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2.
Front Robot AI ; 10: 1137750, 2023.
Article in English | MEDLINE | ID: mdl-37064575

ABSTRACT

Surveying active nuclear facilities for spread of alpha and beta contamination is currently performed by human operators. However, a skills gap of qualified workers is emerging and is set to worsen in the near future due to under recruitment, retirement and increased demand. This paper presents an autonomous ground vehicle that can survey nuclear facilities for alpha, beta and gamma radiation and generate radiation heatmaps. New methods for preventing the robot from spreading radioactive contamination using a state-machine and radiation costmaps are introduced. This is the first robot that can detect alpha and beta contamination and autonomously re-plan around the contamination without the wheels passing over the contaminated area. Radiation avoidance functionality is proven experimentally to reduce alpha and beta contamination spread as well as gamma radiation dose to the robot. The robot's survey area is defined using a custom designed, graphically controlled area coverage planner. It was concluded that the robot is highly suited to certain monotonous room scale radiation surveying tasks and therefore provides the opportunity for financial savings, to mitigate a future skills gap, and provision of radiation surveys that are more granular, accurate and repeatable than those currently performed by human operators.

3.
ISA Trans ; 53(2): 584-90, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24434124

ABSTRACT

Batch processes are commonly characterized by uneven trajectories due to the existence of batch-to-batch variations. The batch end-product quality is usually measured at the end of these uneven trajectories. It is necessary to align the time differences for both the measured trajectories and the batch end-product quality in order to implement statistical process monitoring and control schemes. Apart from synchronizing trajectories with variable lengths using an indicator variable or dynamic time warping, this paper proposes a novel approach to align uneven batch data by identifying short-window PCA&PLS models at first and then applying these identified models to extend shorter trajectories and predict future batch end-product quality. Furthermore, uneven batch data can also be aligned to be a specified batch length using moving window estimation. The proposed approach and its application to the control of batch end-product quality are demonstrated with a simulated example of fed-batch fermentation for penicillin production.


Subject(s)
Drug Industry/instrumentation , Algorithms , Biomass , Bioreactors , Chemistry, Pharmaceutical/instrumentation , Fermentation , Oxygen/chemistry , Penicillins/chemistry , Quality Control
4.
Appl Spectrosc ; 66(3): 272-81, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22449303

ABSTRACT

This paper describes the application of principal component analysis (PCA) and independent component analysis (ICA) to identify the reference spectra of a pharmaceutical tablet's constituent compounds from Raman spectroscopic data. The analysis shows, first with a simulated data set and then with data collected from a pharmaceutical tablet, that both PCA and ICA are able to identify most of the features present in the reference spectra of the constituent compounds. However, the results suggest that the ICA method may be more appropriate when attempting to identify unknown reference spectra from a sample. The resulting PCA and ICA models are subsequently used to estimate the relative concentrations of the constituent compounds and to produce spatial distribution images of the analyzed tablet. These images provide a visual representation of the spatial distribution of the constituent compounds throughout the tablet. Images associated with the ICA scores are found to be more informative and not as affected by measurement noise as the PCA based score images. The paper concludes with a discussion of the future work that needs to be undertaken for ICA to gain wider acceptance in the applied spectroscopy community.


Subject(s)
Chemistry, Pharmaceutical/methods , Spectrum Analysis, Raman/methods , Tablets/chemistry , Multivariate Analysis , Principal Component Analysis
5.
Appl Spectrosc ; 63(10): 1142-51, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19843365

ABSTRACT

Frequency displacement, or spectral shift, is commonly observed in industrial spectral measurements. It can be caused by many factors such as sensor de-calibration or by external influences, which include changes in temperature. The presence of frequency displacement in spectral measurements can cause difficulties when statistical techniques, such as independent component analysis (ICA), are used to analyze it. Using simulated spectral measurements, this paper initially highlights the effect that frequency displacement has on ICA. A post-processing technique, employing particle swarm optimization (PSO), is then proposed that enables ICA to become robust to frequency displacement in spectral measurements. The capabilities of the proposed approach are illustrated using several simulated examples and using tablet data from a pharmaceutical application.


Subject(s)
Algorithms , Data Interpretation, Statistical , Models, Theoretical , Citalopram/chemistry , Computer Simulation , Databases, Factual , Pharmaceutical Preparations/chemistry , Spectroscopy, Near-Infrared
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