Erythropoietin induces biphasic activation of p70S6k: evidence for a different regulation of early and late phase of activation.

The murine erythroleukaemia cell line HCD-57 proliferates in response to erythropoietin. Stimulation of erythropoietin-deprived cells with the cytokine induces the phosphorylation and biphasic activation of the 70,000 M(r) S6 kinase. Two peaks of enzyme activity were observed after 30 and 120 min, respectively. Early and late phase of activation differ in their sensitivity to the protein kinase C inhibitor staurosporine suggesting different regulatory mechanisms.

Massive scrotal herniation of bladder with torsion of trigone.

We report on a patient with massive scrotal herniation of the bladder, scrotal cystocele, including and causing partial torsion of the trigone. The incidence and etiology of scrotal herniation are discussed.