Med ; 50(2): 145-53, 2012.
Article in English | MEDLINE | ID: mdl-23326958

ABSTRACT

INTRODUCTION: Regression occurs as a complex interaction between tumor cells and host's immune response; neither biologic mechanisms, nor regression prognostic significance are deciphered to date but promising anti-cancer vaccine strategies were thus developed. METHODS: We analyzed 127 superficial spreading melanomas identifying melanoma with regression (segmentary (SR), partial (PR) and segmentary & partial (SR-PR)) or without regression (AR). Several histopathologic parameters were registered; statistical analysis was performed (level of significance P < 0.05). RESULTS: Regression was present in 52% cases, less frequently in pT4 melanomas. Ulceration and vascular invasion were similarly present in pT2-pT4 melanomas with regression and significantly less in pT1 ones; their incidence increased with stage in AR (P < 0.001). SR and SR-PR melanomas showed significantly more tumor infiltrating lymphocytes within the non-regressed tumor than AR melanomas (P < 0.05). SR melanomas presented significantly less frequent mitoses than PR (P = 0.04), SR-PR (P = 0.04) or AR ones (P = 0.03). Marked inflammation and more numerous melanophages were present regressed areas advanced stage melanomas. More numerous plasma cells were identified in advanced stages; in SR and SR-PR melanomas less numerous plasma cells were present in pT1 than in advanced stages. Vascular hyperplasia was significantly higher in SR than SR-PR cases. CONCLUSIONS: Differences in perception of regression might be the result of labeling with similar name of various processes comprising inflammation and tumor cells destruction; at least in thin melanomas, PR and SR seem to belong to different spectrum of alteration, SR bearing a more favorable potential. Further studies will be performed in order to further elucidate the mechanisms involved in regression in melanoma.


Subject(s)
Melanoma/pathology , Neoplasm Regression, Spontaneous/pathology , Skin Diseases/pathology , Humans , Mitotic Index , Neoplasm Invasiveness , Neoplasm Regression, Spontaneous/physiopathology , Prognosis
7.
Rev Roum Physiol (1990) ; 28(1-2): 45-9, 1991.
Article in English | MEDLINE | ID: mdl-1817669

ABSTRACT

This survey paper presents in a widely accessible form a thermodynamical approach to cancerogenesis and its relevance and utility for molecular biologists; it also suggests a possible definition of information contained in genome and of entropy leaps during cell transformation. A scenario concerning the amplification of an initial alteration in the genomic information during cancerogenesis is proposed, and its implication in our knowledge about spatial and temporal pattern of oncogenes and suppressor genes cooperation during cancerogenesis is discussed.


Subject(s)
Genome, Human , Models, Genetic , Neoplasms/genetics , Cell Transformation, Neoplastic/genetics , Humans , Mathematics , Thermodynamics
9.
Endocrinologie ; 27(1): 49-52, 1989.
Article in English | MEDLINE | ID: mdl-2756329

ABSTRACT

A 57-year old male patient with unilateral exophthalmos was transferred to our hospital from an Ophthalmologic Clinic for suspicion of Graves' disease. Lateral skull X-ray showed the optic holes and orbits within normal limits. Orbital echography and CT scan revealed an intraorbital tumor which on histopathologic examination proved to be malignant lymphoma.


Subject(s)
Exophthalmos/etiology , Lymphoma, Non-Hodgkin/complications , Diagnosis, Differential , Emergencies , Exophthalmos/diagnosis , Exophthalmos/surgery , Humans , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/surgery , Male , Middle Aged , Time Factors
10.
Biol Trace Elem Res ; 16(3): 253-67, 1988 Aug.
Article in English | MEDLINE | ID: mdl-2484553

ABSTRACT

Experimental studies performed on 227 rats showed that Zn-aspartate and Zn-glycinate administered ip lowered the incidence, number, and severity of the reserpine-induced gastric lesions ensuring significant protection indices. Histochemical methods revealed increased amount of mucosal glycoproteins. The activity of dehydrogenases involved in energy metabolism that modulates acid secretion in the parietal cells was depressed. RNA content in the chief cells, as premises of pepsinogen synthesis, was decreased. ATPase reaction in the periglandular capillaries was uniform and stronger, showing an improvement of gastric mucosal microcirculation. Since these histochemical changes were also noted in healthy rats receiving Zn salts, it might be suggested that they are not the mere expression of an anti-ulcer protective effect of zinc, but rather reflect its mechanism of action, relating to the complex metabolic events induced by the trace element. Our results are in agreement with those previously reported concerning the noxious influence of Zn depletion, the accelerated healing of peptic ulcer patients after Zn treatment, and the protective effect of Zn against ulcerogenesis in several experimental models involving different pathomechanisms.


Subject(s)
Aspartic Acid/pharmacology , Gastric Mucosa/drug effects , Glycine/analogs & derivatives , Reserpine/toxicity , Stomach Ulcer/prevention & control , Zinc/pharmacology , Animals , Aspartic Acid/therapeutic use , Gastric Mucosa/metabolism , Glycine/pharmacology , Glycine/therapeutic use , Histocytochemistry , Male , Rats , Rats, Inbred Strains , Stomach Ulcer/chemically induced , Stomach Ulcer/metabolism , Zinc/therapeutic use
11.
Endocrinologie ; 26(1): 59-63, 1988.
Article in English | MEDLINE | ID: mdl-3387888

ABSTRACT

A 27-yr female patient was admitted to the hospital because of secondary amenorrhea and a severe and complex virilization syndrome. The urinary 17-Ks, 17 OHCS and testosterone glucuronide values were greatly increased. The plasma testosterone through very high, was within the normal limits in males (3.52 ng/ml). Urography, echography and CT scan revealed a large right adrenal tumor. Removal of the tumor brought about a considerable clinical improvement: reoccurrence of the menstrual cycle, a progressive decrease in the virilization syndrome and normalization of the urinary 17-Ks, 17-OHCS and of the plasma testosterone.


Subject(s)
17-Hydroxycorticosteroids/urine , 17-Ketosteroids/urine , Adenoma/urine , Adrenal Cortex Neoplasms/urine , Testosterone/analogs & derivatives , Adenoma/pathology , Adrenal Cortex Neoplasms/pathology , Adult , Female , Humans , Testosterone/urine
12.
Endocrinologie ; 24(3): 185-95, 1986.
Article in English | MEDLINE | ID: mdl-2946069

ABSTRACT

Immunoreactive beta-endorphin was determined in the plasma of 37 elderly subjects (73 +/- 7 years of age), in 3 young or young adult subjects without adrenal disease, in 4 women with clinical adrenogenital syndrome, in 1 man with Cushing's disease. Immunoreactive beta-endorphin in plasma was measured by radioimmunoassay in six samples of each subject collected at 4-hour intervals over a 24-hour span. The observation of a circadian rhythm in circulating immunoreactive beta-endorphin with highest values during the late night and early morning hours is extended to elderly subjects in the 8th decade. The beta-endorphin plasma concentrations in the few clinically healthy young adult subjects studied fell within the same range. The circadian variation of the group of elderly subjects was used as reference in the clinical evaluation of plasma beta-endorphin concentrations in patients with pituitary-adrenocortical disorders. The need for circadian rhythm qualified reference values is shown by the observation of the circadian variations of circulating immunoreactive beta-endorphins in the patients with adrenogenital syndrome and Cushing's disease in whom abnormalities in the concentration of circulating beta-endorphin were found at certain circadian stages but not at others.


Subject(s)
Adrenal Hyperplasia, Congenital/blood , Cushing Syndrome/blood , Endorphins/blood , Adolescent , Adult , Aged , Aged, 80 and over , Aging/blood , Circadian Rhythm , Female , Humans , Male , Radioimmunoassay , beta-Endorphin
13.
Endocrinologie ; 23(4): 253-63, 1985.
Article in English | MEDLINE | ID: mdl-3841409

ABSTRACT

A double antibody radioimmunoassay (RIA) system for LH (LH-IEP Kit) was developed using the antigenic similitude of LH with HCG. The first antibody (Ist Ab) is rabbit anti-HCG serum, initial dilution 1:200 000. The tracer is 125I-HCG (code MJ-14 Swierk Poland). The standard curve is calibrated with the reference preparation hLH-Ist-IRP 68/40 kindly offered by WHO. The IInd Ab is pig anti-rabbit IgG serum. The incubation conditions: volume-0.3 ml; time-24 hrs with Ist Ab and 24 hrs with the IInd Ab at ambient temperature. The sensitivity of the RIA system for LH is 1.5 mIU/ml. To validate our RIA system the LH was measured in the serum samples collected from 9 women during the menstrual cycles, from 2 boys during the GnRH test, from 2 amenorrheic women and from 20 children, adolescents and adults with miscellaneous pathologies. In all these samples, parallel measurements of LH and FSH were performed using DDR commercial RIA Kits-SSW. It is to be mentioned that the LH-RIA Kit-SSW is not completely homologous, the Ist Ab being rabbit serum anti-HCG. The results obtained during 4 menstrual cycles, in which the LH peak is observed around the mid point of the interval are: follicular phase 17.92 +/- 5.58 mIU/ml (means +/- SD) with LH-IEP-Kit and 5.51 +/- 2.77 mIU/ml with the LH-SSW-Kit, peak: 26.07 +/- 22.13 mIU/ml and 9.13 +/- 5.60 mIU/ml respectively; luteal phase: 12.55 +/- 5.46 mIU/ml and 3.4 +/- 2.38 mIU/ml, respectively. The LH values observed by the two kits through all 9 menstrual cycles are well correlated ("r" values in the range 0.7-0.9) but high discrepancies were observed in the remaining 3 cycles ("r" between 0.07 and 0.6). These discrepancies as well as those observed in some adolescents with genetic anomalies and in a patient at climacterium are suggesting that the two LH-RIA systems measure not only a common molecular area but also different areas of the LH circulating molecules.


Subject(s)
Chorionic Gonadotropin/immunology , Luteinizing Hormone/blood , Radioimmunoassay/methods , Adolescent , Adult , Animals , Child , Female , Humans , Infertility, Female/blood , Laurence-Moon Syndrome/blood , Luteinizing Hormone/immunology , Male , Menstrual Cycle , Middle Aged , Rabbits , Radioimmunoassay/standards
14.
Endocrinologie ; 23(4): 283-8, 1985.
Article in English | MEDLINE | ID: mdl-4089506

ABSTRACT

A 50-year old female patient was referred to our clinic. She had systolic-diastolic arterial hypertension, oedemas, physical asthenia, weight loss and a large tumor in the left hypochondrium. Hormone assay showed markedly high values of 17 OHCS, 17 KS and testosterone, and high values of estrogens. The tumor was diagnosed as functional adrenal carcinoma. Removal of the tumor and administration of OP'DDD led to the disappearance of all clinical symptoms and normalization of hormonal values.


Subject(s)
Adenocarcinoma/pathology , Adrenal Cortex Neoplasms/pathology , Adenocarcinoma/diagnosis , Adenocarcinoma/therapy , Adrenal Cortex Neoplasms/diagnosis , Adrenal Cortex Neoplasms/therapy , Adult , Combined Modality Therapy , Female , Humans , Mitotane/therapeutic use , Postoperative Care , Tomography, X-Ray Computed
15.
Endocrinologie ; 23(1): 61-6, 1985.
Article in English | MEDLINE | ID: mdl-3992158

ABSTRACT

Pheochromocytoma was diagnosed in a female patient aged 26 with paroxysmal arterial hypertension (AH), profuse sweating, headache, anxiety, tachycardia, transit arrhythmia, high urinary norepinephrine (NE), epinephrine (E) and vanillyl mandelic acid (VMA). Urography with intravenous Odiston revealed a relatively large tumor at the upper pole of the right kidney. Complete removal of the tumor in a 2-step surgical procedure brings apparent clinical and hormonal recovery for 6 years, but then clinical and hormonal relapse occurs through ganglionary metastasis and tumor at the basis of the mesentery. Removal of the metastasis and tumor brings again improvement in the clinical and hormonal picture.


Subject(s)
Adrenal Gland Neoplasms/surgery , Neoplasm Recurrence, Local , Pheochromocytoma/surgery , Adrenal Gland Neoplasms/pathology , Adult , Female , Humans , Mesentery/pathology , Pheochromocytoma/pathology , Postoperative Complications
16.
Endocrinologie ; 22(3): 211-4, 1984.
Article in English | MEDLINE | ID: mdl-6494788

ABSTRACT

A 49-year-old woman at recent climacterium was admitted to our hospital for a dyspeptic-type symptomatology, weight loss, bone pain, moderate polyuric-polydipsic syndrome and in a marked astheno-depressive state. Paraclinical explorations revealed constant hypercalcemia with hypophosphoremia, calciuria, chronic renal failure in the polyuric phase with retention of nitric bases. X-ray films showed diffuse osteoporosis, right nephrocalcinosis and diffuse calcifications of the galactophorous ducts in both breasts. Computerized tomography revealed and surgery confirmed the presence of tumoral tissues on the anterior aspect of the trachea. Histopathologic examination revealed a parathyroid adenoma.


Subject(s)
Breast Diseases/etiology , Calcinosis/etiology , Hyperparathyroidism/complications , Breast Diseases/diagnostic imaging , Calcinosis/diagnostic imaging , Female , Humans , Middle Aged , Parathyroid Neoplasms/complications , Radionuclide Imaging
17.
Rev Stat ; 33(7): 31-7, 1984 Jul.
Article in Romanian | MEDLINE | ID: mdl-12313297

ABSTRACT

PIP: A review of population trends in Romania from 1930 to 1983 is presented. Data are included on total population in selected years, population distribution by size of locality, and rural and urban distribution.^ieng


Subject(s)
Population Dynamics , Population Growth , Demography , Developed Countries , Europe , Europe, Eastern , Geography , Population , Research , Romania , Rural Population , Statistics as Topic , Urban Population
18.
Endocrinologie ; 22(1): 37-45, 1984.
Article in English | MEDLINE | ID: mdl-6369502

ABSTRACT

The authors have studied on 50 patients hospitalized in the Adrenal Pathology unit of the Institute of Endocrinology, the etiopathogeny of arterial hypertension (AH) in hypercorticism and the therapeutic implications, arriving at the conclusion that in 20% of the cases AH was probably due to an increased activity of renin-angiotensin and in 47% to elevated levels of aldosterone. The authors hypothesize that AH in the remaining 30% of the hypercorticism cases in this study is due to other mineralocorticoids in excess and suggest that the treatment should be pathogenic and strictly individualized.


Subject(s)
Adrenocortical Hyperfunction/complications , Aldosterone/blood , Hypertension/etiology , Renin/blood , Adult , Electrolytes/blood , Female , Humans , Male , Middle Aged , Mineralocorticoids/blood
19.
Endocrinologie ; 21(2): 123-9, 1983.
Article in English | MEDLINE | ID: mdl-6867598

ABSTRACT

The investigation was carried out on 66 patients with hypo- or hyperfunctional syndromes of adrenocorticism, hospitalized and treated by our team. The patients were grouped into 5 lots according to their diseases. Lot one consisted of 34 female patients with Cushing's syndrome, lot two of 10 males with Cushing's syndrome, lot three of 10 males with Addison's disease and lot four, of 6 females with androgenic hypercorticism. The morphofunctional disorders of reproduction were followed up clinically and by complex hormone assays, before and after treatment. The incidence of these disorders is very high, and the results of clinical observations and of laboratory data demonstrate that both the excess of adrenocortical hormones and the decrease in their circulating level have a negative influence on the reproduction function or represent a risk factor in cases of pregnancy. By the curative treatment of the adrenal cortex a preventive treatment of abortion and/or sterility is achieved.


Subject(s)
Adrenal Insufficiency/physiopathology , Adrenocortical Hyperfunction/physiopathology , Reproduction , Adult , Female , Gonadal Steroid Hormones/analysis , Gonadotropins, Pituitary/analysis , Humans , Hypothalamus/physiopathology , Male , Middle Aged
20.
Endocrinologie ; 21(1): 43-9, 1983.
Article in English | MEDLINE | ID: mdl-6342118

ABSTRACT

The authors have studied on 25 cases of hypercorticism, one of the mechanisms of producing arterial hypertension, the renin-angiotensin system. The study showed that in only 20% of the cases plasma renin activity was high whereas in the remaining 80% other mechanisms were responsible for the hypertension. In the cases in which the plasma activity of renin was high, by studying the changes in the value of electrolytes we were able to derive some understanding of the mechanism of action of the RA2A system. Thus, the literature data show that sometimes the excess of glucocorticoids causes hypertension by activating directly the RA2A system and concomitently inhibiting the renin-kalikrein system (RKKS) and PgS; at other times, the excess of glucocorticoids is exerted on the same renin-angiotensin system, but via ACTH and ADH, the electrolytes values being those that demonstrate the borrowed mechanism.


Subject(s)
Adrenocortical Hyperfunction/complications , Hypertension/etiology , Renin-Angiotensin System , 17-Ketosteroids/urine , Adult , Aged , Electrolytes/blood , Female , Glucocorticoids/blood , Humans , Hydrocortisone/blood , Male , Middle Aged , Renin/blood
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