Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction: a randomized, double-blind clinical trial

Background: To evaluate the efficacy of intra-alveolar administration of dexamethasone 4 mg in the control of edema, trismus, and pain resulting from the extraction of impacted lower third molars and the drug permeability through the oral mucosa by in silico prediction. Material and Methods: The randomized, double-blind, split-mouth clinical trial included patients who had both impacted lower third molars in equivalent positions. Hemiarches were divided into control side when dexamethasone was administered orally and experimental side when dexamethasone was administered using the intra-alveolar route. Patients were evaluated considering edema, trismus, and pain. The permeability of dexamethasone through the oral mucosa was assessed by in silico prediction. Student’s t-test was selected for comparative analysis of edema and trismus, and the chi-square test analyzed the distribution of postoperative pain between the sides. Results: There were no significant differences between the routes of administration in measuring symptoms between the pre and postoperative times (p>0.05). In silico prediction suggested that dexamethasone molecular characteristics facilitate intra-alveolar administration. Conclusions: Intra-alveolar administration had similar efficacy to oral administration in controlling symptoms of post-surgical inflammation of impacted lower third molars.(AU)

Histopathological evaluation of dental follicles associated with impacted third molars

Aim: To histologically evaluate dental follicles of impacted third molars with no radiographic evidence of pathology. Methods: We carried out both a quantitative and qualitative analysis of pericoronal follicles removed from impacted third molars and investigated the association with clinical data. The sample included 36 extracted dental follicles of impacted third molars, obtained from 28 patients, which presented with no radiographic evidence of pathologies. Results: None of the follicles analyzed showed any pathological entity. The epithelial lining was observed in 61.1% of samples, being identified as reduced enamel epithelium. We found a significant relation between the the presence of inflammatory infiltrate and the group aged over 21 years (64.3%; p<0.05). Conclusions: Considering the absence of pathological lesions, we suggest that impacted third molars should only be extracted in young-aged individuals due to specific pathologies or indications

Efeito de agentes dessensibilizantes na resistência de união de um sistema adesivo autocondicionante / Effect of desensitizing agents on shear bond strength of a self-etching adhesive

Uma adesão satisfatória pode ser dificultada na presença de agentes dessensibilizantes, como nas cavidades do tipo Classe V. Este estudo teve como objetivo investigar a influência de dois agentes dessensibilizantes na resistência de união de um sistema adesivo autocondicionante quando aplicados previamente ao sistema adesivo. Foram utilizadas 30 coroas de incisivos bovinos, sendo incluídos em buchas de redução de PVC pré-fabricadas, com auxílio de resina acrílica. A superfície vestibular foi preparada, deixando a dentina exposta e os 30 conjuntos foram divididos em três grupos: G1 (adesivo + resina), G2 (oxagel + adesivo + resina) e G3 (G.H.F + adesivo + resina). Então, cilindros de resina composta (4 mm de diâmetro e 4 mm de altura) foram confeccionados. Decorridas 24 horas, os espécimes foram submetidos ao ensaio de cisalhamento e velocidade do atuador de 0,5 mm/min. Os dados foram submetidos ao teste de análise de variância de um fator (Anova - one way), complementados pelo teste de Tukey. Houve diferença estatística significante entre os tratamentos (G2 - 2,49 < G1 - 11,01 = G3 - 10,1). Assim, conclui-se que a resistência de união do sistema adesivo autocondicionante na dentina pré-tratada com agentes dessensibilizantes é prejudicada pelo uso do produto à base de oxalato.

A satisfactory bonding may be hampered in the presence of desensitizers agents, such as class V cavities. The aim of this study was to compare the effect of two different desensitizers on shear bond strength of a self-etch adhesive system. Thirty crowns of bovine incisors were mounted in pre-fabricated acrylic PVC using acrylic resin. The vestibular surface was prepared exposing the dentin and the crowns were divided into three groups: G1 (adhesive + resin), G2 (oxagel + adhesive + resin), and G3 (GHF + adhesive + resin). Resin composite cylinders (4 mm in diameter and 4 mm in height) were then placed. After 24 hours, shear bond strengths were measured using a circular knife-edge and crosshead speeds of 0.5 mm/minute. One-way ANOVA and Tukey’s tests were used to compare the different conditions for bonding system. There was a statistically significant difference between treatments (G2 – 2.49 < G1 – 11.01 = G3 – 10.1). It was concluded that the shear bond strength of the self-etch adhesive system on dentin pre-treated with desensitizing agents is decreased by the use of the product based on oxalate