ABSTRACT
The estimation of Russian revision reproducibility of the chronic gastritis OLGA system International classification has been spent. The analysis of Russian pathologists-experts work, considered in estimations of an expression level and prevalence of gastric mucosal atrophic changes, as a tumour predictor, for the identification of chronic gastritis stages (0-IV) has been carried out by kappa-statistics. The different levels of experts' consent according to consent criteria calculation have been estimated. The criteria of consent (k) of leading Russian pathologists have been 0.5 (moderate level of the agreement). In the practice of histopathology researchers' classification a consent level has been lower--from 0.27 (satisfactory or tolerable consent level) to 0.42 (moderate or average consent level). A subjective reasons reducing consistency level of pathologists-experts have been discussed.
Subject(s)
Gastritis/classification , Gastritis/pathology , Chronic Disease , Female , Humans , Male , RussiaABSTRACT
Atrophic antral gastritis was found to show an absolute decrease in gland volume with higher expression of the gastric transcription factor Shh, i.e. absolute atrophy and that concurrent with the replacement of the specialized gastric epithelium by the intestinal MUC2-producing one, i.e. metaplastic atrophy. In atrophic multifocal gastritis along absolute and metaplastic atrophy, there are foci of the proliferative metaplastic epithelium, i.e. hyperproliferative metaplastic atrophy that is prevalent in atrophic pangastritis. The molecular characteristics of hyperproliferative metaplastic atrophy are varying: in some foci of metaplasia, the high proliferative activity of the epithelium is concomitant with the hyperexpression of P53, a marker of DNA damage, the lower expression of the intestinal transcription factor CDX-2, and the low level of Cpp32, an indicator of apoptosis. Whether such structures can be identified at the launching pad for tumor growth in atrophic pangastritis is discussed.
