Design of a flow modulation device to facilitate individualized ventilation in a shared ventilator setup.

This study aims to resolve the unmet need for ventilator surge capacity by developing a prototype device that can alter patient-specific flow in a shared ventilator setup. The device is designed to deliver a predictable tidal volume (VT), requiring minimal additional monitoring and workload. The prototyped device was tested in an in vitro bench setup for its performance against the intended use and design criteria. The ventilation parameters: VT and airway pressures, and ventilation profiles: pressure, flow and volume were measured for different ventilator and device settings for a healthy and ARDS simulated lung pathology. We obtained VTs with a linear correlation with valve openings from 10 to 100% across set inspiratory pressures (IPs) of 20 to 30 cmH2O. Airway pressure varied with valve opening and lung elastance but did not exceed set IPs. Performance was consistent in both healthy and ARDS-simulated lung conditions. The ventilation profile diverged from traditional pressure-controlled profiles. We present the design a flow modulator to titrate VTs in a shared ventilator setup. Application of the flow modulator resulted in a characteristic flow profile that differs from pressure- or volume controlled ventilation. The development of the flow modulator enables further validation of the Individualized Shared Ventilation (ISV) technology with individualization of delivered VTs and the development of a clinical protocol facilitating its clinical use during a ventilator surge capacity problem.

Evolution of acoustic nonlinearity in outdoor blast propagation from firearms: On the persistence of nonlinear behavior.

Acoustic events exceeding a certain threshold of intensity cannot benefit from a linearization of the governing wave equation, posing an additional burden on the numerical modelling. Weak shock theory associates nonlinearity with the generation of high frequency harmonics that compensate for atmospheric attenuation. Overlooking the persistence of this phenomenon at large distances can lead to mispredictions in gun detection procedures, noise abatement protocols, and auditory risk assessment. The state-of-the-art mostly addresses aircraft jet noise, a stationary and largely random type of signal. The extension of such conclusions to muzzle blasts requires caution in considering their peculiar impulsive and broadband nature. A methodology based on the time and frequency analysis of an experimental dataset of eight calibres intends to find quantitative metrics linked to acoustic nonlinearity in outdoor muzzle blast propagation. Propagating three waveforms (SCAR-L 7.62 mm, Browning 9 mm, and Howitzer 105 mm) up to 300 [m] with the in-house numerical solver based on the nonlinear progressive wave equation, demonstrates that the propagation does not downgrade to truly linear.