Combined positron emission tomography and contrast enhanced CT (PET/CeCT) is a feasible single investigation in the staging of oesophagogastric cancers: single-centre pilot study experience during the COVID-19 pandemic.

INTRODUCTION: Staging of oesophagogastric (OG) cancers usually involves endoscopy (OGD), and separate visits for contrast enhanced computed tomography (CeCT) and positron emission tomography (PET/CT). At the height of the COVID-19 pandemic, some of our patients underwent single-visit combined staging with PET/CeCT. We compare this novel pathway with standard separate imaging in time to completion of staging, to start of treatment, and cost. METHODS: We identified all patients discussed at our OG multidisciplinary team (MDT) meeting in 2020. Clinical records revealed dates of investigations and treatments. Data were tabulated in Excel, with statistical analysis in SPSS. All patients followed the same MDT process and image reviewing criteria. Costs were compared using prices supplied by finance departments. RESULTS: A total of 211 new patients were discussed at our MDT in 2020. Of these, 48 patients had combined PET/CeCT staging, and 68 had separate scans. Median time (interquartile range) in days from OGD to final imaging was 9 (6-23) for the combined group versus 21 (16-28) for the separate group (p≤0.001). Median time (days) from OGD to treatment start was 37 (29-52) for combined versus 55 (40-71) for separate (p≤0.001). No combined scans were of insufficient diagnostic quality for the MDT. PET/CeCT had a potential cost saving of £113 per patient. CONCLUSIONS: PET/CeCT allows accurate radiological staging of OG cancers with a single scan. Patients completed staging and started treatment faster, with a potential saving of £10,509 in one year. PET/CeCT has become standard staging at our trust, and we aim to incorporate radiotherapy planning images too.

Multivariate semiparametric control charts for mixed-type data.

A useful tool that has gained popularity in the Quality Control area is the control chart which monitors a process over time, identifies potential changes, understands variations, and eventually improves the quality and performance of the process. This article introduces a new class of multivariate semiparametric control charts for monitoring multivariate mixed-type data, which comprise both continuous and discrete random variables (rvs). Our methodology leverages ideas from clustering and Statistical Process Control to develop control charts for MIxed-type data. We propose four control chart schemes based on modified versions of the KAy-means for MIxed LArge KAMILA data clustering algorithm, where we assume that the two existing clusters represent the reference and the test sample. The charts are semiparametric, the continuous rvs follow a distribution that belongs in the class of elliptical distributions. Categorical scale rvs follow a multinomial distribution. We present the algorithmic procedures and study the characteristics of the new control charts. The performance of the proposed schemes is evaluated on the basis of the False Alarm Rate and in-control Average Run Length. Finally, we demonstrate the effectiveness and applicability of our proposed methods utilizing real-world data.

Generalizations of Runs and Patterns Distributions for Sequences of Binary Trials.

In the present paper we study the distributions of families of patterns which generalize runs and patterns distributions extensively examined in the literature during the last decades. In our analysis we assume that the sequence of outcomes under investigation includes independent, but not necessarily identically distributed trials. An illustration is also provided how our new results could be exploited to enrich a new system, still in research, related to patients' weaning from mechanical ventilation.

Clinical relevance of circulating CK-19 mRNA-positive cells detected during the adjuvant tamoxifen treatment in patients with early breast cancer.

BACKGROUND: The purpose of this study was to evaluate the effect of adjuvant treatment with tamoxifen on the CK-19 mRNA+ cells in patients with early-stage breast cancer. PATIENTS AND METHODS: CK-19 mRNA+ cells were prospectively and longitudinally detected using a specific real-time PCR assay for CK-19 mRNA in 119 patients with estrogen and/or progesterone receptor-positive tumors during the period of tamoxifen administration. RESULTS: Twenty-two (18.5%) patients had detectable CK-19 mRNA+ cells after the completion of adjuvant chemotherapy and in 15 (68.2%) of them adjuvant tamoxifen could not eliminate these cells (persistently positive). In 68 (57.1%) patients, no CK-19 mRNA+ cells could be detected throughout the follow-up period (persistently negative). Seven (46.7%) of the 15 persistently positive and six (8.8%) of the 68 persistently negative patients developed disease recurrence (P = 0.00026). Persistency of CK-19 mRNA+ cells was associated with a significantly lower median disease-free interval (P = 0.0001) and overall survival (P = 0.0005). Multivariate analysis revealed that the detection of CK-19 mRNA+ cells during the administration of tamoxifen was associated with an increased risk of relapse [hazard ratio (HR) = 22.318, P = 0.00006] and death (HR = 13.954, P < 0.00001). CONCLUSIONS: The detection of CK-19 mRNA+ cells throughout the period of adjuvant tamoxifen treatment is an independent poor prognostic factor in patients with early breast cancer.

CT herniography in the diagnosis of occult groin hernias.

AIM: To evaluate the role of computed tomography (CT) after herniography in the diagnosis and management of primary and recurrent groin hernias not detectable on clinical examination. MATERIAL AND METHODS: Fifty-one patients underwent CT post-herniography over a 6-year period for suspected primary or recurrent inguinal hernia. The herniography and post-herniography CT findings were retrospectively compared with clinical and surgical follow-up. Statistical analysis was performed to assess the role of herniography and CT post-herniography in the primary and recurrent groups. RESULTS: Of the 51 patients investigated for occult inguinal hernia, 19 had previous hernia repair with possible recurrence. The most common symptom at presentation was groin pain or discomfort (84%). Seventy-five percent in the primary group and 84% in the recurrent group had no findings on herniography or CT. Nine percent in the primary group and 16% in the recurrent group had hernias diagnosed by herniography. CT did not enhance the detection of hernia. Sensitivity for herniography and CT herniography in the primary groin hernia group was 75% as against specificity, which was 100 and 90%, respectively. For the recurrent groin hernias, sensitivity was 60% for herniography and 40% for CT herniography and specificity 100% for both. CONCLUSION: CT performed post-herniography did not provide any benefit over performing herniography alone in the diagnosis of occult primary or recurrent inguinal hernias.

A New Perspective On Sequential Testing Procedures In Canonical Analysis: A Monte Carlo Evaluation.

A Monte Carlo study was conducted in order to compare four testing procedures in establishing the number of nonzero population roots in a canonical analysis. Three of the methods investigated were sequential testing methods which have lately fallen under heavy criticism. The fourth method was a test advocated by Harris (1976) to be a more appropriate test. Results demonstrated the effectiveness of the sequential testing procedures and the relative ineffectiveness of the Harris method. The conclusion was that the criticisms aimed at the sequential testing for nonzero roots in canonical analysis are simply not well-founded.