The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck.

Background: Delays in starting postoperative radiotherapy (PORT) have been established as negative predictors for clinical outcomes in head and neck squamous cell carcinomas (HNSCC). Our study aimed to examine the effect of delays during PORT, and the impact of national holidays in Canada, a publicly funded system, on oncologic outcomes such as Overall Survival (OS) and Local Recurrence (LR). Methods: The provincial cancer registry was queried to obtain demographic, pathologic, and outcomes data from cancer patients treated for all squamous cell carcinomas of the head and neck region treated between January 1, 2007 and November 30, 2019. All extracted information was cross-referenced and supplemented by chart review of patient electronic medical records. Extracted data were analyzed for OS and LR, in the context of Canadian national holidays causing delays during PORT. Results: 1433 patients treated for HNSCCs were identified, of whom 338 were treated curatively with surgery followed by PORT. 68.6% of patients experienced at least one day of interruption during treatments due to holidays. LR was 15.4% and OS was 59.6% at 5 years. Treatment interruptions by holidays were predictive of local recurrence (HR, 2.38; 95% CI 1.17-4.83; p = 0.017). Patients that developed early recurrence prior to PORT had very poor oncologic outcomes. Conclusion: Our findings were consistent with previously published studies in limiting the interval between surgery and PORT. We identified the novel finding of paired holidays as a significant predictor in determining LR, suggesting the importance of modifying RT delivery schedules and timing.

Tracheostomy versus mandibular distraction osteogenesis in Canadian children with Pierre Robin sequence: a comparative cost analysis.

INTRODUCTION: Upper airway obstruction in newborns with Pierre Robin sequence (PRS) may be severe enough to require a surgical intervention. Tracheostomy has been the traditional gold standard, but mandibular distraction osteogenesis (MDO) has been proven to be an effective alternative procedure. OBJECTIVE: The objective of the present study was to conduct the first comparative cost analysis between tracheostomy and MDO in Canada. METHODS: All patients with PRS who underwent tracheostomy or MDO between January 2005 and December 2010 were included. Tracheostomy and MDO procedures were broken down into individual components, and the associated costs for these components were totaled. The average per-patient cost for each modality was then compared. RESULTS: During the study period, 52 children underwent either a tracheostomy (n  =  31) or MDO (n  =  21). The average age at surgery, gender, and presence of associated syndromes were similar in both groups. Taking into account the cost of the surgeries, health care professional fees, and hospital stay, the total per-patient treatment cost was determined to be $57,648.55 for MDO and $92,164.45 for tracheostomy. The majority of the cost for the tracheostomy group was associated with prolonged hospital stay after the operation ($72,827.85). Overall, the average per-patient cost was 1.6 times greater in the tracheostomy group compared to the MDO group (p  =  .039). CONCLUSION: The initial cost of MDO was less than the tracheostomy cost for newborns with PRS and severe upper airway obstruction at our health care centre. Further prospective analysis considering the long-term costs is required to possibly reduce long-term health care costs.

T2 glottic carcinoma: analysis of recurrences in 36 cases undergoing primary transoral laser microsurgery resection.

OBJECTIVE: Between 2002 and 2008, over 100 patients with glottic carcinoma have undergone transoral laser microsurgical (TLM) resection at the QEII Health Sciences Centre in Halifax, Nova Scotia. The objective of this study was to assess the oncologic outcomes for all cases staged as T2 in this cohort. METHODS: A prospective database was developed to monitor outcomes. All 36 cases of primary T2 glottic carcinoma were selected from the database for analysis. Kaplan-Meier survival analyses evaluated the following end points at 36 months: overall survival, disease-specific survival, and local control and disease-free survival with one procedure. RESULTS: The Kaplan-Meier estimates of 36-month outcomes were 89% (SE 6.0%) overall survival and disease-specific survival, 81% (SE 7.1%) local control with one procedure, and 70% (SE 8.0%) disease-free survival with one procedure. CONCLUSIONS: The observed 36-month outcomes support the use of TLM as the primary treatment modality for T2 glottic cancers.

Oncologic and voice outcomes after treatment of early glottic cancer: transoral laser microsurgery versus radiotherapy.

OBJECTIVE: To compare the laryngeal preservation rates and voice outcomes after treatment of early glottic cancer between transoral laser microsurgery (TLM) and radiotherapy (RT). DESIGN: Multicenter, retrospective consecutive cohort of stage 1 and 2 glottic carcinoma treated with TLM or RT. SETTING: Three Canadian academic cancer centres. METHODS AND MAIN OUTCOME MEASURES: The patients were those of the regional cancer registries associated with each of the participating universities between 2002 and 2010. The primary oncologic end point was organ preservation. The primary functional outcome measure was the Voice Handicap Index (VHI-10). RESULTS: A total of 234 patients were treated for early glottic cancer (143 TLM, 91 RT). At 2 years, the laryngeal preservation rate for stage 1 disease was 100% TLM and 92% RT (p < .004); for stage 2 disease, it was 100% TLM and 88% RT (p  =  not significant). There was only one laryngectomy in the TLM group over 5 years posttreatment. There were functional data on 132 patients (83 TLM, 49 RT). Median VHI-10 scores were inferior for laser patients at all three time intervals (6, 12, and 24-48 months posttreament) despite a stage bias in favour of TLM (range of median VHI score over time intervals: TLM  =  9.5-12, RT  =  3.5-8; p  =  .01-.08). However, theses scores represent mild disability in both groups. CONCLUSIONS: TLM patients have poorer voice quality than RT patients. However, the advantages of TLM in most patients outweigh the degree of voice handicap. Organ preservation rates for TLM were better than or equal to those of RT for both stage 1 and 2 glottic cancer.

Wait times for head and neck cancer patients in the Maritime provinces.

OBJECTIVE: To assess wait times for surgery and radiotherapy in head and neck cancer patients from the Maritime provinces. METHODS: A retrospective chart review of 275 Maritime head and neck cancer patients treated between 2007 and 2009 by the tertiary Otolaryngology-Head and Neck Surgery Service at the Queen Elizabeth II Health Sciences Centre (QEII HSC) in Halifax, Nova Scotia, was conducted to assess surgical and radiotherapy wait times. RESULTS: The mean wait time from referral to assessment by a head and neck surgeon was 15 days. The mean wait time from the initial consultation with a head and neck surgeon to surgery was 33 days, with 42% waiting more than 28 days and 18% waiting more than 42 days for surgery. The mean wait time from surgery to postoperative radiotherapy was 74 days, with 94% of patients waiting more than 42 days. The mean wait time from referral to Radiation Oncology to assessment by a radiation oncologist was 10 days. The mean wait time from ready to treat to radiotherapy was 21 days, with 74% of patients waiting more than 14 days. CONCLUSION: Maritime head and neck cancer patients wait longer than established guidelines for both surgery and radiotherapy and may be at increased risk for negative outcomes because of delayed treatment.

Effect of fibula free flap harvest on the gait of head and neck cancer patients: preliminary results.

OBJECTIVE: To determine the impact of fibula free flaps (FFFs) on gait. DESIGN: Prospective trial. SETTING: FFF patients who gave consent were enrolled. METHODS: At preoperative and 3-month postoperative visits, patients walked 30 m with the Walkabout Portable Gait Monitor (WPGM), a portable device developed at Dalhousie University that records acceleration of the centre of mass. Gaitview software provided several outputs for analysis: vertical (VA) and forward (FA) asymmetry, horizontal to vertical power ratio (HVP), vertical to forward power ratio (VFP), velocity, and step length. Patients were compared pre- and postoperatively and to age-matched control data with a Student paired t-test. Patients completed a self-comorbidity questionnaire and a point evaluation system (PES) with subjective questions on gait. PES data were compared to a Mann-Whitney U test using SPSS, version 15.0.1. MAIN OUTCOME MEASURES: Gaitview output and PES questionnaire. RESULTS: From September 2008 to January 2010, 12 patients enrolled in the study. Eight provided 3-month postoperative data. The Gaitview analysis showed that none of the six parameters changed postoperatively. The VA and FA preoperatively and at 3 months postoperatively were 21.3 versus 24.2, p > .50, and 65.4 versus 74.9, p > .50, respectively. The HVP and VFP preoperatively and postoperatively were 133.4 versus 138.9, p > .50, and 129.6 versus 122.8, p > .50, respectively. The velocity and step length preoperatively and postoperatively were 125.9 versus 119.5 cm/s, p > .50, and 76.0 versus 74.9 cm, p > .50, respectively. The subjective PES questionnaire did not change significantly (p  =  .26). CONCLUSION: Preliminary findings confirm that the FFF is associated with little subjective or objective gait impairment.

Total nasal reconstruction: use of a radial forearm free flap, titanium mesh, and a paramedian forehead flap.

BACKGROUND: reconstruction of a total nasal defect presents a significant challenge to the reconstructive surgeon. The form, function, and aesthetic appeal of all the nasal subunits must be addressed. Classic teaching emphasizes the importance of restoring the internal lining of the nose, the rigid scaffolding, and the outer skin and soft tissue layer. METHODS: a restrospective review was undertaken in eight patients who had undergone total nasal reconstruction in two Canadian tertiary care centres. All eight patients had their nasal defect reconstructed with a radial forearm free flap for internal lining, titanium mesh for structural support, and a paramedian forehead flap for skin and soft tissue cover. Nasal function, graft survival, patient satisfaction, and complications were recorded. RESULTS: seven of eight patients were satisfied with the cosmetic outcome of their nasal reconstruction. Two patients reported poor nasal breathing owing to nasal stenosis. Two cases of minor titanium extrusion required operative intervention for repair. There were no cases of loss of the radial forearm free flap or paramedian forehead flap in this series. CONCLUSIONS: reconstruction with a radial forearm free flap, titanium mesh, and a paramedian forehead flap is a reliable, cosmetically appealing, and functional method for total nasal reconstruction. Minor surgical revisions should be anticipated to achieve the best cosmetic outcome. This is the first reported series using these three entities together to reconstruct total and subtotal rhinectomy defects.

Is preoperative ultrasonography accurate in measuring tumor thickness and predicting the incidence of cervical metastasis in oral cancer?

The need for elective neck dissection in patients with early stage oral cancer is controversial. A preoperative predictor of the risk of subclinical nodal metastasis would be useful. Studies have shown a strong correlation between histological tumor depth and the risk of nodal metastasis. To determine if preoperative ultrasonography is an accurate measure of tumor depth in oral carcinoma. To assess if preoperatively measured tumor depth predicts an increased risk of subclinical metastatic neck disease and thus the need for elective neck dissection. Twenty one consecutive patients with biopsy proven squamous cell carcinoma of the tongue/floor of mouth were analyzed prospectively. Each patient received a preoperative ultrasonography to assess tumor depth which was compared to histological measures. Univariate analysis was used to correlate tumor thickness and T stage with neck metastasis. There was a significant correlation between the preoperative ultrasonography and histological measures of tumor depth (correlation coefficient 0.981, P<0.001). The overall rate of lymph node metastasis was 52%. The rate of metastasis was 33% in N0 necks. In the group with tumors<5mm in depth, the neck metastatic rate was 0%, as compared with 65% in the group 5mm. Using univariate analysis tumor depth and T stage were significant predictors of cervical metastasis (P=0.0351 and P=0.0300, respectively). Preoperative ultrasonography is an accurate measure of tumor depth in oral carcinoma. Tumor thickness is a significant predictor of nodal metastasis and elective neck dissection should be considered when this thickness is 5mm.

Radiotherapy for T1 and T2 laryngeal cancer: the Dalhousie University experience.

OBJECTIVE: To report outcomes of definitive radiotherapy for early-stage squamous cell carcinoma of the larynx. DESIGN: Retrospective outcome analysis. SETTING: Tertiary referral centre. PATIENTS AND METHODS: A total of 373 cases of laryngeal cancer reported in Nova Scotia from 1990 through 2001 were reviewed. All cases were classified by T stage (T1 = 137, T2 = 90, T3 = 89, T4 = 57) and affected sites (glottic = 233, supraglottic = 136, subglottic = 4). We focused on those patients with T1 and T2 cancers of both the glottis and the supraglottis who received radiotherapy as a primary modality. RESULTS: Eighty-eight percent (150 of 170) of T1/T2 glottic cancers were first treated with radiotherapy. Seventy-one percent (80 of 112) and 63.3% (24 of 38) of T1 and T2 glottic cancers, respectively, were controlled by radiation, with an average follow-up of 37 months. Of those T1 glottic cancers unsuccessfully treated by radiotherapy, 14 underwent surgical salvage, with 9 of these patients being free of disease following an average of 57 months. For T2 glottic cancers unsuccessfully treated by radiotherapy, five patients underwent surgical salvage, of whom four (68.4%) were free of disease after an average follow-up of 62 months. Seventy-five percent of T1 (3 of 4) and 70.6% (25 of 35) of T2 supraglottic cancers were successfully controlled by radiotherapy. Salvage surgery was attempted in five patients; however, all patients except one died of disease. CONCLUSION: Although radiotherapy is a standard treatment for early laryngeal cancers, the results of this review may suggest considering other modalities in the treatment of early laryngeal cancer.