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Antibiotiki ; 27(12): 51-3, 1982 Dec.
Article in Russian | MEDLINE | ID: mdl-7165295

ABSTRACT

The pharmacokinetics of ampicillin was studied in 30 children with diseases of the upper respiratory tracts. The data obtained with a single administration of anhydrous ampicillin in a dose of 25 mg/kg were estimated on one-compartment model. It was shown that the maximum antibiotic levels in the serum were attained in 1.52 hours and averaged to 4.56 micrograms/ml. The antibiotic half-life was 1.24 hours. The period of half-absorption of the antibiotic was 0.66 hours. Comparison of the experimental results with the literature data showed that the pharmacokinetic properties of anhydrous ampicillin and ampicillin trihydrate were close.


Subject(s)
Ampicillin/metabolism , Respiratory Tract Infections/drug therapy , Ampicillin/therapeutic use , Biological Availability , Child , Child, Preschool , Half-Life , Humans , Kinetics , Time Factors
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