Effects of refused melon fruit in Canarana grass ensilage on intake, digestibility, serum biochemistry, performance, carcass characteristics and meat attributes of feedlot lambs.

Ensilage of refused fruit with forage is a viable approach to increase resource use in ruminant feed. The objective of this study was to investigate the impact of ensiling refused melon fruit (RMF) with Canarana grass on the intake, apparent digestibility, serum biochemistry, performance, carcass traits, and meat attributes of feedlot lambs. Four distinct silage treatment types were prepared by ensiling RMF at 0 g/kg (control), 70 g/kg, 140 g/kg, and 210 g/kg (as fed) with Canarana grass. Twenty-eight male Santa Inês lambs (7 lambs per treatment), initially weighing 22.3 ± 1.0 kg at 120 days of age, were distributed in a completely randomized design and confined for a total of 96 days, including a 23-day adaptation period and 73 experimental days in a feedlot. The lambs received the treatment-silage in diets as a complete mixture with a roughage: concentrate ratio of 30:70. The inclusion of RMF in Canarana grass ensilage decreased (P < 0.05) the lambs' intake of dry matter, crude protein and metabolisable energy. The inclusion of RMF in ensilage had a quadratic effect (P < 0.05) on the digestibility of non-fibrous carbohydrates. The serum total protein and cholesterol levels decreased (P < 0.05) with the inclusion of RMF in the ensilage, but we observed no effect on the final weight and average daily gain of the lambs. The feed efficiency increased (P < 0.05) by including RMF in the Canarana grass ensilage. The RMF in the ensilage did not influence cold carcass weight and yield. The fat content of the meat decreased (P < 0.05) with the inclusion of RMF in the ensilage. It is recommended the inclusion of up to 210 g/kg of RMF in Canarana grass ensilage to increase feed efficiency and avoid impacts on the performance and carcass attributes of confined lambs.

Relationship between biochemical, environmental, and microbiological changes with the success rate of fertilization techniques.

The success rate for the evaluation of the results of techniques of Assisted Human Reproduction implies the occurrence of pregnancy with a live, healthy child. There are reports of the association between chemical and unhealthy environmental air conditions (bacteria, dust, particulates and volatile compounds) and reducing the success rate of embryo production and the occurrence of pregnancy. This paper reviews available information about the interference of biochemical, environmental and microbiological changes with the success of the assisted reproductive technique.

Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study.

OBJECTIVE: It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles. METHODS: We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m2) and overweight (BMI: 25.0-29.9kg/m2).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels. RESULTS: Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels > 5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98). CONCLUSION: Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.

OBJETIVO: O excesso de peso corporal tem sido associado como fator de risco para infertilidade. Este estudo teve como objetivo avaliar a associação de sobrepeso e anovulação entre mulheres inférteis com ciclos menstruais regulares. MéTODOS: Realizamos um estudo retrospectivo de caso-controle com mulheres com anovulação consistente em tratamento por reprodução assistida. As pacientes foram estratificadas entre aquelas com peso normal (índice de massa corporal [IMC]: 18,5­24,9 Kg/m2) e as com sobrepeso (IMC: 25,0­29,9 Kg/m2). As pacientes com síndrome do ovário policístico ou obesidade foram excluídas. Os grupos foram pareados por idade, duração da infertilidade, níveis de prolactina, hormônio folículo-estimulante (FSH), hormônio tiroestimulante (TSH), hormônio luteinizante (LH) e estradiol. RESULTADOS: O excesso de peso associou-se significativamente à anovulaçãoquando usados os critérios de anovulação da Organização Mundial de Saúde (OMS): níveis de progesterona > 5,65 ng/ml e evidência ultrassonográfica de colapso folicular (razão de chances [RC]: 2,69; IC95%: 1,04­6,98). CONCLUSãO: O IMC acima da faixa normal compromete a ovulação em mulheres inférteis não obesas com ciclos menstruais regulares.

Association of Overweight and Consistent Anovulation among Infertile Women with Regular Menstrual Cycle: A Case-control Study / Associação entre sobrepeso e anovulação consistente em mulheres inférteis com ciclo menstrual regular: Um estudo de caso-controle

Abstract Objective It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles. Methods We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m2) and overweight (BMI: 25.0- 29.9kg/m2).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels. Results Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels>5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98). Conclusion Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.

Resumo Objetivo O excesso de peso corporal tem sido associado como fator de risco para infertilidade. Este estudo teve como objetivo avaliar a associação de sobrepeso e anovulação entre mulheres inférteis com ciclos menstruais regulares. Métodos Realizamos um estudo retrospectivo de caso-controle com mulheres com anovulação consistente em tratamento por reprodução assistida. As pacientes foram estratificadas entre aquelas com peso normal (índice de massa corporal [IMC]: 18,5- 24,9 Kg/m2) e as com sobrepeso (IMC: 25,0-29,9 Kg/m2). As pacientes com síndrome do ovário policístico ou obesidade foram excluídas. Os grupos foram pareados por idade, duração da infertilidade, níveis de prolactina, hormônio folículo-estimulante (FSH), hormônio tiroestimulante (TSH), hormônio luteinizante (LH) e estradiol. Resultados O excesso de peso associou-se significativamente à anovulaçãoquando usados os critérios de anovulação da Organização Mundial de Saúde (OMS): níveis de progesterona>5,65 ng/ml e evidência ultrassonográfica de colapso folicular (razão de chances [RC]: 2,69; IC95%: 1,04-6,98). Conclusão O IMC acima da faixa normal compromete a ovulação em mulheres inférteis não obesas com ciclos menstruais regulares.

Interactive Music Therapy on Stress Level Reduction in Women Submitted to IVF/ICSI. Prospective Randomized Study.

OBJECTIVE: To identify the effects of interactive music therapy on stress levels in women undergoing high complexity infertility treatments. METHODS: Prospective randomized study involving 113 women treated in the Reproduction Human Laboratory of the Clinics Hospital of the Federal University of Goiás State, submitted to in vitro fertilization/intracytoplasmic sperm injection. We used Depression, Anxiety and Stress Scale, and Lipp's Stress Symptoms Inventory for Adults. In the Intervention Group, we used small and easy to play percussive musical instruments, a guitar, voice, and a recorder. We used interactive music therapy approach individually, applied before baseline ultrasound scan, oocyte pick-up, and embryo transfer. We analyzed the data using the R. Paired Student t-test to compare the results. RESULTS: Comparison of the stress levels by Depression, Anxiety and Stress Scale between the groups in the final moment of data retrieval resulted in 23.13 (SD±10.51; n=32) in the Control Group and 16.12 (SD±7.87; n=33) in the Intervention Group, being statistically different (p=0.004). Also in Lipp's Stress Symptoms Inventory for Adults there was a significant stress reduction in 39% of the patients in the Intervention Group compared to a reduction of 14% in the patients of the Control Group (p=0.032). In this same measurement resulted that only 3% of the Intervention Group patients versus 23% of the Control Group patients (p=0.027) were in the exhaustion stage. CONCLUSION: Interactive music therapy was effective for stress reduction in women during assisted reproduction techniques.

"Pretitude" e o Afroperspectivismo em Psicoterapia: Desafios para a Abordagem Gestáltica / "Pretitude" and Afroperspectivism in Psychotherapy: Challenges for the Gestalt Approach / "Pretitude" y Afroperspectivismo en Psicoterapia: Desafíos para el Enfoque de la Gestalt

Apresentamos a intervenção do projeto de extensão "Gestalt-Terapia, escuta e acolhimento psicológico de grupos", realizado desde 2018 por alunos extensionistas negros do Curso de Psicologia da Universidade Federal do Espírito Santo utilizando a abordagem Gestáltica. O objetivo é desenvolver a prática do acolhimento psicológico de grupos, para homens e mulheres negras, principalmente universitários. Para tanto, foram realizados 07 encontros no ano de 2018 (04 participantes) e 15 encontros no ano de 2019 (07 participantes), sendo 04 mulheres e 07 homens, com idades entre 19 e 45 anos. Os encontros aconteceram no Núcleo de Psicologia Aplicada em horário noturno. Os principais recursos terapêuticos são provenientes da expressão verbal e corporal, entretanto, músicas, vivências e atividades de colagens foram agregadas. Os resultados parciais indicaram que os encontros grupais proporcionaram cuidado e reconhecimento de si, do mundo e do outro, e melhora da autoestima na população assistida. Os participantes reconheceram muitos processos que interrompem as trocas afetivas, como resultado do racismo estrutural que a população negra brasileira vivencia. A consciência corporal e afetiva possibilitou uma reaproximação dos afetos positivos entre pessoas negras, de modo a reafirmar as características positivas dessa população. (AU)

We present the intervention of the extension project "Gestalt-Therapy, listening and psychological reception of groups", conducted since 2018 by black extension students of the Psychology Course of the Federal University of Espírito Santo using the Gestaltic approach. The objective is to develop the practice of psychological group reception for black men and women, mainly university students. To this end, 07 meetings were held in 2018 (04 participants) and 15 meetings in 2019 (07 participants), 04 women and 07 men, aged 19 to 45 years old. The meetings took place at the Center for Applied Psychology at night time. The main therapeutic resources came from verbal and body expression, however, songs, experiences and collage activities were added. The partial results indicated that the group meetings provided care and recognition of self, of the world and the other, it also improved self-esteem in the assisted population. The participants recognized many processes that interrupt affective exchanges as a result of the structural racism that the black Brazilian population experiences. Body and affective awareness made it possible to re-approach positive affections among black people in order to reaffirm the positive characteristics of this population. (AU)

Presentamos la intervención del proyecto de extensión "Terapia Gestalt, escucha y acogimiento psicológico de grupos", realizado desde 2018 por estudiantes negros extensionistas del Curso de Psicología de la Universidad Federal do Espírito Santo utilizando el enfoque Gestáltico. El objetivo es desarrollar una práctica de acogimiento psicológico de grupos, para hombres y mujeres negros, principalmente estudiantes universitarios. Para esto, fue realizado 07 encuentros en el año de 2018 (04 participantes) y 15 encuentros en el año de 2019 (07 participantes), siendo 04 mujeres y 07 hombres, con edades comprendidas entre 19 y 45 años. Los encuentros ocurrieron en el Núcleo de Psicología Aplicada en horario nocturno. Los principales recursos terapéuticos provenían de la expresión verbal y corporal, sin embargo, se agregaron la música, las experiencias y actividades de collage. Los resultados parciales indicaron que los encuentros grupales proporcionaron cuidado y reconocimiento de sí mismos, del mundo y del otro, y mejoraron la autoestima de la población asistida. Los participantes reconocieron muchos procesos que interrumpieron, destacándose los intercambios afectivos como resultado de un racismo estructural que la populación negra brasileña experimenta. La consciencia corporal y afectiva posibilitó una reaproximación de los afectos positivos entre personas negras, a modo de reafirmar las características positivas de esta populación. (AU)

Metformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice.

Oxaliplatin is a third-generation platinum drug commonly used as the first line treatment of metastatic colorectal cancer. Oxaliplatin-based anticancer regimens course with dose-limiting neurotoxicity. The pharmacological strategies used to manage such side effect are not totally effective. Metformin is an anti-diabetic drug that is described to negatively modulate painful diabetic neuropathy. Then, this study aimed to assess the effect of metformin in the oxaliplatin-induced peripheral sensory neuropathy in mice. For that purpose, Swiss male mice were injected with oxaliplatin (1, 2 or 4 mg/kg, i.v., twice a week with a total of nine injections) alone or in combination with daily administration of metformin (250 mg/kg, p.o.). Thermal and mechanical nociceptive tests were performed once a week for five weeks. Then, the animals were euthanized on day 35 post-first injection of oxaliplatin and the dorsal root ganglia were harvested for the assessment of c-Fos and ATF3 expressions. Oxaliplatin caused a nociceptive response accompanied by the increased expression of c-Fos and ATF3 in the dorsal root ganglia and spinal cord. In addition, the oxaliplatin-associated nociception was significantly attenuated by metformin (P < 0.05), which also reduced the expression of c-Fos and ATF3 (P < 0.05). Therefore, metformin protected from the peripheral sensory neuropathy induced by oxaliplatin, which was confirmed by the reduction of c-Fos and ATF3 expression, two known neuronal activation and damage markers, respectively.

Pregnancy rates from natural and artificial cycles of women submitted to frozen embryo transfers: a metanalysis.

OBJECTIVE: To compare pregnancy rates from natural and artificial cycles of women submitted to frozen embryo transfers. METHODS: A systematic review was performed by PubMed search using the following algorithm: (endometrial [All Fields] AND preparation [All Fields]) AND (("freezing"[MeSH Terms] OR "freezing"[All Fields] OR "frozen"[All Fields]) AND thawed [All Fields]) and (natural cycles) AND (artificial cycle). Inclusion criteria: prospective and retrospective cohort studies. Exclusion criteria: use of hCG in the natural cycle, oocyte donors, and use of disused freezing techniques. Data were analyzed with the SPSS v.23 software and with a significance level of 5%. The meta-analysis was performed with RevMan 5.3 software. I² was calculated. RESULTS: 709 papers were retrieved. Five studies fulfilled the inclusion and exclusion criteria. From these studies, we analyzed 8,968 natural or artificial cycles. A contingency table compared the results of the natural and artificial cycles and the number of clinical pregnancies obtained in each selected paper. The I2 test resulted in high statistical heterogeneity (I2=77%). Studies by Morozov et al. (2007) and Zheng et al. (2015) obtained statistically significant results (p<0.03 and p<0.001): Morozov et al. (2007) found a higher pregnancy rate within natural cycles, and Zheng et al. (2015) found more positive outcomes when analyzing artificial cycles. The remaining selected studies did not show any statistical significance. CONCLUSION: There is insufficient scientific evidence to state that the artificial cycle yields better pregnancy rates than the natural cycle in women submitted to frozen embryo transfer. Limitations of this study include a small number of papers and heterogeneity among the studies.

Effect of the Air Filtration System Replacement on Embryo Quality in the Assisted Reproduction Laboratory.

Improving infrastructural conditions of the in vitro fertilization laboratory, such as the air quality, has profound positive effects on embryo culture. Poor environmental conditions reduce the rate of embryo formation and, therefore, of pregnancy. This review article presents important publications regarding the impact of air quality in human reproduction laboratories on embryo quality, pregnancy success, and live births. The studies demonstrate that the replacing the air filtration system improves significantly the environmental air quality, and, consequently, improves laboratory parameters, such as the fertilization rate, the number of blastocysts, the embryo implantation rate, and the number of live births. On the other hand, improving air quality decreases the number of abortions. Therefore, environmental parameters that improve embryo quality and increase healthy child birth rates must be the main targets for the assisted reproduction laboratory quality control.

Melhorar as condições de infraestrutura do laboratório de fertilização in vitro, com influência na qualidade do ar, tem efeitos positivos profundos na qualidade do embrião. As más condições ambientais do ar reduzem a taxa de sucesso na formação de embriões e a taxa de gravidez. Este artigo de revisão apresenta importantes publicações sobre o impacto da qualidade do ar dentro do laboratório de reprodução humana na qualidade do embrião, no sucesso de gravidez e no número de nascidos vivos. Os estudos demonstram que a troca do sistema de filtração de ar melhora significativamente a qualidade do ar ambiente, e consequentemente, melhora os parâmetros laboratoriais, tais como a taxa de fertilização, o número de blastocistos, a taxa de implantação e o número de nascidos vivos. Por outro lado, a melhora da qualidade do ar diminui o número de abortos. Portanto, os parâmetros ambientais que melhoram a qualidade do embrião e aumentam as taxas de nascimentos de crianças saudáveis devem ser os principais alvos para o controle de qualidade do laboratório de reprodução assistida.

Effect of the air filtration system replacement on embryo quality in the assisted reproduction laboratory / Efeito da troca do sistema de filtragem do ar na qualidade embrionária no laboratório de reprodução assistida

Abstract Improving infrastructural conditions of the in vitro fertilization laboratory, such as the air quality, has profound positive effects on embryo culture. Poor environmental conditions reduce the rate of embryo formation and, therefore, of pregnancy. This review article presents important publications regarding the impact of air quality in human reproduction laboratories on embryo quality, pregnancy success, and live births. The studies demonstrate that the replacing the air filtration system improves significantly the environmental air quality, and, consequently, improves laboratory parameters, such as the fertilization rate, the number of blastocysts, the embryo implantation rate, and the number of live births. On the other hand, improving air quality decreases the number of abortions. Therefore, environmental parameters that improve embryo quality and increase healthy child birth ratesmust be themain targets for the assisted reproduction laboratory quality control.

Resumo Melhorar as condições de infraestrutura do laboratório de fertilização in vitro, com influência na qualidade do ar, tem efeitos positivos profundos na qualidade do embrião. As más condições ambientais do ar reduzem a taxa de sucesso na formação de embriões e a taxa de gravidez. Este artigo de revisão apresenta importantes publicações sobre o impacto da qualidade do ar dentro do laboratório de reprodução humana na qualidade do embrião, no sucesso de gravidez e no número de nascidos vivos. Os estudos demonstram que a troca do sistema de filtração de ar melhora significativamente a qualidade do ar ambiente, e consequentemente, melhora os parâmetros laboratoriais, tais como a taxa de fertilização, o número de blastocistos, a taxa de implantação e o número de nascidos vivos. Por outro lado,amelhora da qualidade do ar diminui o número de abortos. Portanto, os parâmetros ambientais que melhoram a qualidade do embrião e aumentam as taxas de nascimentos de crianças saudáveis devem ser os principais alvos para o controle de qualidade do laboratório de reprodução assistida.

Alpha band EEG coherence in healthy nonagenarians.

OBJECTIVE: Electroencephalographic (EEG) coherence is a parameter that enables evaluation of cerebral connectivity. It may be related to the functional state of the brain. In the elderly, it may reflect the neuronal loss caused by aging. To describe characteristics of coherence in nonagenarians. METHODS: We evaluated interhemispheric coherence for the alpha band in 42 cognitively normal individuals aged 90 to 101 years. Coherence values in the occipital electrode (O1O2), in the resting state with closed eyes, were calculated by means of spectral analysis using digital EEG EMSA 32 channels, 12 bits and a frequency of 200 Hz. RESULTS: The mean coherence value for the alpha band at O1O2 was 0.65 (SD 0.13). No significant differences were found between men and women. CONCLUSIONS: The findings from this study did not show any decrease in interhemispheric coherence for the alpha band in cognitively normal nonagenarians. This may be useful as a standard value for this age group.

Alpha band EEG coherence in healthy nonagenarians / Coerência da banda alfa do EEG em nonagenários saudáveis

ABSTRACT Electroencephalographic (EEG) coherence is a parameter that enables evaluation of cerebral connectivity. It may be related to the functional state of the brain. In the elderly, it may reflect the neuronal loss caused by aging. Objective To describe characteristics of coherence in nonagenarians. Methods We evaluated interhemispheric coherence for the alpha band in 42 cognitively normal individuals aged 90 to 101 years. Coherence values in the occipital electrode (O1O2), in the resting state with closed eyes, were calculated by means of spectral analysis using digital EEG EMSA 32 channels, 12 bits and a frequency of 200 Hz. Results The mean coherence value for the alpha band at O1O2 was 0.65 (SD 0.13). No significant differences were found between men and women. Conclusions The findings from this study did not show any decrease in interhemispheric coherence for the alpha band in cognitively normal nonagenarians. This may be useful as a standard value for this age group.

RESUMO A coerência é um parâmetro que permite avaliar a conectividade cerebral, podendo se relacionar com o estado funcional do cérebro. Especialmente nos idosos, pode refletir a perda neuronal decorrente do envelhecimento. Objetivo Descrever características da coerência em nonagenários. Métodos Avaliamos a coerência interhemisferica para a banda alfa em 42 indivíduos cognitivamente normais entre 90 e 101 anos. Foram calculados através da análise espectral o valor da coerência nos eletrodos O1O2, em estado de repouso e olhos fechados, com EEG digital 32 canais marca EMSA 12 bits e frequência de amostragem 200 hz. Resultados O valor médio da coerência para a banda alfa entre O1O2 foi de 0,65 (DP 0,13). Não encontramos diferenças significativas entre homens e mulheres. Conclusão Os achados desse estudo não evidenciam diminuição da coerência interhemisferica para a banda alfa nos eletrodos O1O2 em nonagenários saudáveis e cognitivamente normais, podendo indicar um valor padrão para essa faixa etária.

Epidemiological profile of patients with traumatic spinal fracture / Perfil epidemiológico dos pacientes com fratura traumática de coluna vertebral / Perfil epidemiológico de los pacientes con fractura traumática de la columna vertebral

ABSTRACT Objective: To analyze the epidemiological profile of patients with spinal fractures and the characteristics of the population at risk attended at a university hospital. Methods: The study population is composed of 202 patients diagnosed and treated for vertebral fracture due to trauma. The variables were correlated with each other and the correlations with p<0.05 were considered statistically significant. Results: The ratio of incidence of trauma between the sexes was 3:1 for males. The mean age was 37 years and the age group with the highest incidence was between 20 and 39 years. Traffic accidents were the most frequent mechanism (51.2%) and secondly, falls (33.2%). There was a statistical correlation between trauma mechanisms to age group and region of the spine. The first lumbar vertebra (L1) fracture alone accounted for 21.5% of all cases studied associated with the fall mechanism. Spinal cord injury was recorded in 33.7% of the individuals in the sample. A total of 57.3% of the patients were submitted to surgical treatment and 41.7% to the conservative treatment. The mean hospitalization time was 15 days. Conclusions: Spinal fractures are important determinants of morbidity and mortality in the population with a major impact on economically active individuals, especially males. They are directly associated to traffic accidents in the young population and to falls in the higher age brackets. Primary prevention of trauma is the main mechanism for change in this scenario.

RESUMO Objetivo: Analisar o perfil epidemiológico dos pacientes com fratura da coluna vertebral e as características da população de risco atendida em um hospital universitário. Métodos: A população do estudo é composta de 202 pacientes diagnosticados e tratados por fratura de vértebras devido a trauma. As variáveis foram correlacionadas entre si e consideradas estatisticamente significantes as correlações com p < 0,05. Resultados: A relação da incidência do trauma entre os sexos foi 3:1 para o sexo masculino. A média de idade foi 37 anos e a faixa etária de maior incidência entre 20 e 39 anos. Os acidentes de trânsito foram o mecanismo de mais frequente (51,2%) e em segundo lugar, as quedas (33,2%). Houve correlação estatística dos mecanismos de trauma conforme faixa etária e região da coluna vertebral. A fratura de primeira vértebra lombar (L1) representou sozinha 21,5% de todos os casos estudados associados ao mecanismo queda. A lesão raquimedular foi registrada em 33,7% dos indivíduos da amostra. Um total de 57,3% dos pacientes foi submetido a tratamento cirúrgico e 41,7% ao conservador. O tempo de internação médio foi de 15 dias. Conclusões: As fraturas de coluna são importantes determinantes de morbidade e mortalidade da população, com impacto principal nos indivíduos economicamente ativos, sobretudo do sexo masculino. Estão diretamente associadas a acidentes de trânsito na população jovem e a quedas nas faixas etárias maiores. A prevenção primária do trauma é o principal mecanismo para mudança desse cenário.

RESUMEN Objetivo: Analizar el perfil epidemiológico de los pacientes con fractura de la columna vertebral y las características de la población de riesgo tratada en un hospital universitario. Métodos: La población del estudio está compuesta de 202 pacientes diagnosticados y tratados por fractura de vértebras debido a trauma. Las variables se correlacionaron entre sí y se consideraron estadísticamente significativas las correlaciones comp < 0,05. Resultados: La proporción de incidencia del trauma entre los sexos fue 3:1 para el sexo masculino. La edad media fue de 37 años y el rango de edad de mayor incidencia fue entre 20 y 39 años. Los accidentes de tránsito fueron el mecanismo más frecuente (51,2%) y en segundo lugar, las caídas (33,2%). Se observó correlación estadística entre los mecanismos de trauma según el grupo de edad y la región de la columna vertebral. La fractura de la primera vértebra lumbar (L1) sola representó el 21,5% de todos los casos estudiados asociados al mecanismo de caída. La lesión de la médula espinal se registró en el 33,7% de los individuos de la muestra. Un total de 57,3% de los pacientes fueron sometidos a tratamiento quirúrgico y el 41,7% al conservador. La duración promedio de la estancia hospitalaria fue de 15 días. Conclusiones: Las fracturas de columna son determinantes importantes de morbilidad y mortalidad con impacto principal en los individuos económicamente activos, sobre todo del sexo masculino. Se asocian directamente con los accidentes de tránsito en la población joven y a las caídas en los rangos de edad mayores. La prevención primaria del trauma es el principal mecanismo para cambiar este escenario.

Ficha Digital: Avaliação de Solução Tecnológica Aplicada na Saúde Pública / Digital Paper: Evaluation of Applied Technology in Public Health System / Ficha Digital: Evaluación dSolución Tecnológica Aplicada en Salud Publica

Objetivo: Avaliar um sistema de informação implantado na rede pública de saúde em São Paulo para registrar e armazenar dados de pacientes, digitalizando em tempo real a escrita à mão da equipe assistencial durante o atendimento quanto a sua efetividade nas rotinas do processo de trabalho. Métodos: Estudo exploratório e descritivo sobre o sistema "ficha digital" com pesquisa aplicada e revisão da literatura. Resultados: 1.211 profissionais de saúde: gerentes, enfermeiros e médicos, participaram de pesquisa qualitativa com perguntas objetivas sobre a ferramenta e 145 responderam. As respostas possibilitaram tecer uma avaliação sobre a efetividade do sistema e a revisão da literatura destacou o interesse crescente por essa ferramenta. Conclusão: É um sistema que disponibiliza tecnologia inovadora e diferenciada como está em operação e seu potencial não é plenamente utilizado, requerendo desenvolvimento contínuo e interativo para aumentar sua efetividade.

Objective: The aim of this study was to evaluate the information system deployed in public health network in São Paulo such as his effectiveness in the routines of the work process through the results of search and a review of literature. Methods: Exploratory and descriptive study of "digital paper" that provides the resources to record and store patient data by scanning a handwritten of the health care professional during the assistance. Results: 1,211 health care professionals in three categories, managers, nurses and physicians, were invited and participated in qualitative research and 145 answered. The answers made it to weave the effectiveness of the "digital paper" and the literature review confirmed the growing interest of this tool. Conclusion: The conclusion was that the system offers innovative and advanced technology such as in operation and it's not fully utilized on his high potential, requiring continuous and interactive development to increase its effectiveness.

Objetivo: Evaluar un sistema de información desplegada en la red de salud pública en São Paulo por su eficacia en las rutinas del proceso de trabajo a través de los resultados de una encuesta y revisión de la literatura. Métodos: Estudio exploratorio y descriptivo del sistema "ficha digital" que se utiliza para registrar y almacenar datos de los pacientes mediante el escaneo de un escrito a mano el equipo de atención durante el servicio. Resultados: 1.211 profesionales de la salud: gerentes, enfermeras y médicos, participaron en la investigación cualitativa con preguntas objetivas sobre la herramienta y 145 respondieron. Las respuestas han permitido tejer una evaluación de la eficacia del sistema y de la revisión de la literatura confirman el creciente interés en esta herramienta. Conclusión: Es un sistema que ofrece la innovadora tecnología, diferenciada, ya que se encuentra en funcionamiento y su potencial no se utiliza por completo, lo que requiere el desarrollo continuo e iterativo con la finalidad de aumentar su eficacia.

Há alteração do dia da ovulação em pacientes com sobrepeso ou obesidade? Estudo transversal / Are there change in ovulation day in patients with overweight or obesity? Cross­sectional study

Introdução: A função primordial do ciclo menstrual é promover a capacidade reprodutiva da mulher e alterações nesse ciclo impactam na fertilidade feminina. A obesidade é frequentemente associada a alterações do ciclo menstrual. Objetivo: Avaliar se existe diferença do dia da ovulação entre pacientes com índice de massa corpórea (IMC) normal e aquelas com sobrepeso ou obesidade em pacientes inférteis que não apresentam síndrome de ovários policísticos. Métodos: Estudo transversal feito em ambulatório de reprodução humana. Foram avaliados dois grupos, um com 71 pacientes com IMC normal e outro de 45 pacientes com IMC que indicava sobrepeso/obesidade. Foi analisado a seguir o dia da ovulação das pacientes de cada grupo. As amostras incluíram pacientes de 18 a 38 anos, sem síndrome de ovários policísticos, com as variáveis que pudessem interferir na ovulação pareadas, o que garantia a homogeneidade dos grupos. Resultados: As pacientes com sobrepeso ou obesidade tiveram a ovulação em média no 14,62◦ dia do ciclo e as pacientes com IMC normal em média no 14, 21◦ dia. Não houve significância estatística entre os grupos. Conclusão: Não houve diferença estatística do dia da ovulação entre as pacientes com IMC normal e aquelas com sobrepeso ou obesidade, que não apresentavam outras comorbidades que pusessem afetar a fertilidade.(AU)

Background: The primary function of the menstrual cycle is to promote the reproductive capacity of women and changes in this cycle impact on female fertility. Obesity is often associated with changes in the menstrual cycle. Objective: Assess whether there is difference between ovulation's day in patients with normal BMI and those with overweight or obesity in infertile patients without Polycystic Ovary Syndrome. Methods: Cross-sectional study in Human Reproduction Outpatient Clinic. Two groups, one with 71 patients with normal BMI and the other with 45 patients with a BMI indicating overweight/obesity. It was next analyzed the day of ovulation of patients in each group. The samples included patients 18-38 years without Polycystic Ovary Syndrome, whith the variables that could interfere with ovulation, matched, ensuring the homogeneity of the groups. Results: Patients with overweight or obese had an average ovulation in 14.62◦ day of the cycle, and patients with normal BMI average at 14.21◦ day, with no statistical significance between groups. Conclusion: there was no statistical difference of day of ovulation among patients with normal BMI and those with overweight or obesity, which had no other comorbidities that would put affect fertility.

[Chlamydia trachomatis and Neisseria gonorrhoeae infection: factors associated with infertility in women treated at a human reproduction public service]. / Infecção por Chlamydia trachomatis e Neisseria gonorrhoeae: fatores associados à infertilidade em mulheres atendidas em um serviço público de reprodução humana.

PURPOSE: To evaluate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in women undergoing assisted reproduction in a public reference service in the midwestern region of Brazil. METHODS: A cross-sectional study was conducted on 340 women aged from 20 to 47 years with a history of infertility, undergoing assisted reproduction techniques. Infections with Chlamydia trachomatis and Neisseria gonorrhoeae identified in urine specimens by PCR, and the profile of infertility were analyzed. We used the χ(2) test or Fisher's exact test to evaluate the association between infection and variables. RESULTS: The prevalence of Chlamydia trachomatis infection was 10.9%, and Neisseria gonorrhoeae co-infection was observed in 2 cases. Women infected with Chlamydia trachomatis had more than 10 years of infertility (54.1%; p<0.0001). The tubal factor was the main cause in infected cases (56.8%; p=0.047). Tubal occlusion was found in 67.6% of cases with positive infection (p=0.004). CONCLUSION: There was an association of tubal obstruction with infection by Chlamydia trachomatis and Neisseria gonorrhoeae, reinforcing the need for effective strategies for an early detection of sexually transmitted diseases, especially in asymptomatic women of childbearing age.

Infecção por Chlamydia trachomatis e Neisseria gonorrhoeae: fatores associados à infertilidade em mulheres atendidas em um serviço público de reprodução humana / Chlamydia trachomatis and Neisseria gonorrhoeae infection: factors associated with infertility in women treated at a human reproduction public service

OBJETIVO: Avaliar a prevalência de infecção por Chlamydia trachomatis e Neisseria gonorrhoeae em mulheres submetidas à reprodução assistida em um serviço público de referência da região Centro-Oeste do Brasil. MÉTODOS: Estudo transversal com 340 mulheres com idade entre 20 e 47 anos, histórico de infertilidade, submetidas às técnicas de reprodução assistida. Foram analisadas as infecções por Chlamydia trachomatis e Neisseria gonorrhoeae detectadas em amostras de urina pela técnica de PCR e o perfil da infertilidade. Utilizou-se o teste do χ2 ou o teste exato de Fisher para avaliar a associação entre a infecção e as variáveis. RESULTADOS: Observou-se prevalência de 10,9% das mulheres com infecção por Chlamydia trachomatis, sendo que houve coinfecção por Neisseria gonorrhoeae em 2 casos. Mulheres infectadas por Chlamydia trachomatis apresentaram mais de 10 anos de infertilidade (54,1%; p<0,0001). O fator tubário foi a principal causa nos casos com infecção (56,8%; p=0,047). A obstrução tubária foi encontrada em 67,6% dos casos com infecção positiva (p=0,004). CONCLUSÃO: Houve associação da obstrução tubária com a infecção por Chlamydia trachomatis e Neisseria gonorrhoeae, reforçando a necessidade de estratégias efetivas para detecção precoce das doenças sexualmente transmissíveis, principalmente em mulheres assintomáticas em idade fértil. .

PURPOSE: To evaluate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in women undergoing assisted reproduction in a public reference service in the midwestern region of Brazil. METHODS: A cross-sectional study was conducted on 340 women aged from 20 to 47 years with a history of infertility, undergoing assisted reproduction techniques. Infections with Chlamydia trachomatis and Neisseria gonorrhoeae identified in urine specimens by PCR, and the profile of infertility were analyzed. We used the χ2 test or Fisher's exact test to evaluate the association between infection and variables. RESULTS: The prevalence of Chlamydia trachomatis infection was 10.9%, and Neisseria gonorrhoeae co-infection was observed in 2 cases. Women infected with Chlamydia trachomatis had more than 10 years of infertility (54.1%; p<0.0001). The tubal factor was the main cause in infected cases (56.8%; p=0.047). Tubal occlusion was found in 67.6% of cases with positive infection (p=0.004). CONCLUSION: There was an association of tubal obstruction with infection by Chlamydia trachomatis and Neisseria gonorrhoeae, reinforcing the need for effective strategies for an early detection of sexually transmitted diseases, especially in asymptomatic women of childbearing age. .

Influence of Plasmodium vivax malaria on the relations between the osmotic stability of human erythrocyte membrane and hematological and biochemical variables.

This study evaluated the influence of infection by Plasmodium vivax on the relations between hematological and biochemical variables and the osmotic stability of the erythrocyte membrane in a Brazilian Amazon population. A total of 72 patients with P. vivax malaria were included in the study and invited to return after 14 days, post-treatment with chloroquine and primaquine, for clinical and laboratorial reevaluations. The osmotic stability of the erythrocyte membrane was analyzed by nonlinear regression of the dependency of the absorbance of hemoglobin, released with hemolysis, as a function of the salt concentration, and it was represented by the inverse of the salt concentration at the midpoint of the curve (1/H 50) and by the variation of salt concentration, which promotes lysis (dX). Bivariate and multivariate methods were used in the analysis of the results. Prior to treatment of the disease, the erythrocytes showed greater stability, probably due to the natural selection of young and also more stable erythrocytes. The bivariate analysis showed that 1/H 50 was positively correlated with red cell distribution width (RDW), urea, triglycerides, and very low-density lipoprotein (VLDL)-cholesterol, but negatively associated with albumin, HDL-cholesterol, and indirect bilirubin, while dX was negatively associated with the mean corpuscular hemoglobin concentration. These associations were confirmed by canonical correlation analysis. Stepwise multiple linear regression showed that albumin, urea, triglycerides, and VLDL-cholesterol are the variables with the highest abilities of predicting erythrocyte stability. The bivariate analysis also showed that the hematological index RDW was related to elevated levels of bilirubin and decreased levels of albumin and urea, associated with liver damage resulting from malaria.