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Background/Aims@#Nonalcoholic fatty liver disease (NAFLD) is closely associated with diabetes. The cumulative impact of both diseases synergistically increases risk of adverse events. However, present population analysis is predominantly conducted with reference to non-NAFLD individuals and has not yet examined the impact of prediabetes. Hence, we sought to conduct a retrospective analysis on the impact of diabetic status in NAFLD patients, referencing non-diabetic NAFLD individuals. @*Methods@#Data from the National Health and Nutrition Examination Survey 1999–2018 was used. Hepatic steatosis was defined with United States Fatty Liver Index (US-FLI) and FLI at a cut-off of 30 and 60 respectively, in absence of substantial alcohol use. A multivariate generalized linear model was used for risk ratios of binary outcomes while survival analysis was conducted with Cox regression and Fine Gray model for competing risk. @*Results@#Of 32,234 patients, 28.92% were identified to have NAFLD. 36.04%, 38.32% and 25.63% were non-diabetic, prediabetic and diabetic respectively. Diabetic NAFLD significantly increased risk of cardiovascular disease (CVD), stroke, chronic kidney disease, all-cause and CVD mortality compared to non-diabetic NAFLD. However, prediabetic NAFLD only significantly increased the risk of CVD and did not result in a higher risk of mortality. @*Conclusions@#Given the increased risk of adverse outcomes, this study highlights the importance of regular diabetes screening in NAFLD and adoption of prompt lifestyle modifications to reduce disease progression. Facing high cardiovascular burden, prediabetic and diabetic NAFLD individuals can benefit from early cardiovascular referrals to reduce risk of CVD events and mortality.
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INTRODUCTION@#We developed a Clinical Frailty Scale algorithm (CFS-A) to minimise inter-rater variability and to facilitate wider application across clinical settings. We compared the agreement, diagnostic performance and predictive utility of CFS-A against standard CFS.@*MATERIALS AND METHODS@#We retrospectively analysed data of 210 hospitalised older adults (mean age, 89.4 years). Two independent raters assessed frailty using CFS-A. Agreement between CFS-A raters and with previously completed CFS was determined using Cohen's Kappa. Area under receiver operator characteristic curves (AUC) for both measures were compared against the Frailty Index (FI). Independent associations between these measures and adverse outcomes were examined using logistic regression.@*RESULTS@#Frailty prevalence were 81% in CFS and 96% in CFS-A. Inter-rater agreement between CFS-A raters was excellent (kappa 0.90, <0.001) and there was moderate agreement between CFS-A and standard CFS (kappa 0.42, <0.001). We found no difference in AUC against FI between CFS (0.91; 95% CI, 0.86-0.95) and CFS-A (0.89; 95% CI, 0.84-0.95; <0.001). Both CFS (OR, 3.59; 95% CI, 2.28-5.67; <0.001) and CFS-A (OR, 4.31; 95% CI, 2.41-7.69; <0.001) were good predictors of mortality at 12 months. Similarly, CFS (OR, 2.59; 95% CI, 1.81-3.69; <0.001) and CFS-A (OR, 3.58; 95% CI, 2.13-6.02; <0.001) were also good predictors of institutionalisation and/or mortality after adjusting for age, sex and illness severity.@*CONCLUSION@#Our study corroborated the results on inter-rater reliability, diagnostic performance and predictive validity of CFS-A which has the potential for consistent and efficient administration of CFS in acute care settings.
ABSTRACT
New experiments reveal that the relative growth between cell surface area and volume are key determinants of the shape and size of rod-like bacteria. These results are synthesized into a relative-growth model that applies to questions ranging from morphogenesis to cell-cycle timing.
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Cell Size , Cell Wall , Bacteria , Cell Division , MorphogenesisABSTRACT
The purpose of this study was to evaluate the construct and content validity of the Neck Disability Index (NDI) and the Neck Pain and Disability Scale (NPAD) in patients with chronic, non-traumatic neck pain. Twenty patients (mean age=64.5 years) completed a patient-specific questionnaire, the Problem Elicitation Technique (PET), followed by the NDI and NPAD. Content validity was assessed by comparing the items of the NDI and NPAD with problems identified from the PET. Construct validity of the fixed-item questionnaires was examined by establishing the correlation with each other, and with the PET score. Eleven common problems were identified by patients through the PET, of which six were included in the NDI and seven included in the NPAD. The NDI and NPAD scores were strongly correlated (r=0.86, p<0.01), while the correlation between the PET and the fixed-item questionnaires was moderate (NDI: r=0.62, p<0.01; NPAD: r=0.71, p<0.01). Both the NDI and the NPAD include most of the functional problems common to this patient group, and display good content validity. The PET is better able to evaluate the problems specific to the individual patient and is therefore measuring a somewhat different construct to the fixed-item questionnaires.
