Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk.

Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%-70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.

Defectos de crecimiento fetal tardío: manejo prenatal y resultados perinatales en el ámbito de un hospital de nivel II / Late fetal growth defects: prenatal management and perinatal outcomes in a level II hospital setting

Objetivo: comparar el manejo prenatal y los resultados perinatales entre fetos pequeños para la edad gestacional y con crecimiento intrauterino restringido. Sujetos y métodos: estudio retrospectivo observacional de gestantes con fetos con peso estimado inferior al percentil 10 entre 2010 y 2013. Revisamos 5.162 partos; 139 cumplieron criterios de inclusión (48 pequeños para la edad gestacional y 91 crecimiento intrauterino restringido). Resultados: el análisis estadístico comparando ambos grupos mostró diferencias significativas (p <0,05) en: semanas en el momento del parto (39,6 en pequeños para la edad gestacional vs. 38,4 en crecimiento intrauterino restringido), prematuridad (0% vs. 14,3%), peso neonatal (2.595 g vs. 2.368 g), inducciones (41,7% vs. 81,3%), registros cardiotocográficos intraparto patológicos (14,5% vs. 36,2%) y tasa de cesáreas por pérdida del bienestar fetal (12,5% vs. 36,2%). Conclusiones: los hallazgos confirman la existencia de diferencias entre ambos grupos. A pesar de que los fetos con crecimiento intrauterino restringido presentan más riesgo de resultados perinatales adversos, la estrecha monitorización antenatal y durante el parto permite obtener resultados comparables a los fetos pequeños para la edad gestacional (AU)

Objective: To compare perinatal outcomes between fetuses small-for-gestational-age and those with intrauterine growth restriction. Subjects and methods: This is a retrospective observational study of pregnancies between 2010 and 2013 with an estimated fetal weight below 10th centile diagnosed by ultrasonography. We reviewed 5,162 deliveries and 139 were included in the study (48 were small-for-gestational-age and 91 were intrauterine growth restriction). Results: Statistical analysis comparing both groups showed significant differences (p <0,05) in: gestational age at delivery (39.6 in small-for-gestational-age vs. 38.4 in intrauterine growth restriction), prematurity (0% vs. 14.3%), newborn weight (2,595 g vs. 2,368 g), induction of labour (41.7% vs. 81.3%), non-reassuring features on cardiotocograph (14.5% vs. 36.2%) and caesarean section rate for non-reassuring fetal status (12.5% vs. 36.2%). Conclusion: Our findings confirm the suspicion of differences between both groups. Although fetuses with intrauterine growth restriction are at higher risk of poor outcome when compared to small-for-gestational-age, close monitoring antenatally and during labour allows to obtain outcomes similar to those fetuses small-for-ges-tational-age (AU)