A new biologic prosthesis for vascular substitute in mongrel dogs.

New glutaraldehyde-treated vascular prosthesis tubes of bovine pericardium were placed in the abdominal aortas of 29 mongrel dogs and observed for 30 to 540 days. Clinical evaluation was performed during follow-up, and histologic and arteriographic studies were done at the end of the study. Patency was shown by arteriography in 27 of 29 tubes (93.1%). Neoendothelialization was found in all grafts, and there was a mixed effect, characterized by both rejection and foreign body reaction in the prostheses from 180 days onward. Both the handling and consistency of the grafts were excellent for implantation. Graft procoagulation and animal anticoagulation were not necessary.

Uso de un antitrombotico a largo plazo en pacientes con insuficiencia arterial de miembros inferiores. / A long term use of an antithrombotic agent in patients with arterial insufficiency

Se exponen las experiencias de mas de 10 anos con el empleo de un antitrombotico, dipiridamol, administrado a largo plazo (promedio 72 meses), en pacientes sujetos a cirugia por arteriopatia oclusiva arteriosclerotica o tromboembolica. Un grupo testigo, sin medicacion antitrombotica, sirve de control. El grupo A muestra una incidencia muy baja de fenomenos tromboembolicos, durante los periodos en que se administra el dipiridamol y alta incidencia cuando se suspende este medicamento.El grupo B, sin medicacion antitrombolica, presenta el segundo episodio oclusivo en mas del 50% de los pacientes