ABSTRACT
Ewing's sarcoma is an aggressive tumour, common in paediatric age, in which treatment often implies a decrease in reproductive potential. We describe a case of a woman who had a lumbar Ewing's Sarcoma in 1991, at the age of 8. She was submitted to extended tumourectomy, chemotherapy and local radiotherapy without preservation techniques. In adult life, and after two in vitro fertilization (IVF) reproductive cycles without success, she spontaneously conceived at the age of 32. After an uneventful pregnancy, she delivered a healthy child by caesarean section. This is a rare successful case of a spontaneous and uneventful pregnancy without previous preservation techniques. In the last 30 years, there has been significant development in this area, and currently, there are solutions for these patients, including in prepubertal age.
Subject(s)
Bone Neoplasms , Neuroectodermal Tumors, Primitive, Peripheral , Sarcoma, Ewing , Adult , Cesarean Section , Child , Female , Fertilization , Humans , Pregnancy , Sarcoma, Ewing/therapyABSTRACT
A 11-month-old, intact male, Rhodesian Ridgeback was presented to the Veterinary Teaching Hospital with signs of inappetence, lethargy, and abdominal pain for 3 days. A large and well-defined abdominal retroperitoneal mass, related with the left kidney, at the expected location of the adrenal gland, was revealed by radiography, ultrasound, and computed tomography. The mass extended caudally to the iliac artery bifurcation, compressing the aorta, caudal vena cava, and both kidneys. Cytology findings were compatible with a malignant round cell tumor. The most probable diagnosis was neuroblastoma. Following a comprehensive discussion with the owners about a treatment plan, surgical excision was performed. Because a wide excision would compromise major vessels, excision was performed after careful dissection of the aorta and vena cava. The left kidney was removed because the proximal ureter could not be separated from the tumor. The animal recovered successfully. Diagnosis was confirmed by histopathology and immunohistochemistry, but the owners decided not to pursue any further treatment. Clinical signs of abdominal pain recurred within 1 month following surgery. Therefore, the animal was euthanized upon the owners' request. This report describes the diagnosis, surgical treatment, and follow-up of a dog with an abdominal peripheral neuroblastoma.
ABSTRACT
Myosin heavy chain 9-related disorders (MYH9RD) are a genetic condition characterised by large platelets and thrombocytopaenia. The May-Hegglin anomaly (MHA), an uncommon condition with a potential risk of bleeding complications once thought to be separate, is now known to be part of MYH9RD.There are very limited data on the clinical course and neonatal/paediatric outcome in children with MHA. We present the case of a newborn with a normal physical examination whose mother had MHA. Peripheral blood examination revealed a platelet count of 16×109/L with giant platelets and neutrophils containing Döhle bodies. Neonatal brain ultrasound examination showed no haemorrhage. The infant received three platelet transfusions during the first 29 days of life, remaining asymptomatic. The genetic molecular test was positive for MYH9RD. It is important to identify at-risk infants with this condition and to initiate therapy to prevent related complications, if needed, in a multidisciplinary team approach.
Subject(s)
Hearing Loss, Sensorineural/diagnosis , Molecular Motor Proteins/genetics , Myosin Heavy Chains/genetics , Platelet Transfusion , Thrombocytopenia, Neonatal Alloimmune/genetics , Thrombocytopenia/congenital , Blood Platelets , Female , Genetic Testing , Hearing Loss, Sensorineural/therapy , Humans , Infant, Newborn , Infant, Small for Gestational Age , Pedigree , Platelet Count , Thrombocytopenia/diagnosis , Thrombocytopenia/therapy , Thrombocytopenia, Neonatal Alloimmune/therapyABSTRACT
Heterotopic salivary gland tissue consists of otherwise normal salivary tissue, but occurs at a site in which it is normally not present (outside of the major, minor, and accessory salivary glands), with absence of clinical and histological features of branchial cleft anomalies. We herein present a 7-year-old boy with drainage from a small, congenital cystic lesion located at the base of the neck, which was histologically confirmed as salivary gland tissue.
Subject(s)
Choristoma/pathology , Salivary Glands , Skin Diseases/pathology , Child , Choristoma/congenital , Choristoma/surgery , Humans , Male , Neck , Skin Diseases/congenital , Skin Diseases/surgeryABSTRACT
The authors describe a case of congenital ranula diagnosed by a routine prenatal ultrasonography at 21 weeks of gestation. The fetal kariotype was normal. Follow-up ultrasound scans revealed no changes in the size or the position of the cyst. Fetal growth was normal as was the amniotic fluid volume. Surgical treatment was performed 3 days after a normal vaginal delivery, with excellent results.
Subject(s)
Ranula/congenital , Ranula/diagnostic imaging , Ultrasonography, Prenatal , Adult , Female , Humans , Infant, NewbornABSTRACT
A alimentacao das criancas portadoras de fissura congenita labio-palatal nao pode ser esquecida ou relegada a plano secundario pois, trata-se de uma das queixas mais frequentes durante as consultas pediatricas. Os autores comentam as experiencias adquiridas na pratica da alimentacao destas criancas no Hospital de Pesquisa e Reabilitacao de Lesoes Labio-Palatais (HPRLLP), alem da conduta neonatal e as orientacoes aos pais e familiares .
