ABSTRACT
An attempt was made to apply the hyperbaric oxygenation (HBO) in victims with craniocerebral trauma. HBO sessions were carried out in a low excess pressure (0.2 ATA) with the simultaneous use of clonidin as antihinoxant and antioxidant (2 mkg/kg), which was done for the purpose of eliminating or decreasing the pronouncement degree of additional stimulation of the lipid-peroxidation processes by hyperbaric oxygen (such processes were already stimulated by combined trauma). Requirements are substantiated on the need in a differential approach to the indication of the HBO course even if it is implemented in the described (sparing) regime. If there is a negative body response to the HBO effect, which happened in 8 of 18 persons according to our observations, the HBO course must be interrupted.
Subject(s)
Craniocerebral Trauma/therapy , Critical Care , Hyperbaric Oxygenation/methods , Clonidine/therapeutic use , Combined Modality Therapy , Craniocerebral Trauma/drug therapy , HumansABSTRACT
In rats with a hemodynamic disorder caused by acute myocardial ischemia, preliminary administration of beditin in a dose of 25 mg/kg fully prevents a manifold increase in the level of 45Ca2+ in the cytosol of brain cells and leads to enhanced trapping and accumulation of labeled calcium in endoplasmic reticulum. With respect to calcium binding in endoplasmic reticulum, the action of beditin substantially differs from that of verapamil.
Subject(s)
Adrenergic alpha-2 Receptor Antagonists , Anticonvulsants/therapeutic use , Brain/metabolism , Calcium Channel Blockers/therapeutic use , Calcium/metabolism , Dioxanes/therapeutic use , Seizures/drug therapy , Thiazoles/therapeutic use , Animals , Endoplasmic Reticulum/metabolism , Mice , Rats , Seizures/etiology , Seizures/metabolism , Species SpecificityABSTRACT
El seminoma primario puro del mediastino es un tumor maligno que supone el 35 por ciento de los tumores malignos mediastinos de células germinales. Se presenta el caso de un paciente masculino de 32 años de edad con enfermedad actual de cuatro meses de evolución caracterízada por dolor torácico, disnea, tos seca, alza térmica y pérdida de peso. Al examen físico presenta depresión acentuada en región esternal y disminución de murmullo vesicular en 2/3 inferiores de hemitórax izquierdo. Radiografía de tórax: imagen dura homogénea, que ocupa 1/3 medio con ensanchamiento mediastínico. TAC de tórax: gran masa mediastínica que compromete espacio prevascular, desplazamiento de estructuras vasculares, mide 11,5 cm x 7,5 cm. RMN de tórax se delimita masa tumoral con desplazamiento de elementos vasculares y cámara cardíaca. Ecosonograma testicular se observan testículos de forma tamaño normal. El estudio inmunohistoquímico reporta seminoma clásico. Recibe tratamiento radiante externo, 2 600 cGy en 3 semanas. Se observó, en controles radiográficos y de RMN, reducción del 45 por ciento de la lesión y, el paciente mejoró clínicamente. Se presenta el caso por tratarse de paciente joven con tumor radiosensible de buen pronóstico motivo por el cual es fundamental el diagnóstico precoz y la instauración de tratamiento radiante temprano
Subject(s)
Humans , Male , Adult , Radiotherapy , Seminoma , Mediastinal Neoplasms , Venezuela , Medical OncologyABSTRACT
Beditine, 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride is a new substance which reduced platelet activation and degranulation, prevented aggregation and superoxide generation by activated human polymorphonuclear leukocytes (PMNL) and inhibited the activation of arachidonate 5-lipoxygenase. Beditine may, therefore, be a useful agent in the treatment of cardiovascular disease.
Subject(s)
Dioxanes/pharmacology , Lipoxygenase Inhibitors , Neutrophils/drug effects , Platelet Aggregation Inhibitors/pharmacology , Thiazoles/pharmacology , Adenosine Triphosphate/metabolism , Aspirin/pharmacology , Calcimycin , Eicosanoids/biosynthesis , Humans , Neutrophils/metabolism , Nifedipine/pharmacology , Superoxides/metabolismABSTRACT
The authors report the clinical case of a patients who underwent four anaesthetic inductions during a period of 3 months. Two were associated with severe acute hypertension making the intended operation impossible at that time. Thorough investigations led to a diagnosis of phaeochromocytoma. Reviewing the protocol of the four anaesthetic inductions, the authors discuss the mechanism of provocation of paroxysmal hypertension which was seen on two occasions.
